Patents by Inventor Yoshihito Ueno
Yoshihito Ueno has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240145646Abstract: The light emitting device has a substrate, a light emitting element arranged on the top surface of the substrate, a frame body arranged on the top surface of the substrate so as to surround the light emitting element and reflecting light from the light emitting body, and a sealing material arranged inside the frame body and sealing the light emitting element, and the frame body has a first frame portion having a first inner circumferential curved surface protruding to the side of the light emitting element and a second frame portion having a second inner circumferential curved surface, and a connection portion of the first frame portion and the second frame portion is arranged so as to have the same height as that of the top surface of the light emitting element.Type: ApplicationFiled: January 4, 2024Publication date: May 2, 2024Inventors: Kiyokazu WATANABE, Yoshihito KITTA, Yuichiro ANDO, Katsuya AOSHIMA, Ryo MATSUURA, Kohki UENO
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Publication number: 20230323355Abstract: Described herein are antiviral silencing RNA molecules (siRNAs), pharmaceutical compositions comprising same and uses thereof for the treatment of viral infections. In embodiments the siRNAs comprises chemically modification(s) for enhanced cell penetrating abilities and/or for greater nuclease resistance. Examples of chemical modifications include substituting one or more nucleotides of a native siRNA molecule with 2?-O-Methylnucleoside, 2?-Fluoronucleoside, aminoalkyl-nucleotide, aminoethyl-nucleotide, and/or 5?-aminopropyl-2?-OMe-nucleoside. The chemically modified nucleotides may be incorporated into the P strand, the G strand or both. Other possible modifications include coupling a compound such as a spermine molecule to the 5? terminus or the 3? terminus of the siRNA.Type: ApplicationFiled: September 3, 2021Publication date: October 12, 2023Applicant: SOLSTAR PHARMA INC.Inventors: Dionissios BALTZIS, Yasuhiro FURUICHI, Tokuhiro CHANO, Yoshihito UENO, Kumiko UI-TEI, Max ARELLA
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Patent number: 11780874Abstract: A nucleoside that is more practical for RNA pharmaceuticals and other applications and use thereof is represented by formula (1) or (2) below, or a salt thereof: (In formula (1), R1 represents a hydrogen atom, a hydroxyl group, a hydroxyl group in which a hydrogen atom is substituted by an alkyl group or alkenyl group, or a protected group, and in formula (2), X represents a halogen atom. In formula (1) and formula (2), R2 and R3 may be the same or different, and each represents a hydrogen atom etc., R4 represents NHR7 (in which R7 represents a hydrogen atom etc., and B represent represents any of a purine-9-yl group, 2-oxo-pyrimidin-1-yl group, substituted purine-9-yl group or substituted 2-oxo-pyrimidin-1-yl group).Type: GrantFiled: October 31, 2018Date of Patent: October 10, 2023Assignees: YAMASA CORPORATION, NATIONAL UNIVERSITY CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEMInventors: Yoshihito Ueno, Yusuke Maeda, Ryohei Kajino
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Publication number: 20230265120Abstract: A nucleoside derivative represented below, or a salt thereof. (In (1), R1 represents a hydrogen atom, a hydroxyl group or a protected group, and in (2), X represent a halogen atom. In (1) and (2), R2 and R4 each represent a hydrogen atom, a hydroxyl protecting, phosphate, or protected phosphate group, or —P(?O)nR5R6 (n is 0 or 1, R5 and R6 each representing a hydrogen atom, hydroxyl, protected hydroxyl, mercapto, protected mercapto, lower alkoxy, cyano lower alkoxy, amino or substituted amino group, when n is 1, R5 and R6 are not both hydrogen atoms), R3 represents NHR7 (R7 represents a hydrogen atom, alkyl, alkenyl or protecting group for an amino group), an azide, amidino or guanidino group, each having a linking group (when R7 is hydrogen atom, the linking group is an alkylene group), and B represents any of a purine-9-yl, 2-oxo-pyrimidin-1-yl, substituted purine-9-yl or substituted 2-oxo-pyrimidin-1-yl group.Type: ApplicationFiled: March 20, 2023Publication date: August 24, 2023Applicant: NATIONAL UNIVERSITY CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEMInventor: Yoshihito UENO
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Patent number: 11643432Abstract: A nucleoside derivative represented below, or a salt thereof. (In (1), R1 represents a hydrogen atom, a hydroxyl group or a protected group, and in (2), X represent a halogen atom. In (1) and (2), R2 and R4 each represent a hydrogen atom, a hydroxyl protecting, phosphate, or protected phosphate group, or —P(?O)nR5R6 (n is 0 or 1, R5 and R6 each representing a hydrogen atom, hydroxyl, protected hydroxyl, mercapto, protected mercapto, lower alkoxy, cyano lower alkoxy, amino or substituted amino group, when n is 1, R5 and R6 are not both hydrogen atoms), R3 represents NHR7 (R7 represents a hydrogen atom, alkyl, alkenyl or protecting group for an amino group), an azide, amidino or guanidino group, each having a linking group (when R7 is hydrogen atom, the linking group is an alkylene group), and B represents any of a purine-9-yl, 2-oxo-pyrimidin-1-yl, substituted purine-9-yl or substituted 2-oxo-pyrimidin-1-yl group).Type: GrantFiled: December 14, 2017Date of Patent: May 9, 2023Assignee: NATIONAL UNIVERSITY CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEMInventor: Yoshihito Ueno
