Patents by Inventor Yoshikazu Okamura
Yoshikazu Okamura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11125742Abstract: Provided is a non-specific reaction inhibitor for achieving the accurate detection and quantitation of a trace component (a target substance) contained in a sample, in an immunoassay, by simply and effectively inhibiting a non-specific reaction associated with the measurement. The non-specific reaction inhibitor comprises a substance of the formula I: wherein R1 and R2 together form a double bond between carbons, to which they are respectively bonded directly, or R1 is a hydrogen atom and R2 is a group formed by removing H from an SH-group-containing compound, B is a support, and L is a spacer arm portion.Type: GrantFiled: June 28, 2012Date of Patent: September 21, 2021Assignee: LSI MEDIENCE CORPORATIONInventors: Yoshikazu Okamura, Shigeru Tashiro
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Patent number: 11041864Abstract: Disclosed is a prediction method for the prognosis of sepsis comprising measuring an sCD14-ST level in a sample. sCD14-ST, to be measured in the present invention, is a marker superior to procalcitonin, known as a marker to predict the prognosis in sepsis patients.Type: GrantFiled: January 10, 2012Date of Patent: June 22, 2021Assignees: LSI MEDIENCE CORPORATION, MOCHIDA PHARMACEUTICAL CO., LTD.Inventors: Takeshi Matsuya, Yoshikazu Okamura, Ralf Thomae, Eberhard Spanuth, Boris Ivandic, Kamon Shirakawa, Shigeatsu Endo
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Patent number: 10634681Abstract: Disclosed are a method for immunologically measuring cardiac troponin in a biological sample, in which the formation of an immunological complex of cardiac troponin with an antibody specifically binding thereto is performed in the presence of a divalent cation at 4 mmol/L or more; and a kit for measuring cardiac troponin, comprising an antibody specifically binding to cardiac troponin, and a buffer containing a divalent cation at a high concentration. According to the method or the kit, a stable and highly-accurate measured value can be obtained without being affected by interfering substances in a specimen regardless of the type of specimen.Type: GrantFiled: February 24, 2012Date of Patent: April 28, 2020Assignee: LSI MEDIENCE CORPORATIONInventor: Yoshikazu Okamura
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Publication number: 20140193842Abstract: Provided is a non-specific reaction inhibitor for achieving the accurate detection and quantitation of a trace component (a target substance) contained in a sample, in an immunoassay, by simply and effectively inhibiting a non-specific reaction associated with the measurement. The non-specific reaction inhibitor comprises a substance of the formula I: wherein R1 and R2 together form a double bond between carbons, to which they are respectively bonded directly, or R1 is a hydrogen atom and R2 is a group formed by removing H from an SH-group-containing compound, B is a support, and L is a spacer arm portion.Type: ApplicationFiled: June 28, 2012Publication date: July 10, 2014Applicant: MITSUBISHI CHEMICAL MEDIENCE CORPORATIONInventors: Yoshikazu Okamura, Shigeru Tashiro
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Publication number: 20130330841Abstract: Disclosed are a method for immunologically measuring cardiac troponin in a biological sample, in which the formation of an immunological complex of cardiac troponin with an antibody specifically binding thereto is performed in the presence of a divalent cation at 4 mmol/L or more; and a kit for measuring cardiac troponin, comprising an antibody specifically binding to cardiac troponin, and a buffer containing a divalent cation at a high concentration. According to the method or the kit, a stable and highly-accurate measured value can be obtained without being affected by interfering substances in a specimen regardless of the type of specimen.Type: ApplicationFiled: February 24, 2012Publication date: December 12, 2013Applicant: Mitsubishi Chemical Medience CorporationInventor: Yoshikazu Okamura
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Publication number: 20130288276Abstract: Disclosed is a prediction method for the prognosis of sepsis comprising measuring an sCD14-ST level in a sample. sCD14-ST, to be measured in the present invention, is a marker superior to procalcitonin, known as a marker to predict the prognosis in sepsis patients.Type: ApplicationFiled: January 10, 2012Publication date: October 31, 2013Applicants: MOCHIDA PHARMACEUTICAL CO., LTD., Mitsubishi Chemical Medience CorporationInventors: Takeshi Matsuya, Yoshikazu Okamura, Ralf Thomae, Eberhard Spanuth, Boris Ivandic, Kamon Shirakawa, Shigeatsu Endo
