Abstract: RNA molecules for RNA interference to target a mutant allele with a point mutation, wherein the molecule has a nucleotide sequence complementary to a nucleotide sequence of a coding region of the mutant allele; and when counted from the base at the 5?-end in the nucleotide sequence complementary to the sequence of the mutant allele: a base at position 5 or 6 is mismatched with a base in the mutant allele; a base at position 10 or 11 is at the position of the point mutation and is identical to the base at the position of the point mutation in the mutant allele; the group at the 2?-position of the pentose in the ribonucleotide at position 8 is modified with OCH3, halogen, or LNA; and the group at the 2?-position of the pentose in the ribonucleotide at position 7 is not modified with any of OCH3, halogen, and LNA.

Abstract: An image processing method includes acquiring a captured image obtained by image capturing using an optical system, acquiring correction strength for a sharpening process applied to a partial area in the captured image, and applying the sharpening process to the partial area based on a first optical characteristic and the correction strength, wherein the correction strength is acquired based on a second optical characteristic, wherein the first optical characteristic is an optical characteristic of the optical system in a case where the optical system is defocused by a first defocus amount, wherein the second optical characteristic is an optical characteristic of the optical system in a case where the optical system is defocused by a second defocus amount, and wherein the second defocus amount is smaller than the first defocus amount.

Abstract: A robot capable of performing precise work is provided. The robot includes an actuator unit and an end effector provided at a tip of the actuator unit. The end effector includes a first sensor capable of detecting a pressure distribution in a contact region coming into contact with a workpiece, and a second sensor capable of detecting position information of the contact region.

Abstract: Provided is a driving evaluation device that enables evaluation of driving for the purpose of improving a driving time in a circuit racecourse. The driving evaluation device includes an evaluation section extractor 24 that detects a deceleration section and an acceleration section in cornering, a tire friction circle-load factor calculator 27 that calculates, based on a front-rear acceleration and a lateral acceleration, a tire friction circle and a tire load factor in the deceleration section and those in the acceleration section, and a skill deficiency evaluator 28 that evaluates driving based on the tire friction circle and the tire load factor in the deceleration section and those in the acceleration section.

Abstract: Provided is an information processing device which is capable of suppressing a deterioration in accuracy of detecting an anomaly and accuracy of analyzing the anomaly, while suppressing an increase in an amount of data to be stored. The information processing system includes anomaly detection unit that collects event data indicating a predetermined event detected in a process of a device to be monitored, determines whether a predetermined index value related to the event exceeds a preset first threshold, and instructs enhanced monitoring of the device to be monitored and the process related to the event when the index value exceeds the first threshold, and collection instruction unit that determines an additional event being an event to be additionally monitored when the enhanced monitoring is instructed, and instructs the device to be monitored, which is subjected to the enhanced monitoring, to monitor the determined additional event.

Abstract: An information presentation system includes a controller that controls a device included in a production line, a terminal including a display and a camera that captures an image of the device, and a server that communicates with the controller and the terminal. The camera has an image capture range including a view field of the display. The controller transmits a light emission command to the device, the light emission command causing a light emitter included in the device to emit light in a predetermined light emission pattern. The terminal displays information regarding the device in association with a display position in a display area of the display, the display position corresponding to a position of a partial image representing the light emission pattern in a captured image of the camera.

Abstract: A network system for an electronic conference in which users interact by transmitting and receiving data by computers connected to a network is provided. The computers include one or more terminal devices, a control device that controls a target, and a server device that receives data and that distributes the received data to a device different from a transmission source of the data. The control device includes a module that executes a control arithmetic operation, and a detection module that detects an event indicating a matter generated in association with the target from an operation state of the target according to control. The network system includes a module that transmits a convocation notice to an electronic conference in order to correspond to the event to one or more users to be involved in correspondence of the event through the network when detecting the event by the detection module.

Abstract: RNA molecules for RNA interference to target a mutant allele with a point mutation, wherein the molecule has a nucleotide sequence complementary to a nucleotide sequence of a coding region of the mutant allele; and when counted from the base at the 5?-end in the nucleotide sequence complementary to the sequence of the mutant allele: a base at position 5 or 6 is mismatched with a base in the mutant allele; a base at position 10 or 11 is at the position of the point mutation and is identical to the base at the position of the point mutation in the mutant allele; the group at the 2?-position of the pentose in the ribonucleotide at position 8 is modified with OCH3, halogen, or LNA; and the group at the 2?-position of the pentose in the ribonucleotide at position 7 is not modified with any of OCH3, halogen, and LNA.

Abstract: The present invention is directed to provide novel RNA molecules, chimeric NA molecules, double-stranded RNA molecules, and double-stranded chimeric NA molecules. Specifically, an embodiment of the present invention is an RNA molecule for RNA interference to target a mutant allele with a point mutation, in which (1) the molecule has a nucleotide sequence complementary to a nucleotide sequence of a coding region of the mutant allele; and (2) when counted from the base at the 5?-end in a nucleotide sequence complementary to a nucleotide sequence of the mutant allele, (2-1) a base at position 5 or 6 is mismatched to a base in the mutant allele; (2-2) a position 10 or 11 corresponds to the position of the point mutation; and (2-3) a group at the 2?-position of a pentose at positions 6-8 or positions 7 and 8 is modified with, e.g., OCH3. In this RNA molecule, one or more ribonucleotides may be replaced by, e.g., a deoxyribonucleotide. The molecule may form a double-stranded RNA with a complementary strand.

