Abstract: A center portion (30) of a V-shaped cutter blade (20) includes center large teeth (31) and center middle teeth 32 the tooth height of which is less than the tooth height of the center large teeth (31). End portions (50) of the cutter blade (20) each include first end teeth (51) and second end teeth (52) the tooth height of which is less than the tooth height of the first end teeth (51). Tooth tops of the first end teeth 51 of each end portion (50) are located on a straight line (L1), which extends through tooth tops of the center large teeth (31) located on one of the right half and the left half of the center portion (30).

Abstract: In the production of an aliphatic polyester by ring-opening polymerization of a cyclic ester, at least a latter period of polymerization is proceeded with by way of solid-phase polymerization, and the resultant aliphatic polyester is subjected to removal of residual cyclic ester. As a result, an aliphatic polyester with a minimized content of residual monomer is obtained.

Abstract: A wrapping film container, including: an elongated container body for housing therein a rolled self-tacky wrapping film, an opening provided to the container body along a longitudinal direction of the container body for pulling out a portion of the wrapping film therethrough, cutting means for cutting the pulled-out portion of the wrapping film and a film-holding section provided on a front face of the container body for preventing re-winding to an inside of the container, wherein the film-holding section comprises a laminate structure including a pressure-sensitive adhesive layer, a substrate layer, an adhesive layer and a self-tacky film layer, disposed sequentially from the container body side.

Abstract: A wrapping film container, including: an elongated container body for housing therein a rolled self-tacky wrapping film, an opening provided to the container body along a longitudinal direction of the container body for pulling out a portion of the wrapping film therethrough, cutting means for cutting the pulled-out portion of the wrapping film and a film-holding section provided on a front face of the container body for preventing re-winding to an inside of the container, wherein the film-holding section comprises a laminate structure including a pressure-sensitive adhesive layer, a substrate layer, an adhesive layer and a self-tacky film layer, disposed sequentially from the container body side.

Abstract: A center portion (30) of a V-shaped cutter blade (20) includes center large teeth (31) and center middle teeth 32 the tooth height of which is less than the tooth height of the center large teeth (31). End portions (50) of the cutter blade (20) each include first end teeth (51) and second end teeth (52) the tooth height of which is less than the tooth height of the first end teeth (51). Tooth tops of the first end teeth 51 of each end portion (50) are located on a straight line (L1), which extends through tooth tops of the center large teeth (31) located on one of the right half and the left half of the center portion (30).

Abstract: A cutting edge 24 is divided into a center area 28 including a V-shaped apex portion, a pair of intermediate areas 29 on the outer sides thereof, and a pair of side areas 30 on the farther outer sides thereof. The center area 28 has first teeth with the highest tooth height and second teeth with a smaller tooth height, the first teeth being situated at the apex portion and the second teeth being situated between the first teeth at a prescribed spacing around them as the center. A first straight line connecting the tips of the first teeth, a second straight line connecting the tips of the second teeth and a third straight line connecting the bases of the first teeth and second teeth are parallel, the second straight line being located between the first straight line and third straight line. The tips of the intermediate teeth of the intermediate area 29 are located on the second straight line or between the second straight line and third straight line.

Abstract: The immunoassay element for quantitatively analyzing an antigen by determining the change in enzymatic activity of an enzyme-labelled antigen or antibody caused by an immunological reaction. The immunoassay element comprises a substrate layer containing a non-diffusible substrate which forms a diffusible material in the presence of the labelling enzyme, and a reagent layer containing a fragmenting enzyme for further fragmenting the diffusible material into a lower molecular weight product. As the non-diffusible substrate, a substrate capable of reacting solely with the labelling enzyme and incapable of reacting the fragmenting enzyme is utilized. When an endo-active glucosidase is used as the labelling enzyme, and an exo-active glucosidase is used the fragmenting enzyme in the reagent layer, the non-diffusible substrate of the substrate layer is preferred to be an endo type selectively reactive substrate, which means a substrate having a reactivity specific to endo-active glucosidase.

Abstract: In the production of an aliphatic polyester by ring-opening polymerization of a cyclic ester, at least a latter period of polymerization is proceeded with by way of solid-phase polymerization, and the resultant aliphatic polyester is subjected to removal of residual cyclic ester. As a result, an aliphatic polyester with a minimized content of residual monomer is obtained.

Abstract: This invention relates to a dry analytical element using a water-soluble indicator which improves measuring accuracy, which comprises a water-impermeable support, a water-permeable layer and a spreading layer having a function to spread a liquid uniformly, wherein a water-soluble indicator for colorimetry is incorporated into the s preading layer.

Abstract: A plasma- or serum-collecting device with simple structure and easy to handle is provided. The device comprises a vacuum blood drawing tube accommodating a blood-filtering unit, wherein the vacuum tube contains a space above the blood-filtering unit to preserve blood to be filtered and a partition wall under the blood-filtering unit to keep a backspace at reduced pressure, and the blood-filtering unit contains a communicating needle to break the partition wall at the bottom.

