Patents by Inventor Yoshikazu Kikumoto

Yoshikazu Kikumoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IL-1.beta. and derivatives thereof and drugs
    Patent number: 6107465
    Abstract: A homogeneous interleukin 1.beta. (IL-1.beta.), its derivative having a modified amino acid sequence of IL-1.beta., a gene coding for said derivative, medical composition comprising said derivative as a pharmaceutically effective component and a medicinal use of homogeneous IL-1.beta. and the derivative.
    Type: Grant
    Filed: March 10, 1987
    Date of Patent: August 22, 2000
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Satoru Nakai, Mayumi Kaneta, Yoshikazu Kikumoto, Yeong-Man Hong, Kazuyoshi Kawai, Setsuko Takegata, Kiyoshi Ishii, Yasuo Yanagihara, Yoshikatsu Hirai
  • DNA encoding interleukin IL-1.beta. mutant
    Patent number: 5847098
    Abstract: A homogeneous interleukin 1.beta. (IL-1.beta.), its derivative having a modified amino acid sequence of IL-1.beta., a gene coding for said derivative, medical composition comprising said derivative as a pharmaceutically effective component and a medicinal use of homogeneous IL-1.beta. and the derivative.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 8, 1998
    Assignee: Otsuka Pharmaceutcal Co., Ltd.
    Inventors: Satoru Nakai, Mayumi Kaneta, Yoshikazu Kikumoto, Yeong-Man Hong, Kazuyoshi Kawai, Setsuko Takegata, Kiyoshi Ishii, Yasuo Yanagihara, Yoshikatsu Hirai
  • Methods of use of IL-1.alpha.
    Patent number: 5702698
    Abstract: Methods are disclosed for promoting production of colony stimulating factor and inhibiting growth of Meth A tumor cells comprising administering a pharmaceutically effective amount of modified IL-1.alpha. to a subject.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: December 30, 1997
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Satoru Nakai, Mayumi Kaneta, Yoshikazu Kikumoto, Yeong-Man Hong, Kazuyoshi Kawai, Setsuko Takegata, Kiyoshi Ishii, Yasuo Yanagihara, Yoshikatsu Hirai
  • Method and use of IL-1.alpha.
    Patent number: 5543140
    Abstract: Methods for stimulating immunity, inhibiting tumor growth, promoting production of a cytokine, and preventing or inhibiting radiation injury by administration of Interleukin-1.alpha. (IL-1.alpha.) derivatives, are disclosed.
    Type: Grant
    Filed: June 1, 1994
    Date of Patent: August 6, 1996
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Satoru Nakai, Mayumi Kaneta, Yoshikazu Kikumoto, Yeong-Man Hong, Kazuyoshi Kawai, Setsuko Takegata, Kiyoshi Ishii, Yasuo Yanagihara, Yoshikatsu Hirai
  • Gene that encodes for polypeptides of IL-1.alpha.
    Patent number: 5371204
    Abstract: An interleukin-1.alpha. (IL-1.alpha.) derivative having a modified amino acid sequence of IL-1.alpha., a gene coding for said derivative, medicinal composition comprising said derivative as a pharmaceutically effective component and a medicinal use of homogeneous IL-1.alpha..
    Type: Grant
    Filed: January 22, 1991
    Date of Patent: December 6, 1994
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Satoru Nakai, Mayumi Kaneta, Yoshikazu Kikumoto, Yeong-Man Hong, Kazuyoshi Kawai, Setsuko Takegata, Kiyoshi Ishii, Yasuo Yanagihara, Yoshikatsu Hirai
  • IL-1.alpha. derivatives and drugs
    Patent number: 5008374
    Abstract: An interleukin-1.alpha. (IL-1.alpha.) derivative having a modified amino acid sequence of IL-1.alpha., a gene coding for said derivative, medicinal composition comprising said derivative as a pharmaceutically effective component and a medicinal use of homogeneous IL-1.alpha..
    Type: Grant
    Filed: March 9, 1987
    Date of Patent: April 16, 1991
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Satoru Nakai, Mayumi Kaneta, Yoshikazu Kikumoto, Yeong-Man Hong, Kazuyoshi Kawai, Setsuko Takegata, Kiyoshi Ishii, Yasuo Yanagihara, Yoshikatsu Hirai
  • Antitumor active substance, process for preparing the same, drug containing the substance, gene coding for the substance, vector containing the gene and recombinant microorganism
    Patent number: 4898818
    Abstract: This invention provides an antitumor active substance GIF, a process for preparing the same, an antitumor composition containing the substance, a gene coding for GIF, a vector containing the gene and a recombinant microorganism, the substance GIF comprises as its component protein polypeptide A of the following primary structure. ##STR1## wherein X is Cys or Ser and Z is H or a peptide represented by the amino acid sequence ##STR2## or a peptide having the above sequence wherein at least one amino acid is removed from the N terminal or an amino acid.
    Type: Grant
    Filed: December 19, 1985
    Date of Patent: February 6, 1990
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Satoru Nakai, Mayumi Kaneta, Yoshikazu Kikumoto, Yeong-Man Hong, Kazuyoshi Kawai, Setsuko Takegata, Kiyoshi Ishii, Yasuo Yanagihara, Yoshikatsu Hirai