Abstract: An RNA methyltransferase inhibitor comprising sulfonamide-based compounds and/or pyrazoline-based compounds is provided

Abstract: According to one embodiment, a diagnostic system includes a conveyor device first and second sensors and a diagnostic device. The conveyor device includes an endless chain having a plurality of rollers coupled at regular pitches and each fit into a bush, to circularly move between a first sprocket and a second sprocket. The first and second sensors diagonally are disposed apart from each other on a moving path of the chain, irrespective of an operating direction of the conveyor device, to detect a passage of each of the rollers of the chain. The diagnostic device measures an amount of elongation of the chain based on a first detection signal output from the first sensor and a second detection signal output from the second sensor according to movement of the chain during operation of the conveyor device.

Abstract: A rail installation assist device includes at least control circuitry. The control circuitry is configured to acquire displacement information representing displacement of individual rail brackets and a rail joint from a reference position, the rail brackets that fix guide rails in an elevator shaft, the rail joint that joins the guide rails together; estimate, from the displacement information, a change in the displacement information of the rail brackets and the rail joint when the rail brackets are moved to given target positions; calculate an evaluation value for variation in the displacement information before the change and an evaluation value for variation in the displacement information after the change; and set positions of the rail brackets based on a result of comparison between the evaluation values.

Abstract: An object of the present invention is to provide a method for predicting a risk of developing cancer. DNA samples were prepared from blood and cancer tissues of 2480 cancer patients and analyzed for the nucleotide sequences of exon regions using NGS. As a result, among the cancer patients, 7 patients were confirmed to have D49H mutation or A159D mutation which is a germ cell mutation.

Abstract: According to one embodiment, a diagnostic system includes a conveyor device first and second sensors and a diagnostic device. The conveyor device includes an endless chain having a plurality of rollers coupled at regular pitches and each fit into a bush, to circularly move between a first sprocket and a second sprocket. The first and second sensors diagonally are disposed apart from each other on a moving path of the chain, irrespective of an operating direction of the conveyor device, to detect a passage of each of the rollers of the chain. The diagnostic device measures an amount of elongation of the chain based on a first detection signal output from the first sensor and a second detection signal output from the second sensor according to movement of the chain during operation of the conveyor device.

Abstract: A rail installation assist device includes at least control circuitry. The control circuitry is configured to acquire displacement information representing displacement of individual rail brackets and a rail joint from a reference position, the rail brackets that fix guide rails in an elevator shaft, the rail joint that joins the guide rails together; estimate, from the displacement information, a change in the displacement information of the rail brackets and the rail joint when the rail brackets are moved to given target positions; calculate an evaluation value for variation in the displacement information before the change and an evaluation value for variation in the displacement information after the change; and set positions of the rail brackets based on a result of comparison between the evaluation values.

Abstract: An object of the present invention is to provide a method for predicting a risk of developing cancer. DNA samples were prepared from blood and cancer tissues of 2480 cancer patients and analyzed for the nucleotide sequences of exon regions using NGS. As a result, among the cancer patients, 7 patients were confirmed to have D49H mutation or A159D mutation which is a germ cell mutation.

Abstract: The present disclosure provides a method for molding a pipe body that can inexpensively mold a pipe body having a tapered portion radially outwardly projecting relative to a large-diameter portion. The method for molding a pipe body comprises: molding of a tubular body by bending an unfolded stock so as to wrap a core metal; and removal of the core metal from inside the tubular body. The core metal comprises a first core metal piece for molding a projecting portion of the tapered portion. During the molding of the tubular body, the first core metal piece at least partly abuts on an inner surface of the projecting portion of the tapered portion, and does not abut on an area of the inner surface of the large-diameter portion located in an opposite side of a central axis of the large-diameter portion from the projecting portion.

Abstract: The present disclosure provides a method for molding a pipe body that can inexpensively mold a pipe body having a tapered portion radially outwardly projecting relative to a large-diameter portion. The method for molding a pipe body comprises: molding of a tubular body by bending an unfolded stock so as to wrap a core metal; and removal of the core metal from inside the tubular body. The core metal comprises a first core metal piece for molding a projecting portion of the tapered portion. During the molding of the tubular body, the first core metal piece at least partly abuts on an inner surface of the projecting portion of the tapered portion, and does not abut on an area of the inner surface of the large-diameter portion located in an opposite side of a central axis of the large-diameter portion from the projecting portion.

Abstract: An escalator step includes a tread having a body section on which a plurality of convex sections are arranged in parallel, a riser connected to a rear end portion of the tread and having thereon a plurality of convex sections and a plurality of concave sections formed between the adjacent convex sections, and a shock absorbing cleat provided on a corner at which the riser and tread are connected to each other. The shock absorbing cleat includes a plurality of long convex sections which are arranged in parallel and a plurality of short convex sections which are arranged in parallel between the adjacent long convex sections. The shock absorbing cleat is formed of a polymeric material having a Young's modulus of 1000 MPa or less.

Abstract: An escalator step includes: a tread that includes a body section wherein a plurality of convex sections, which are parallel in a travelling direction, are arranged in a width direction; a riser that is coupled at a rear end portion of the body section of the tread and on which a plurality of convex sections are arranged in a width direction, with troughs being formed between adjacent convex sections; and a shock absorbing cleat located in a notch formed in a corner portion where the riser and the tread are coupled together. On the shock absorbing cleat, a plurality of convex sections, arranged in a width direction and parallel to the travelling direction, rear end surfaces are flush with troughs of the riser, each of the convex sections of the shock absorbing cleat is shifted a half pitch from each of the convex sections of the riser.

