Patents by Inventor Yoshihito Yaginuma
Yoshihito Yaginuma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9095512Abstract: Spherical base granules comprising a hardly water-soluble drug and suited for film coating thereon are produced by layering spherical core particles with a drug-containing layering liquid comprising both micronized microcrystalline cellulose and an emulsifier therein and therefore having improved suspension stability.Type: GrantFiled: August 9, 2007Date of Patent: August 4, 2015Assignee: ASAHI KASEI CHEMICALS CORPORATIONInventors: Yoshihito Yaginuma, Rika Matsumoto
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Patent number: 9029427Abstract: Disclosed is a solid preparation which comprises at least one active ingredient and at least one dissolution-controlling base substance and can be formed by compression molding, wherein the dissolution-controlling base substance contains 5.0 to 99.9% by weight (inclusive) of a modified starch having a moisture retaining capacity of 400% or more and a gel indentation load of 200 g or more, containing a water-soluble ingredient in an amount of 40 to 95% by weight, having particles passing through a 75 ?m-mesh sieve in the proportion of 90% by weight or more and particles passing through a 32 ?m-mesh sieve in the proportion of 20% by weight or more, and having an average particle diameter of not smaller than 20 ?m and smaller than 50 ?m.Type: GrantFiled: November 10, 2006Date of Patent: May 12, 2015Assignee: Asahi Kasei Chemicals CorporationInventors: Masaaki Endo, Kazuhiro Obae, Ichirou Ibuki, Yoshihito Yaginuma
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Patent number: 8765187Abstract: Disclosed is an aqueous composition containing (a) an ethyl acrylate/methyl methacrylate copolymer or a plasticized vinyl accetate polymer, (b) an ethyl cellulose, (c) a water soluble additive for pharmaceutical products, (d) titanium oxide and (c) water. The solid content mass ratio among the components (a), (b), (c) and (d), namely a:b:c:d is 100:(5-50):(1-50):(0.5-10), and the solid content concentration in the aqueous composition is 0.5-40% by mass.Type: GrantFiled: July 16, 2008Date of Patent: July 1, 2014Assignee: Asahi Kasei Chemicals CorporationInventors: Yoshihito Yaginuma, Naoya Yoshida
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Patent number: 8568785Abstract: Provided is a process for producing spherical base granules comprising a easily water-soluble drug and suited for film coating by spraying a layering liquid over pharmaceutically inert spherical core particles, thereby coating the particles with a layer comprising the easily water-soluble drug, wherein (1) the spherical core particles have a microcrystalline cellulose content of 30 mass % or greater and a water absorbing capacity of 0.5 cm3/g or greater; and (2) the layering liquid is an aqueous solution comprising at least the easily water-soluble drug and a low water-soluble saccharide.Type: GrantFiled: July 18, 2007Date of Patent: October 29, 2013Assignee: Asahi Kasei Chemicals CorporationInventors: Yoshihito Yaginuma, Rika Matsumoto
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Patent number: 8367115Abstract: A process for producing a granule-containing tablet comprising mixing more than 25 mass % to 89 mass % or less of crystalline cellulose exhibiting a tensile displacement at break of 25 to 80 ?m and a relative fluidity index of 2.15 to 2.80 at a maximum compaction stress of 15 kPa, 10 to 70 mass % of spherical granules, and 20 mass % or less of a disintegrant, and then compressing the obtained mixture.Type: GrantFiled: August 26, 2008Date of Patent: February 5, 2013Assignee: Asahi Kasei Chemicals CorporationInventors: Yoshihito Yaginuma, Naoya Yoshida
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Patent number: 8349365Abstract: Disclosed is a cellooligosaccharide composition comprising, as the main ingredient, at least one cellooligosaccharide selected from the group consisting of cellobiose, cellotriose, cellotetraose, cellopentaose and cellohexaose, which is in the powdery form having an average L/D value of 3.0 or lower, a bulk density of 0.80 g/mL or lower and an angle of repose of 60° or lower.Type: GrantFiled: September 27, 2006Date of Patent: January 8, 2013Assignee: Asahi Kasei Chemicals CorporationInventors: Naoaki Yamasaki, Ichiro Ibuki, Yoshihito Yaginuma, Yoshinaga Tamura
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Patent number: 8268356Abstract: An object of the present invention is to provide an aqueous film coating solution, and the like, which has good acid resistance and sustained release properties as well as the flexibility suitable for the tablet compression force and are highly productive and cost efficient. The aqueous film coating solution of the present invention comprises an ethyl acrylate/methyl methacrylate copolymer dispersion, a methacrylic acid copolymer LD, a plasticizer, titanium oxide and water, wherein the solid mass ratio of the ethyl acrylate/methyl methacrylate copolymer dispersion, the methacrylic acid copolymer LD, the plasticizer and the titanium oxide is 100:(40 to 100):(5 to 50):(5 to 30) and the solid content thereof is 5 to 20 mass %.Type: GrantFiled: November 12, 2008Date of Patent: September 18, 2012Assignee: Asahi Kasei Chemicals CorporationInventors: Naoya Yoshida, Yoshihito Yaginuma
