Abstract: The separation material for separating and recovering a blood coagulation factor comprises a porous matrix having linked thereon one or more ligands each consisting of a radical exhibiting an affinity for the blood coagulation factor to be recovered, said matrix having a specific surface area of at least 1.5 m.sup.2 per milliliter of the separation material with respect to pores having diameters of at least 0.1 .mu.m and being derived from a porous particulate material having an exclusion limit molecular weight of at least 1.5.times.1.sup.6 as determined with polyethylene glycol. The separation material is prepared by the process steps of subjecting a porous particulate material having an exclusion limit molecular weight of at least 1.5.times.10.sup.

Abstract: A novel ion exchanger useful for universal ion-exchange purposes and, in particular, for ion exchanger for ion-exchange chromatography is proposed, said novel ion exchanger being obtained by introducing radicals of one or more ion-exchangeable groups into cross-linked glucomannan beads by a chemical treatment thereof. Such ion exchanger beads are superior in the compressive strength and permit a high flow rate of the liquid to be subjected to ion exchange through an exchange column packed with them.

Abstract: The present invention provides novel spherical grains of polyamino acid wh can be used as a filler in chromatography, cosmetic powder and the like. The spherical grains can be produced by a method which comprises the steps of preparing a solution of hydrophobic polyamino acid such as poly n-leucine dissolved in an organic solvent; adding the solution to an aqueous medium and agitating said medium so as to obtain a dispersion of the spherical grains of the polyamino acid dispersed in the aqueous medium while evaporating the organic solvent; and taking out the spherical grains of polyamino acid from the dispersion.

Abstract: Beads product of Glucomannan having a cross-linked structure and exhibiting a degree of swelling of in the range from 1.5 to 15, an exclusion limit molecular weight in the range from 200 to 100,000,000 and an average bead diameter in the range from 1 to 500 .mu.m. The glucomannan beads are useful for packing material for gel filtration and for gel chromatography. They can be produced by a process which comprises preparing a starting process solution by dissolving an esterified glucomannan solely or together with a diluent in a solvent, introducing this starting process solution into an aqueous medium so as to cause formation of liquid droplets of the starting process solution suspended in said aqueous medium, evaporating off the solvent contained in the liquid droplets to leave spherical beads of the glucomannan ester, saponifying the so formed beads of glucomannan ester to convert into beads of glucomannan and effecting then cross linking of the saponified beads by reacting with a cross linking solvent.

Abstract: The present invention provides novel spherical grains of polyamino acid wh can be used as a filler in chromatography, cosmetic powder and the like. The spherical grains can be produced by a method which comprises the steps of preparing a solution of hydrophobic polyamino acid such as poly n-leucine dissolved in an organic solvent; adding the solution to an aqueous medium and agitating said medium so as to obtain a dispersion of the spherical grains of the polyamino acid dispersed in the aqueous medium while evaporating the organic solvent; and taking out the spherical grains of polyamino acid from the dispersion.

Abstract: A solution of cellulose triacetate in a mixed solvent consisting essentially of a chlorinated hydrocarbon with a boiling point lower than that of an aqueous medium and an aliphatic higher alcohol with 6 or more than 6 carbon atoms is suspended into the aqueous medium to form droplets of the above-mentioned solution, and then the chlorinated hydrocarbon in the droplets is removed by evaporation to obtain spherical particles of cellulose triacetate containing the aliphatic higher alcohol. The spherical particles thus obtained are saponified and removed of the aliphatic higher alcohol, to prepare porous cellulose spherical particles.