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Publication number: 20230011179Abstract: Provided is a nucleoside derivative represented by the following formula (1): or a salt thereof, wherein R1 represents an alkoxy group, a hydrogen atom or a halogen atom; R2 and R4, which may be the same as or different from each other, each represents a hydrogen atom, a protective group for a hydroxyl group, a phosphate group, a protected phosphate group, or —P(?O)nR5R6 in which n represents 0 or 1, R5 and R6, which may be the same as or different from each other, each represents a hydrogen atom, a hydroxyl group, a protected hydroxyl group, a mercapto group, a protected mercapto group, an alkoxy group, a cyanoalkoxy group, an amino group, or a substituted amino group, provided that when n is 1, both R5 and R6 cannot be the hydrogen atom at the same time; R3 represents —(CH2)mNHR7 in which m represents an integer of 1 to 6, R7 represents a hydrogen atom, an alkyl group, an alkenyl group or a protective group for an amino group; and B represents a purin-9-yl group, a 2-oxo-pyrimidin-1-yl group, a substitType: ApplicationFiled: October 28, 2020Publication date: January 12, 2023Inventor: Yoshihito Ueno
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Publication number: 20210371447Abstract: A nucleoside derivative represented below, or a salt thereof. (In (1), R1 represents a hydrogen atom, a hydroxyl group or a protected group, and in (2), X represent a halogen atom. In (1) and (2), R2 and R4 each represent a hydrogen atom, a hydroxyl protecting, phosphate, or protected phosphate group, or —P(?O)nR5R6 (n is 0 or 1, R5 and R6 each representing a hydrogen atom, hydroxyl, protected hydroxyl, mercapto, protected mercapto, lower alkoxy, cyano lower alkoxy, amino or substituted amino group, when n is 1, R5 and R6 are not both hydrogen atoms), R3 represents NHR7 (R7 represents a hydrogen atom, alkyl, alkenyl or protecting group for an amino group), an azide, amidino or guanidino group, each having a linking group (when R7 is hydrogen atom, the linking group is an alkylene group), and B represents any of a purine-9-yl, 2-oxo-pyrimidin-1-yl, substituted purine-9-yl or substituted 2-oxo-pyrimidin-1-yl group.Type: ApplicationFiled: December 14, 2017Publication date: December 2, 2021Applicant: GIFU UNIVERSITYInventor: Yoshihito UENO
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Publication number: 20200385419Abstract: A nucleoside that is more practical for RNA pharmaceuticals and other applications and use thereof is represented by formula (1) or (2) below, or a salt thereof: (In formula (1), R1 represents a hydrogen atom, a hydroxyl group, a hydroxyl group in which a hydrogen atom is substituted by an alkyl group or alkenyl group, or a protected group, and in formula (2), X represents a halogen atom. In formula (1) and formula (2), R2 and R3 may be the same or different, and each represents a hydrogen atom etc., R4 represents NHR7 (in which R7 represents a hydrogen atom etc., and B represent represents any of a purine-9-yl group, 2-oxo-pyrimidin-1-yl group, substituted purine-9-yl group or substituted 2-oxo-pyrimidin-1-yl group).Type: ApplicationFiled: October 31, 2018Publication date: December 10, 2020Applicants: YAMASA CORPORATION, National University Corporation Tokai National Higher Education and Research SystemInventors: Yoshihito UENO, Yusuke MAEDA, Ryohei KAJINO
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Patent number: 8865898Abstract: A nucleoside analog and a salt thereof represented by any of the general formulae (1) to (10) below: wherein R1, R2, and R3 are the same or different groups, and each of the R1, R2 and R3 is selected from a hydrogen atom, a protecting group for a functional group in nucleic acid synthesis, a phosphate group, a phosphate group protected by a protecting group in nucleic acid synthesis, and an activated phosphate group for solid phase synthesis; and Ar is one of an aromatic hydrocarbon group and a polyaromatic hydrocarbon group.Type: GrantFiled: November 30, 2011Date of Patent: October 21, 2014Assignee: Japan Science and Technology AgencyInventor: Yoshihito Ueno
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Publication number: 20140221637Abstract: A nucleoside analog and a salt thereof represented by any of the general formulae (1) to (10) below: wherein R1, R2, and R3 are the same or different groups, and each of the R1, R2 and R3 is selected from a hydrogen atom, a protecting group for a functional group in nucleic acid synthesis, a phosphate group, a phosphate group protected by a protecting group in nucleic acid synthesis, and an activated phosphate group for solid phase synthesis; and Ar is one of an aromatic hydrocarbon group and a polyaromatic hydrocarbon group.Type: ApplicationFiled: November 30, 2011Publication date: August 7, 2014Inventor: Yoshihito Ueno
