Abstract: RNA molecules for RNA interference to target a mutant allele with a point mutation, wherein the molecule has a nucleotide sequence complementary to a nucleotide sequence of a coding region of the mutant allele; and when counted from the base at the 5?-end in the nucleotide sequence complementary to the sequence of the mutant allele: a base at position 5 or 6 is mismatched with a base in the mutant allele; a base at position 10 or 11 is at the position of the point mutation and is identical to the base at the position of the point mutation in the mutant allele; the group at the 2?-position of the pentose in the ribonucleotide at position 8 is modified with OCH3, halogen, or LNA; and the group at the 2?-position of the pentose in the ribonucleotide at position 7 is not modified with any of OCH3, halogen, and LNA.

Abstract: The present invention is directed to provide novel RNA molecules, chimeric NA molecules, double-stranded RNA molecules, and double-stranded chimeric NA molecules. Specifically, an embodiment of the present invention is an RNA molecule for RNA interference to target a mutant allele with a point mutation, in which (1) the molecule has a nucleotide sequence complementary to a nucleotide sequence of a coding region of the mutant allele; and (2) when counted from the base at the 5?-end in a nucleotide sequence complementary to a nucleotide sequence of the mutant allele, (2-1) a base at position 5 or 6 is mismatched to a base in the mutant allele; (2-2) a position 10 or 11 corresponds to the position of the point mutation; and (2-3) a group at the 2?-position of a pentose at positions 6-8 or positions 7 and 8 is modified with, e.g., OCH3. In this RNA molecule, one or more ribonucleotides may be replaced by, e.g., a deoxyribonucleotide. The molecule may form a double-stranded RNA with a complementary strand.

Abstract: A grille shutter device includes: a first bumper reinforcement extending in a vehicle width direction; and a shutter mechanism that is provided with a plurality of support members extending from the first bumper reinforcement in a direction intersecting with the vehicle width direction, is supported by the plurality of support members, and regulates a flow rate of air which flows into an engine room from a grille.

Abstract: A grille shutter device includes: a first bumper reinforcement extending in a vehicle width direction; and a shutter mechanism that is provided with a plurality of support members extending from the first bumper reinforcement in a direction intersecting with the vehicle width direction, is supported by the plurality of support members, and regulates a flow rate of air which flows into an engine room from a grille.

Abstract: A shutter mechanism is adapted to be provided to a grill opening in a vehicle body. Opening and closing operations of the shutter mechanism are controlled by an electronic control unit (ECU). The ECU determines whether a vehicle is in a traveling end state. If the vehicle is in the traveling end state, the ECU determines whether or not the shutter mechanism is in an open state. If the ECU determines that the open state of the shutter mechanism cannot be confirmed, the ECU controls the shutter mechanism to open the shutter mechanism.

Abstract: A grille apparatus for a vehicle includes a first cover arranged at an opening portion of a front grille, a second cover arranged at the opening portion of the front grille, and a drive mechanism changing a relative position of the first cover and the second cover in response to a driving force of a drive source, in which the drive mechanism changes an opening amount of the front grille by performing an opening operation moving the second cover to a rear of the first cover, and by performing a closing operation returning the second cover to a fully-closed position, the fully-closed position before moving the second cover to the rear of the first cover while maintaining the first cover and the second cover within the opening portion of the front grille.

Abstract: A spoiler unit includes a movable spoiler for a vehicle, a frame fixing the movable spoiler to the vehicle, and a cover being mounted on the frame.

Abstract: A spoiler device includes a movable spoiler for a vehicle, the movable spoiler being movable between a retracted position and a deployed position, a link mechanism supporting the movable spoiler, a torsion bar connected to the link mechanism, and an actuation portion rotating the torsion bar.

Abstract: A spoiler device for a vehicle includes a spoiler, a support mechanism supporting the spoiler, the support mechanism adjusting the spoiler to be positioned at a deployed position where the spoiler protrudes from an outer surface of the vehicle, the support mechanism adjusting the spoiler to be positioned at a retracted position where the spoiler is retracted within a housing recessed portion, the housing recessed portion being formed at the outer surface of the vehicle, a fixing member fixing the spoiler to the support mechanism, and a first tubular member and a second tubular member into which the fixing member is inserted, the first tubular member being provided with a first threaded portion at a first circumferential surface, the second tubular member being provided with a second threaded portion at a second circumferential surface, the first threaded portion and the second threaded portion being threadedly engaged with each other.

Abstract: A spoiler device for a vehicle includes a spoiler, a support mechanism supporting the spoiler, the support mechanism adjusting the spoiler to be positioned at a deployed position where the spoiler protrudes from an outer surface of the vehicle, the support mechanism adjusting the spoiler to be positioned at a retracted position where the spoiler is retracted within a housing recessed portion, the housing recessed portion being formed at the outer surface of the vehicle, a fixing member fixing the spoiler to the support mechanism, and a first tubular member and a second tubular member into which the fixing member is inserted, the first tubular member being provided with a first threaded portion at a first circumferential surface, the second tubular member being provided with a second threaded portion at a second circumferential surface, the first threaded portion and the second threaded portion being threadedly engaged with each other.