Abstract: The immunoassay element for quantitatively analyzing an antigen by determining the change in enzymatic activity of an enzyme-labelled antigen or antibody caused by an immunological reaction. The immunoassay element comprises a substrate layer containing a non-diffusible substrate which forms a diffusible material in the presence of the labelling enzyme, and a reagent layer containing a fragmenting enzyme for further fragmenting the diffusible material into a lower molecular weight product. As the non-diffusible substrate, a substrate capable of reacting solely with the lebelling enzyme and incapable of reacting the fragmenting enzyme is utilized. When an endo-active glucosidase is used as the labelling enzyme, and an exo-active glucosidase is used the fragmenting enzyme in the reagent layer, the non-diffusible substrate of the substrate layer is preferred to be an endo type selectively reactive substrate, which means a substrate having a reactivity specific to endo-active glucosidase.

Abstract: The invention provides a rapid, convenient, and automatable method for extracting a highly pure nucleic acid in order to carry out nucleic acid analysis smoothly with high accuracy in an array method. An analyzing method includes analyzing a nucleic acid by an array method, the nucleic acid being separated and purified by a separation and purification method which includes the steps of (a) to (f) identified in the specification.

Abstract: The immunoassay element for quantitatively analyzing an antigen by determining the change in enzymatic activity of an enzyme-labelled antigen or antibody caused by an immunological reaction. The immunoassay element comprises a substrate layer containing a non-diffusible substrate which forms a diffusible material in the presence of the labelling enzyme, and a reagent layer containing a fragmenting enzyme for further fragmenting the diffusible material into a lower molecular weight product. As the non-diffusible substrate, a substrate capable of reacting solely with the lebelling enzyme and incapable of reacting the fragmenting enzyme is utilized. When an endo-active glucosidase is used as the labelling enzyme, and an exo-active glucosidase is used the fragmenting enzyme in the reagent layer, the non-diffusible substrate of the substrate layer is preferred to be an endo type selectively reactive substrate, which means a substrate having a reactivity specific to endo-active glucosidase.

Abstract: A set of a plurality of biochemical analysis units having porous adsorptive regions, to which ligands or receptors have been bound respectively, are used simultaneously and arrayed in series with respect to a direction of flow of a reaction liquid containing at least one kind of a receptor or at least one kind of a ligand. The single same reaction liquid is forcibly caused to flow such that the reaction liquid flows across each of the porous adsorptive regions of the set of the plurality of the biochemical analysis units. The receptor or the ligand is thus subjected to specific binding with the ligands or the receptors having been bound to the porous adsorptive regions of the biochemical analysis units and is then detected by the utilization of a labeling substance.

Abstract: An agglutination assay method for quantitatively determination of an analyte in a liquid sample using particles bearing an anti-analyte. A non-fluid substance which retains the particles while suppressing the diffusion of the particles therein is used as a medium which is to be a place where the agglutination of the particles takes place. Upon analysis, a solation agent is added to the non-fluid substance medium to increase the fluidity of the non-fluid substance, thereby the particles bearing the anti-analyte can diffuse in the medium to cause the agglutination with the analyte. Preferably, the solation agent is added to the non-fluid medium together with the sample. The non-fluid substance medium containing the particle-labeled anti-analyte can be stored with a higher stability in the dry state. A dry analysis element for enabling such analysis method is also provided.

Abstract: A composite ion selective electrode comprising a calcium ion selective electrode member and a hydrogen ion selective electrode member which is characterized in that a calcium ion selective membrane of the calcium ion selective electrode member has a thickness of 5 to 30 &mgr;m, and the hydrogen ion selective membrane of the hydrogen ion selective electrode member contains tri-n-dodecyl-amine and trisethylhexyl trimellitate. Each of the calcium ion selective electrode member and the hydrogen ion selective electrode member can be employed singly.

Abstract: A biochemical analysis unit comprises a base plate, which has a plurality of holes and is constituted of a material having radiation attenuating properties and/or light attenuating properties, and a porous adsorptive material, which is filled in each of the plurality of the holes of the base plate and forms each of a plurality of adsorptive regions. The porous adsorptive material, which forms each of the plurality of the adsorptive regions, has a pore diameter falling within the range of 1 &mgr;m to 10 &mgr;m. The porous adsorptive material may take on the form of a film.

Abstract: A dry analytical element for calorimetric or turbidity analysis comprising a water-impermeable sheet that comprises an analyte storable area containing a necessary reagent for a designed analysis in dry state, wherein a specimen containing an analyte develops to the whole planar directions in substantially equal volume when it is supplied on the sheet.

Abstract: A plasma- or serum-collecting device with simple structure and easy to handle is provided. The device comprises a vacuum blood drawing tube accommodating a blood-filtering unit, wherein the vacuum tube contains a space above the blood-filtering unit to preserve blood to be filtered and a partition wall under the blood-filtering unit to keep a backspace at reduced pressure, and the blood-filtering unit contains a communicating needle to break the partition wall at the bottom.

Abstract: A plasma-collecting devise comprises a blood-filtering element having a blood-drawing needle and a communicating needle, a vacuum blood-drawing tube, and a contracting and expanding element connecting the blood-filtering unit and the vacuum blood-drawing tube. The device enables blood drawing from blood vessel and blood filtering continuously to obtain plasma.