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Patent number: 8609826Abstract: Provided is a nucleoside derivative which has a high affinity for RNA. Use is made of a nucleoside derivative represented by either formula (1) or formula (2). (In formulae (1) and (2), Z represents a carbon atom or a nitrogen atom; R1 represents a hydrogen atom or a hydroxyl-protecting group; and R2 represents a hydrogen atom or a phosphodiester group).Type: GrantFiled: March 11, 2009Date of Patent: December 17, 2013Assignee: Japan Science and Technology AgencyInventors: Yoshihito Ueno, Yukio Kitade
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Patent number: 8354515Abstract: A labeling agent comprising a plurality of nucleotide derivative units represented by Formula (1) below: (where, Z represents a nitrogen atom or CH, Y represents an uncondensed aromatic hydrocarbon group or condensed polycyclic hydrocarbon group, X1 represents O, S or Se, and X2 represents SH (or S?), Se?, a C1-4 alkyl or a morpholino group).Type: GrantFiled: November 2, 2009Date of Patent: January 15, 2013Assignee: Japan Science and Technology AgencyInventors: Yoshihito Ueno, Yukio Kitade
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Publication number: 20120126175Abstract: The disclosures of the Specification provide an oligonucleotide derivative suited to practical use, as well as a fluorescent dye cluster and use therefor. The disclosures of the Specification use a labeling agent comprising a plurality of nucleotide derivative units represented by Formula (1) below: (where, Z represents a nitrogen atom or CH, Y represents an uncondensed aromatic hydrocarbon group or condensed polycyclic hydrocarbon group, X1 represents O, S or Se, and X2 represents SH (or S?), S or Se?, a CI-4 alkyl or a morpholino group.Type: ApplicationFiled: November 2, 2009Publication date: May 24, 2012Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCYInventors: Yoshihito Ueno, Yukio Kitade
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Publication number: 20110033863Abstract: Provided is a nucleoside derivative which has a high affinity for RNA. Use is made of a nucleoside derivative represented by either formula (1) or formula (2). (In formulae (1) and (2), Z represents a carbon atom or a nitrogen atom; R1 represents a hydrogen atom or a hydroxyl-protecting group; and R2 represents a hydrogen atom or a phosphodiester group).Type: ApplicationFiled: March 11, 2009Publication date: February 10, 2011Applicant: Japan Science and Technology AgencyInventors: Yoshihito Ueno, Yukio Kitade
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Patent number: 7629447Abstract: The invention provides a 5?-amino-2?-fluoro-2?,5?-dideoxynucleoside compound represented by the formula [1]: wherein R1 represents a nucleic acid base which may have a protecting group; R2 represents a hydrogen atom or an amino protecting group; and R3 represents a hydrogen atom or a hydroxyl protecting group. The invention also provides a dideoxynucleoside-insoluble carrier bound substance and an oligonucleotide analogue involving the dideoxynucleoside compound.Type: GrantFiled: February 26, 2007Date of Patent: December 8, 2009Assignee: Wako Pure Chemical Industries, Ltd.Inventors: Yukio Kitade, Yoshihito Ueno
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Publication number: 20080064868Abstract: The present invention discloses a 5?-amino-2?-fluoro-2?,5?-dideoxynucleoside derivative represented by the following formula [1]: (wherein R1 represents a nucleic acid base which may have a protecting group; R2 represents a hydrogen atom or a protecting group of an amino group; R3 represents a hydrogen atom or a protecting group of a hydroxyl group); a dideoxynucleoside-insoluble carrier bound substance prepared by binding said dideoxynucleoside derivative to an insoluble carrier, and an oligonucleotide analogue into which said dideoxynucleoside derivative is introduced. The oligonucleotide analogue being introduced with a dideoxynucleoside derivative of the present invention has excellent thermal stability and also high binding affinity when duplex is formed. Also, it is anticipated that it has high resistance to nucleases.Type: ApplicationFiled: February 26, 2007Publication date: March 13, 2008Applicant: Wako Pure Chemical Industries, Ltd.Inventors: Yukio Kitade, Yoshihito Ueno
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Publication number: 20070249548Abstract: It is an object to provide a nucleoside analog that can produce an oligonucleotide analog in which the two properties of chemical and biological stability, and the ability to form double strands, are excellent, and an oligonucleotide analog that includes that nucleoside analog. This is achieved by a nucleoside analog or salt thereof represented by Formula (I) below, in which, in Formula (I), R1 is any group selected from the group consisting of the group of Formula (1), the group of Formula (2), the group of Formula (3), the group of Formula (4), the group of Formula (5), the group of Formula (6), the group of Formula (7), the group of Formula (8), and any of these groups whose functional group has been protected by a protecting group, and k, l, m, and n are each independently an integer from 1 to 10.Type: ApplicationFiled: September 16, 2005Publication date: October 25, 2007Applicant: GIFU UNIVERSITYInventors: Yukio Kitade, Yoshihito Ueno