Abstract: The present invention provides a Fentanyl-containing percutaneously absorbable adhesive preparation, which is obtained from economic starting materials, has a constitution simpler than that of conventional ones, has sufficient skin permeability, and which permits control of skin permeability by changing the mixing ratio of two kinds of polyisobutylene having different molecular weights, a tackifier and an organic liquid. Specifically, the present invention provides a percutaneously absorbable adhesive preparation comprising a support and an adhesive layer laminated on one surface thereof, wherein the adhesive layer comprises Fentanyl, two kinds of polyisobutylene having different molecular weights, a tackifier and an organic liquid compatible with the aforementioned two kinds of polyisobutylene and the aforementioned tackifier.

Abstract: The present invention provides an adhesive capable of affording an adhesive layer showing reduced stickiness, reduced cohesive failure and the like. An adhesive containing a copolymer obtained by copolymerizing monomers containing a (meth)acrylic acid alkyl ester as a main component, and a vinyl monomer having a hydroxyl group and/or a carboxyl group and which has an average molecular radius of not less than 70 nm as measured by a multi angle laser light scattering method.

Abstract: The present invention provides an adhesive capable of affording an adhesive layer showing reduced stickiness, reduced cohesive failure and the like. An adhesive containing a copolymer obtained by copolymerizing monomers containing a (meth)acrylic acid alkyl ester as a main component, and a vinyl monomer having a hydroxyl group and/or a carboxyl group and which has an average molecular radius of not less than 70 nm as measured by a multi angle laser light scattering method.

Abstract: The present invention provides a Fentanyl-containing percutaneously absorbable adhesive preparation, which is obtained from economic starting materials, has a constitution simpler than that of conventional ones, has sufficient skin permeability, and which permits control of skin permeability by changing the mixing ratio of two kinds of polyisobutylene having different molecular weights, a tackifier and an organic liquid. Specifically, the present invention provides a percutaneously absorbable adhesive preparation comprising a support and an adhesive layer laminated on one surface thereof, wherein the adhesive layer comprises Fentanyl, two kinds of polyisobutylene having different molecular weights, a tackifier and an organic liquid compatible with the aforementioned two kinds of polyisobutylene and the aforementioned tackifier.

Abstract: A surgical dressing comprising a pressure-sensitive adhesive tape which comprises a polytetrafluoroethylene film support having provided thereon a pressure-sensitive adhesive layer, in which the polytetrafluoroethylene film support is a uniaxially stretched porous film and the adhesive tape has a load at 50% extension of not lower than 50 g/15 mm and lower than 200 g/15 mm. The surgical dressing does not involve irritation and can be applied with easy stretch to even the part of the body having a special contour, such as the tip of a finger or a joint, with good adhesion and can follow the movement of the part to which it is stuck.

Abstract: An acrylic oily gel bioadhesive material comprising a substrate having on one surface thereof a crosslinked gel layer formed by crosslinking a composition comprising an acrylate polymer comprising as a main component an alkyl (meth)acrylate having four or more carbon atoms in the alkyl moiety and a liquid ingredient compatible with said acrylate polymer.

Abstract: An estrogen-containing gel preparation is disclosed, which comprises a substrate having on one surface thereof a crosslinked gel layer formed by crosslinking a composition comprising the following ingredients (a) to (c), the weight ratio of the ingredient (b) to the ingredient (c) being from 1.0/0.25 to 1.0/2.0:(a) estrogen;(b) an acrylate polymer; and(c) a liquid ingredient compatible with the ingredient (b).

Abstract: A percutaneous gel preparation is disclosed, which comprises a substrate having one surface thereof a crosslinked gel layer formed by crosslinking a composition comprising the following ingredients (a) to (c), the weight ratio of the ingredient (b) to the ingredient (c) being from 1.0/0.25 to 1.0/2.0:(a) isosorbide dinitrate;(b) an acrylate polymer; and(c) a liquid ingredient compatible with the ingredient (b).

Abstract: A medical adhesive comprising a plaster layer containing the following ingredients, characterized in that the ingredient 2 is incorporated in a larger amount than the ingredient 5 and in an amount not less than 25% by weight relative to the total amount of the ingredients 1.about.5, and the plaster layer is a W/O type:1 a medicinal ingredient,2 a hydrophobic polymer having a glass transition temperature (Tg) of -65.degree. C. to 35.degree. C.3 a percutaneous absorption-promoting agent,4 water, and5 a hydrophilic polymer which is soluble or capable of swelling in water; anda medical adhesive which comprises a porous base layer in the plaster layer or in contact with the plaster layer, which enable stable release of the medicinal ingredient, the percutaneous absorption-promoting agents and so on and sustaining of the pharmacological effects over a long period.

Abstract: A dermal pharmaceutical preparation comprising a soft support having provided thereon a pressure-sensitive adhesive layer containing a pressure-sensitive adhesive and a drug, wherein said pressure-sensitive adhesive is a copolymer comprising a (meth)acrylamide having an amino group as a comonomer unit. The preparation remains the drug in a dissolved state and is excellent in drug liberation and adhesion to the skin.