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Patent number: 8383421Abstract: An object of the present invention is to provide a cartridge for automatic measurement used in an automatic measuring device, capable of automatically performing measurement including heat treatment of a sample, and a measuring device using the cartridge. The present invention relates to a cartridge for use in measuring a component to be measured contained in a sample, comprising: at least a heat-treatment well for performing heat treatment of the sample; and a reaction well for reacting the component to be measured in the sample with a material specifically reacting therewith.Type: GrantFiled: January 17, 2006Date of Patent: February 26, 2013Assignee: Mitsubishi Chemical Medience CorporationInventors: Atsushi Yanagida, Takashi Kurihara, Hiroyuki Yokoi, Atsushi Koyata, Yoshikazu Okamura, Daishi Miyamoto
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Publication number: 20130011856Abstract: An object of the present invention is to provide a cartridge for automatic measurement used in an automatic measuring device, capable of automatically performing measurement including heat treatment of a sample, and a measuring device using the cartridge. The present invention relates to a cartridge for use in measuring a component to be measured contained in a sample, comprising: at least a heat-treatment well for performing heat treatment of the sample; and a reaction well for reacting the component to be measured in the sample with a material specifically reacting therewith.Type: ApplicationFiled: September 14, 2012Publication date: January 10, 2013Applicant: MITSUBISHI KAGAKU IATRON, INC.Inventors: Atsushi YANAGIDA, Takashi KURIHARA, Hiroyuki YOKOI, Atsushi KOYATA, Yoshikazu OKAMURA, Daishi MIYAMOTO
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Publication number: 20120309025Abstract: An analysis method capable of accurately measuring human sCD14-ST when using a whole blood sample is provided. In the analysis method, human sCD14-ST in a whole blood sample is analyzed within 6 hours of the collection of the sample.Type: ApplicationFiled: January 28, 2011Publication date: December 6, 2012Applicant: MOCHIDA PHARMACEUTICAL CO., LTDInventors: Yoshikazu Okamura, Hiroyuki Yokoi
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Patent number: 7749722Abstract: A method for measuring an analyte in a whole blood sample comprising the steps of (1) bringing the whole blood sample into contact with a first substance which is carried on an insoluble carrier and specifically binds to the analyte to be measured and a second substance which is labeled with an alkaline phosphatase and specifically binds to the analyte to be measured, and (2) measuring a resulting complex on the basis of an enzyme reaction of the alkaline phosphatase, the measuring step (2) being carried out in the presence of an inhibitor of endogenous alkaline phosphatases, is disclosed.Type: GrantFiled: December 15, 2005Date of Patent: July 6, 2010Assignee: Mitsubishi Kagaku Istron, Inc.Inventors: Yoshikazu Okamura, Takashi Kurihara, Hiroyuki Yokoi, Junichi Ogawa
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Publication number: 20070141645Abstract: A method for measuring an analyte in a whole blood sample comprising the steps of (1) bringing the whole blood sample into contact with a first substance which is carried on an insoluble carrier and specifically binds to the analyte to be measured and a second substance which is labeled with an alkaline phosphatase and specifically binds to the analyte to be measured, and (2) measuring a resulting complex on the basis of an enzyme reaction of the alkaline phosphatase, the measuring step (2) being carried out in the presence of an inhibitor of endogenous alkaline phosphatases, is disclosed.Type: ApplicationFiled: December 15, 2005Publication date: June 21, 2007Applicant: MITSUBISHI KAGAKU IATRON, INC.Inventors: Yoshikazu Okamura, Takashi Kurihara, Hiroyuki Yokoi, Junichi Ogawa
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Publication number: 20060183217Abstract: An object of the present invention is to provide a cartridge for automatic measurement used in an automatic measuring device, capable of automatically performing measurement including heat treatment of a sample, and a measuring device using the cartridge. The present invention relates to a cartridge for use in measuring a component to be measured contained in a sample, comprising: at least a heat-treatment well for performing heat treatment of the sample; and a reaction well for reacting the component to be measured in the sample with a material specifically reacting therewith.Type: ApplicationFiled: January 17, 2006Publication date: August 17, 2006Applicant: MITSUBISHI KAGAKU IATRON, INC.Inventors: Atsushi Yanagida, Takashi Kurihara, Hiroyuki Yokoi, Atsushi Koyata, Yoshikazu Okamura, Daishi Miyamoto