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Patent number: 7838666Abstract: A material is provided to give food products sufficient viscosity and stability (heat resistance, stable suspension, etc.). The material is produced from an inexpensive raw material by an economical process. Further, a novel gel containing cellulose as the main component is also provided. The present invention provides a fine fibrous water-dispersible cellulose derived from plant cell walls. For the production, a raw material having specific properties is used, and size reduction is carried out stepwise thereto. The water-dispersible cellulose can also be made into a dry composition by compounding with a water-soluble polymer or the like. This dry composition forms a gel when combined with a polysaccharide such as glucomannan or the like. The gel excels in heat-resistance and shape-retention and can be used to produce to novel food products.Type: GrantFiled: July 10, 2003Date of Patent: November 23, 2010Assignee: Asahi Kasei Kabushik KaishaInventors: Yoshihito Yaginuma, Nobuyoshi Mochihara, Yurika Tanaka, Tetsuya Ootani, Kouichirou Enatsu, Mitsuyo Akimoto, Akihiro Sakamoto
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Publication number: 20100260839Abstract: An object of the present invention is to provide an aqueous film coating solution, and the like, which has good acid resistance and sustained release properties as well as the flexibility suitable for the tablet compression force and are highly productive and cost efficient. The aqueous film coating solution of the present invention comprises an ethyl acrylate/methyl methacrylate copolymer dispersion, a methacrylic acid copolymer LD, a plasticizer, titanium oxide and water, wherein the solid mass ratio of the ethyl acrylate/methyl methacrylate copolymer dispersion, the methacrylic acid copolymer LD, the plasticizer and the titanium oxide is 100:(40 to 100):(5 to 50):(5 to 30) and the solid content thereof is 5 to 20 mass %.Type: ApplicationFiled: November 12, 2008Publication date: October 14, 2010Applicant: ASAHI KASEI CHEMICALS CORPORATIONInventors: Naoya Yoshida, Yoshihito Yaginuma
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Publication number: 20100209504Abstract: A process for producing a granule-containing tablet comprising mixing more than 25 mass % to 89 mass % or less of crystalline cellulose exhibiting a tensile displacement at break of 25 to 80 ?m and a relative fluidity index of 2.15 to 2.80 at a maximum compaction stress of 15 kPa, 10 to 70 mass % of spherical granules, and 20 mass % or less of a disintegrant, and then compressing the obtained mixture.Type: ApplicationFiled: August 26, 2008Publication date: August 19, 2010Applicant: ASAHI KASEI CHEMICALS CORPORATIONInventors: Yoshihito Yaginuma, Naoya Yoshida
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Publication number: 20100172978Abstract: Disclosed is an aqueous composition containing (a) an ethyl acrylate/methyl methacrylate copolymer or a plasticized vinyl accetate polymer, (b) an ethyl cellulose, (c) a water soluble additive for pharmaceutical products, (d) titanium oxide and (c) water. The solid content mass ratio among the components (a), (b), (c) and (d), namely a:b:c:d is 100:(5-50):(1-50):(0.5-10), and the solid content concentration in the aqueous composition is 0.5-40% by mass.Type: ApplicationFiled: July 16, 2008Publication date: July 8, 2010Applicant: ASAHI KASEI CHEMICALS CORPORATIONInventors: Yoshihito Yaginuma, Naoya Yoshida
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Publication number: 20090324802Abstract: Spherical base granules comprising a hardly water-soluble drug and suited for film coating thereon are produced by layering spherical core particles with a drug-containing layering liquid comprising both micronized microcrystalline cellulose and an emulsifier therein and therefore having improved suspension stability.Type: ApplicationFiled: August 9, 2007Publication date: December 31, 2009Applicant: ASAHL KASEI CHEMICALS CORPORATIONInventors: Yoshihito Yaginuma, Rika Matsumoto
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Publication number: 20090280186Abstract: Provided is a process for producing spherical base granules comprising a easily water-soluble drug and suited for film coating by spraying a layering liquid over pharmaceutically inert spherical core particles, thereby coating the particles with a layer comprising the easily water-soluble drug, wherein (1) the spherical core particles have a microcrystalline cellulose content of 30 mass % or greater and a water absorbing capacity of 0.5 cm3/g or greater; and (2) the layering liquid is an aqueous solution comprising at least the easily water-soluble drug and a low water-soluble saccharide.Type: ApplicationFiled: July 18, 2007Publication date: November 12, 2009Applicant: Asahi Kasei Chemicals CorporationInventors: Yoshihito Yaginuma, Rika Matsumoto