Abstract: A spoiler unit includes a movable spoiler for a vehicle, a frame fixing the movable spoiler to the vehicle, and a cover being mounted on the frame.

Abstract: A spoiler device includes a movable spoiler for a vehicle, the movable spoiler being movable between a retracted position and a deployed position, a link mechanism supporting the movable spoiler, a torsion bar connected to the link mechanism, and an actuation portion rotating the torsion bar.

Abstract: A grille shutter control device is provided with a control section configured so as to open and close a shutter adapted to be provided in an air introduction path for introducing air ahead of the vehicle into an engine compartment. The grille shutter control device drives and controls first and second drive units. The grille shutter control device is provided with: an abnormality detecting section configured to detect an abnormality in the operation of the shutter on the basis of the condition of the shutter after the start of operation thereof; and an informing section for informing, on the basis of an abnormality in the operation detected by the abnormality detection section, the user of the abnormality in the operation of the shutter.

Abstract: Provided is a grill shutter device including a shutter mechanism controlling a flow rate of air flowing into a vehicle body from the grill opening portion of the vehicle body front portion by an opening and closing operation; a frame configured to support the shutter mechanism within the grill opening portion; an actuator that is held in the frame and performs the opening and closing driving of the shutter mechanism; and a holding structure capable of relatively moving the actuator to the front side of the frame, based on the collision load at the time of the vehicle collision.

Abstract: A grille shutter apparatus includes a shutter mechanism including plural of movable fins and at least one connection mechanism independently arranged to connect every two of the movable fins adjacent to one another. Accordingly, the shutter mechanism makes the movable fins operate in conjunction with one another. The grille shutter apparatus further includes a control portion controlling a flow rate of air flowing from a grille opening portion formed at a front portion of a vehicle body into the vehicle body on the basis of opening and closing operations of the shutter mechanism, and a detection device detecting an operational state of the shutter mechanism on the basis of an operation of the movable fins which correspond to a most downstream portion of a serially-arranged driving force transmission path formed at the shutter mechanism.

Abstract: A shutter mechanism is adapted to be provided to a grill opening in a vehicle body. Opening and closing operations of the shutter mechanism are controlled by an electronic control unit (ECU). The ECU determines whether a vehicle is in a traveling end state. If the vehicle is in the traveling end state, the ECU determines whether or not the shutter mechanism is in an open state. If the ECU determines that the open state of the shutter mechanism cannot be confirmed, the ECU controls the shutter mechanism to open the shutter mechanism.

Abstract: A grille apparatus for a vehicle includes a first cover arranged at an opening portion of a front grille, a second cover arranged at the opening portion of the front grille, and a drive mechanism changing a relative position of the first cover and the second cover in response to a driving force of a drive source, in which the drive mechanism changes an opening amount of the front grille by performing an opening operation moving the second cover to a rear of the first cover, and by performing a closing operation returning the second cover to a fully-closed position, the fully-closed position before moving the second cover to the rear of the first cover while maintaining the first cover and the second cover within the opening portion of the front grille.

Abstract: An open/close actuating mechanism control device for a vehicle includes: an actuating mechanism (24, 30) that is exposed to outside air and that opens or closes on the basis of whether a predetermined condition is satisfied; an open/close failure determining unit (32) that determines whether an open/close failure of the actuating mechanism (24, 30), in which the actuating mechanism (24, 30) fails to open or close, has occurred; an outside air temperature detecting unit (26, 32) that detects an outside air temperature; and a determination timing changing unit (32) that changes timing, at which the open/close failure determining unit (32) determines that the open/close failure of the actuating mechanism (24, 30) has occurred, on the basis of the outside air temperature detected by the outside air temperature detecting unit (26, 32).

Abstract: A movable grille shutter for a vehicle includes a fin adapted to be provided at a grille opening portion and being operated so as to freely open or close the grille opening portion through which ambient air is taken in, a drive source for driving the fin, a driving force transmitting mechanism for transmitting a driving force from the drive source to the fin and a flexible member being linked to the driving force transmitting mechanism and being deformed for operating the fin to open the grille opening portion in a case where a load that is equal to or more than a predetermined value is acted thereon.

Abstract: A grille shutter apparatus includes a shutter mechanism including plural of movable fins and at least one connection mechanism independently arranged to connect every two of the movable fins adjacent to one another. Accordingly, the shutter mechanism makes the movable fins operate in conjunction with one another. The grille shutter apparatus further includes a control portion controlling a flow rate of air flowing from a grille opening portion formed at a front portion of a vehicle body into the vehicle body on the basis of opening and closing operations of the shutter mechanism, and a detection device detecting an operational state of the shutter mechanism on the basis of an operation of the movable fins which correspond to a most downstream portion of a serially-arranged driving force transmission path formed at the shutter mechanism.