Abstract: Provided is a driving evaluation device that enables evaluation of driving for the purpose of improving a driving time in a circuit racecourse. The driving evaluation device includes an evaluation section extractor 24 that detects a deceleration section and an acceleration section in cornering, a tire friction circle-load factor calculator 27 that calculates, based on a front-rear acceleration and a lateral acceleration, a tire friction circle and a tire load factor in the deceleration section and those in the acceleration section, and a skill deficiency evaluator 28 that evaluates driving based on the tire friction circle and the tire load factor in the deceleration section and those in the acceleration section.

Abstract: A driving assistance apparatus according to the present disclosure includes: a vehicle acceleration detection unit configured to detect vehicle acceleration including lateral acceleration and longitudinal acceleration of a vehicle; a calculation unit configured to calculate for each wheel a friction circle, and a lateral force generated at each wheel and a longitudinal force generated at each wheel on the basis of a result of detection by the vehicle acceleration detection unit; and a display unit configured to display an image based on the friction circle, and a magnitude and/or a direction of a resultant force of the lateral force and the longitudinal force generated at each wheel based on a result of calculation by the calculation unit.

Abstract: Provided is a driving evaluation device that enables evaluation of driving for the purpose of improving a driving time in a circuit racecourse, for example. The driving evaluation device includes an evaluation section extractor 24 that detects a deceleration section and an acceleration section in cornering, a section average classifier 25 that calculates, based on a front-rear acceleration and a lateral acceleration, an acceleration norm average value in the deceleration section and that in the acceleration section, and a skill deficiency evaluator 28 that evaluates driving skill based on the acceleration norm average value in the deceleration section and that in the acceleration section.

Abstract: Provided are a friction stir welding apparatus and a friction stir welding method capable of highly accurate position control in a Z-axis direction (vertical direction) of a joining tool when a joint target member is subjected to friction stir welding by the friction stir welding apparatus.

Abstract: An objective of the present invention is to simplify generation of a program for carrying out data collection performed by a PLC and reduce the burden on an operator. The invention comprises: a device information library (111) which stores program templates corresponding to various process relating to data collection and, for each target device from which data is to be collected, device parameters corresponding to said target device; and a program generation unit (117) which generates a data collection program using program templates and device parameters corresponding to an accepted target device.

Abstract: Provided are a friction stir welding apparatus and a friction stir welding method capable of highly accurate position control in a Z-axis direction (vertical direction) of a joining tool when a joint target member is subjected to friction stir welding by the friction stir welding apparatus.

Abstract: The surface-treated material (10) according to the present invention is a surface-treated material including an electroconductive substrate (1) and a surface treatment coating film (2) including at least one metal layer formed above the electroconductive substrate (1), wherein a lowermost metal layer (21), as a metal layer included in the at least one metal layer and formed above the electroconductive substrate (1), is made of nickel, nickel alloy, cobalt, cobalt alloy, copper, or copper alloy, the surface-treated material includes an intervening layer (3) between the electroconductive substrate (1) and the surface treatment coating film (2), the intervening layer (3) containing a metal component of the electroconductive substrate (1), a metal component of the surface treatment coating film (2), and an oxygen component, and the mean thickness of the intervening layer (3) is in the range of 1.00 nm or larger and 40 nm or smaller as measured in the vertical cross-section of the surface-treated material.

Abstract: An electrical contact material (10) having: a conductive substrate (1) formed from copper or a copper alloy; a first intermediate layer (2) provided on the conductive substrate (1); a second intermediate layer (3) provided on the first intermediate layer (2); and an outermost layer (4) formed from tin or a tin alloy and provided on the second intermediate layer (3), wherein the first intermediate layer (2) is constructed as one layer of grains extending from the conductive substrate (1) side to the second intermediate layer (3) side, and wherein, in the first intermediate layer (2), the density of grain boundaries (5b) extending in a direction in which the angle formed by the grain boundary in interest and the interface between the conductive substrate and the first intermediate layer is 45° or greater, is 4 ?m/?m2 or less; a method of producing the same; and a terminal.

Abstract: Provided is a management system associated with a manufacturing line including one or more facilities. Each of the facilities is configured to process each workpiece according to order information. The management system includes: a collecting means for collecting event information about a process that takes place in each of the facilities; a classifying means for classifying, on the basis of a generation source and content of each piece of event information, the event information collected by the collecting means, into sets of event information generated due to the same workpiece; a generation means for generating data which represents process circumstances for each workpiece on the basis of the event information belonging to each of the sets classified by the classifying means; and a visualizing means for visualizing process progression circumstances for each workpiece processed according to the order information, on the basis of the data generated by the generating means.

Abstract: The present invention provides: a surface-treated material that can simply and in a short time period form a surface treatment film having an adequate adhesiveness particularly on an electroconductive substrate which is mainly formed of a base metal having a large ionization tendency and is considered to resist having a sound plating film formed thereon; and a component produced by using the same.

Abstract: A surface-treated material (10) according to the present invention comprises an electroconductive substrate (1) and a surface treatment film (2) formed of at least one or more layers of metal layers (3 and 4) which are formed on the electroconductive substrate (1), wherein among the at least one or more layers of metal layers (3 and 4), the lowermost metal layer (3) which is directly formed on the electroconductive substrate (1) comprises a plurality of metal-buried portions (3a) that are scattered in the electroconductive substrate (1), branch from a surface of the electroconductive substrate (1) and widely extend toward the inside thereof, and as a vertical cross section of the surface-treated material (10) is viewed, in which at least one of the metal-buried portions (3a) exists in the electroconductive substrate (1), an average value of an area ratio of the metal-buried portion (3a) occupying the predetermined observation region of the electroconductive substrate (1) is in a range of 5% or more and 50% or