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Publication number: 20090269401Abstract: Disclosed is a solid preparation which comprises at least one active ingredient and at least one dissolution-controlling base substance and can be formed by compression molding, wherein the dissolution-controlling base substance contains 5.0 to 99.9% by weight (inclusive) of a modified starch having a moisture retaining capacity of 400% or more and a gel indentation load of 200 g or more, containing a water-soluble ingredient in an amount of 40 to 95% by weight, having particles passing through a 75 ?m-mesh sieve in the proportion of 90% by weight or more and particles passing through a 32 ?m-mesh sieve in the proportion of 20% by weight or more, and having an average particle diameter of not smaller than 20 ?m and smaller than 50 ?m.Type: ApplicationFiled: November 10, 2006Publication date: October 29, 2009Inventors: Masaaki Endo, Kazuhiro Obae, Ichirou Ibuki, Yoshihito Yaginuma
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Publication number: 20090232892Abstract: Disclosed is a cellooligosaccharide composition comprising, as the main ingredient, at least one cellooligosaccharide selected from the group consisting of cellobiose, cellotriose, cellotetraose, cellopentaose and cellohexaose, which is in the powdery form having an average L/D value of 3.0 or lower, a bulk density of 0.80 g/mL or lower and an angle of repose of 60° or lower.Type: ApplicationFiled: September 27, 2006Publication date: September 17, 2009Inventors: Naoaki Yamasaki, Ichiro Ibuki, Yoshihito Yaginuma, Yoshinaga Tamura
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Publication number: 20090196934Abstract: The characteristic in being coated with film of spherical elementary granules is improved by adjusting a short/long diameter-ratio distribution coefficient to a specific value.Type: ApplicationFiled: July 25, 2007Publication date: August 6, 2009Applicant: Asahi Kasei Chemicals CorporationInventors: Yoshihito Yaginuma, Rika Matsumoto
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Patent number: 7544379Abstract: A fine-cellulose-containing complex comprising 60 to 80 wt % of fine cellulose, 2 to 12 wt % of locust bean gum, 0.5 to 8 wt % of xanthan gum and 0 to 37.5 wt % of a hydrophilic material(s), the complex being a powder wherein the average particle size of particles formed by mild dispersion of the complex in water at 85° C. is 60 ?m or less, the proportion of particles with a particle size of 100 ?m or more among the formed particles is 30 vol % or less based on the total volume of the formed particles, and a colloid fraction in the case of vigorous dispersion of the complex in water at 25° C. is 30% or less.Type: GrantFiled: May 29, 2002Date of Patent: June 9, 2009Assignee: Asahi Kasei Kabushiki KaishaInventors: Yasushi Kawamura, Yuka Itou, Nobuyoshi Mochihara, Yoshihito Yaginuma, Kouichi Noda, Akihiro Sakamoto
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Publication number: 20050272836Abstract: A material is provided to give food products sufficient viscosity and stability (heat resistance, stable suspension, etc.). The material is produced from an inexpensive raw material by an economical process. Further, a novel gel containing cellulose as the main component is also provided. The present invention provides a fine fibrous water-dispersible cellulose derived from plant cell walls. For the production, a raw material having specific properties is used, and size reduction is carried out stepwise thereto. The water-dispersible cellulose can also be made into a dry composition by compounding with a water-soluble polymer or the like. This dry composition forms a gel when combined with a polysaccharide such as glucomannan or the like. The gel excels in heat-resistance and shape-retention and can be used to produce to novel food products.Type: ApplicationFiled: July 10, 2003Publication date: December 8, 2005Applicant: ASAHI KASEI KABUSHIKI KAISHAInventors: Yoshihito Yaginuma, Nobuyoshi Mochihara, Yurika Tanaka, Tetsuya Ootani, Kouichirou Enatsu, Mitsuyo Akimoto, Akihiro Sakamoto
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Publication number: 20040137138Abstract: A fine-cellulose-containing complex comprising 60 to 80 wt % of fine cellulose, 2 to 12 wt % of locust bean gum, 0.5 to 8 wt % of xanthan gum and 0 to 37.5 wt % of a hydrophilic material(s), said complex being such powder that the average particle size of particles formed by mild dispersion of the complex in water at 85° C. is 60 &mgr;m or less, the proportion of particles with a particle size of 100 &mgr;m or more among the formed particles is 30 vol % or less based on the total volume of the formed particles, and a colloid fraction in the case of vigorous dispersion of the complex in water at 25° C. is 30% or less.Type: ApplicationFiled: November 26, 2003Publication date: July 15, 2004Inventors: Yasushi Kawamura, Yuka Itou, Nobuyoshi Mochihara, Yoshihito Yaginuma, Kouchi Noda, Akihiro Sakamoto
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Patent number: RE45810Abstract: Provided is a process for producing spherical base granules comprising a easily water-soluble drug and suited for film coating by spraying a layering liquid over pharmaceutically inert spherical core particles, thereby coating the particles with a layer comprising the easily water-soluble drug, wherein (1) the spherical core particles have a microcrystalline cellulose content of 30 mass % or greater and a water absorbing capacity of 0.5 cm3/g or greater; and (2) the layering liquid is an aqueous solution comprising at least the easily water-soluble drug and a low water-soluble saccharide.Type: GrantFiled: July 31, 2014Date of Patent: November 24, 2015Assignee: ASAHI KASEI CHEMICALS CORPORATIONInventors: Yoshihito Yaginuma, Rika Matsumoto