Abstract: An escalator step includes: a tread that includes a body section wherein a plurality of convex sections, which are parallel in a travelling direction, are arranged in a width direction; a riser that is coupled at a rear end portion of the body section of the tread and on which a plurality of convex sections are arranged in a width direction, with troughs being formed between adjacent convex sections; and a shock absorbing cleat located in a notch formed in a corner portion where the riser and the tread are coupled together. On the shock absorbing cleat, a plurality of convex sections, arranged in a width direction and parallel to the travelling direction, rear end surfaces are flush with troughs of the riser, each of the convex sections of the shock absorbing cleat is shifted a half pitch from each of the convex sections of the riser.

Abstract: An escalator step includes a tread having a body section on which a plurality of convex sections are arranged in parallel, a riser connected to a rear end portion of the tread and having thereon a plurality of convex sections and a plurality of concave sections formed between the adjacent convex sections, and a shock absorbing cleat provided on a corner at which the riser and tread are connected to each other. The shock absorbing cleat includes a plurality of long convex sections which are arranged in parallel and a plurality of short convex sections which are arranged in parallel between the adjacent long convex sections. The shock absorbing cleat is formed of a polymeric material having a Young's modulus of 1000 MPa or less.

Abstract: A process of producing positive electrode active material particles for a battery, comprising a step of providing a slurry comprising resin particles, a cationic surfactant and/or a polyvinyl alcohol derivative, lithium complex oxide particles, and a polar solvent; removing the polar solvent from the slurry to give a composition; and firing the composition and at the same time, removing the resin particles from the composition, wherein the cationic surfactant is a quaternary ammonium salt, the polyvinyl alcohol derivative is a polyvinyl alcohol into which a quaternary ammonium salt group has been introduced or which has been substituted by a quaternary ammonium salt group, and the resin particles have an average particle size of 0.1 to 20 ?m.

Abstract: A footstep guide rail (3) (rail body 3a) is arranged so that a level H of a horizontal surface is set at the position obtained by adding a designated offset ? to a tangential line L of a drive sprocket (9) and the footstep guide rail (3) is provided, at its one end on an introductory side of the drive sprocket (9), with a curved part (13). At a reference position closest to the drive sprocket (9), the horizontal surface of the footstep guide rail (3) is changed to the curved part (13). Consequently, it is possible to absorb velocity unevenness of one footstep roller approaching the drive sprocket (9).

Abstract: A sintered lithium complex oxide characterized in that the sintered lithium complex oxide is constituted by sintering fine particles of a lithium complex oxide, the peak pore size giving the maximum differential pore volume is 0.80-5.00 ?m, the total pore volume is 0.10-2.00 mL/g, the average particle size is not less than the above-specified peak pore size but not more than 20 ?m, there is a sub-peak giving a differential pore volume not less than 10% of the maximum differential pore volume on the smaller pore size side with respect to the above-specified peak pore size, the pore size corresponding to the sub-peak is more than 0.50 ?m but not more than 2.00 ?m, the BET specific surface area of the sintered lithium complex oxide is 1.0-10.0 m2/g, and the half width of the maximum peak among X-ray diffraction peaks in an X-ray diffraction measurement is 0.12-0.30 deg.

Abstract: A process of producing positive electrode active material particles for a battery, comprising a step of providing a slurry comprising resin particles, a cationic surfactant and/or a polyvinyl alcohol derivative, lithium complex oxide particles, and a polar solvent; removing the polar solvent from the slurry to give a composition; and firing the composition and at the same time, removing the resin particles from the composition, wherein the cationic surfactant is a quaternary ammonium salt, the polyvinyl alcohol derivative is a polyvinyl alcohol into which a quaternary ammonium salt group has been introduced or which has been substituted by a quaternary ammonium salt group, and the resin particles have an average particle size of 0.1 to 20 ?m.

Abstract: The present invention relates to a process for preparing a toner for electrophotography containing a resin binder and a colorant, including the step of preparing fine particles of the resin binder to have a volume-median particle size (D50) of from 0.05 to 3 ?m in an aqueous medium in the presence of a nonionic surfactant within a temperature range of from 10° C. below to 10° C. above a cloud point of the nonionic surfactant; and a toner for electrophotography obtained by the process as defined above, wherein the toner contains 60% by weight or more of a crystalline polyester and has a volume-median particle size (D50) of from 1 to 7 ?m. The toner obtained according to the process of the present invention can be suitably used, for example, in development of a latent image formed in electrophotography, electrostatic recording method, electrostatic printing method, or the like.

Abstract: The present invention relates to a process for producing a resin emulsion which includes the steps of (a) dispersing a resin containing acidic group in a basic aqueous medium at a temperature lower than a softening point of the resin; (b) neutralizing a dispersion obtained in the step (a) at a temperature not lower than a glass transition point of the resin and not higher than the softening point of the resin; and (c) adding an aqueous liquid to the dispersion neutralized in the step (b) at the temperature not lower than the glass transition point of the resin and not higher than the softening point of the resin to emulsify the resin in the aqueous medium. According to the present invention, the resin emulsion suitably usable for production of a toner for electrophotography can be efficiently produced without using an organic solvent and a special apparatus.

Abstract: Provided is a passenger conveyor including a plurality of steps (2) having step rollers (6 and 7), a step chain (8) circulatingly moving in conjunction with each of the plurality of steps (2), guide rails (13a, 13b, 14a and 14b) provided in an intermediate portion of a truss and guiding the step rollers (6 and 7) of each step (2), and an intermediate driving device (12) provided in the intermediate portion of the truss and configured to transmit a driving force to the step chain (8). A step-attitude changing zone (Z) for changing the attitude of each step (2) on a return path side is provided on the traveling path of the steps (2) on the return path side.