Patents by Inventor Yoshiro Iga
Yoshiro Iga has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 5130244Abstract: A stable aqueous thrombin solution containing thrombin and a sugar and an amino acid as a stabilizer is disclosed. According to the present invention, there is provided a stable aqueous thrombin solution.Type: GrantFiled: August 5, 1988Date of Patent: July 14, 1992Assignee: The Green Cross CorporationInventors: Hideo Nishimaki, Kenmi Miyano, Shouju Kameyama, Kazuo Takechi, Yoshiro Iga
-
Patent number: 5116950Abstract: An aqueous solution containing fibrinogen is heated in the presence of at least a sugar, an amino acid and a magnesium salt to thereby inactivate virus(es) possibly contaminating said fibrinogen. According to this process, the inactivation of the contaminating viruses can be achieved while maintaining the activity of the fibrinogen. Thus a highly safe fibrinogen preparation of excellent qualities can be prepared on an industrial scale.Type: GrantFiled: April 21, 1988Date of Patent: May 26, 1992Assignee: Green Cross CorporationInventors: Kenmi Miyano, Kenji Tanaka, Hideo Nishimaki, Yoshiro Iga
-
Patent number: 5053498Abstract: A therapeutic and prophylactic agent for peptic ulcers which contains as an active ingredient a compound of the general formula (I): ##STR1## wherein R.sub.1 represents hydrogen or .dbd.O; R.sub.2 represents hydrogen or --OR.sub.5 ; R.sub.3 represents hydrogen or --OR.sub.5 ; R.sub.4 represents --OR.sub.7 in the case of the absence of double bond; R.sub.5, R.sub.6 and R.sub.7 each represents hydrogen or an organic residue;X represents group (A);.dbd.C.dbd.CH--COR.sub.8 (A)or group (B): ##STR2## wherein R.sub.8 represents alkyl, and R.sub.9 and R.sub.10 each represents hydrogen or an organic residue; with the proviso that when X represents group (A), then R.sub.1 and R.sub.3 both represent hydrogen, R.sub.2 represents --OR.sub.5, R.sub.4 represents OR.sub.7 and the bond between the carbon atom to which X is attached and the carbon atom to which R.sub.4 is attached is a single bond, and when X represents group (B), then R.sub.1 represents .dbd.O, R.sub.2 represents hydrogen, R.sub.3 represents --OR.sub.Type: GrantFiled: October 16, 1989Date of Patent: October 1, 1991Assignee: Green Cross CorporationInventors: Yusei Shiraga, Chikara Fukaya, Toshiaki Akira, Masakazu Iwai, Kazumasa Yokoyama, Mamoru Tabata, Hiroshi Fukui, Shigeo Tanaka, Yoshiro Iga, Tadakazu Suyama, Kanemichi Okano
-
Patent number: 4996050Abstract: A fibrinolytic activity enhancer for signal-chain pro-urokinase comprising plasminogen as an active ingredient is disclosed. The fibrinolytic activity enhancer of the present invention enhances the fibrinolytic activity of single-chain pro-urokinase without causing systemic fibrinolysis. Thus, it is highly useful in the treatment of thrombosis and obstructive diseases.Type: GrantFiled: October 3, 1988Date of Patent: February 26, 1991Assignee: Green Cross CorporationInventors: Minoru Tsukada, Kenji Tanaka, Yoshiro Iga
-
Patent number: 4923815Abstract: An aqueous solution containing thrombin is heated in the presence of at least one stabilizer selected from various sugars to thereby inactivate viruses possibly contaminating said thrombin. According to this process, the inactivation of the contaminating viruses can be achieved while stably maintaining the thrombin. The stabilizing effect of this process can be further enhanced by using an amino acid as a stabilizer in combination with the sugar.Type: GrantFiled: March 25, 1988Date of Patent: May 8, 1990Assignee: Green Cross CorporationInventors: Kenji Tanaka, Kenmi Miyano, Hideo Nishimaki, Yoshiro Iga
-
Patent number: 4888417Abstract: A therapeutic and prophylactic agent for peptic ulcers which contains as an active ingredient a compound of the general formula (I): ##STR1## wherein R.sub.1 represents hydrogen or =O; R.sub.2 represents hydrogen or --OR.sub.5 ; R.sub.3 represents hydrogen or --OR.sub.6 ; R.sub.4 represents --OR.sub.7 in the case of the absence of double bond; R.sub.5, R.sub.6 and R.sub.7 each represents hydrogen or an organic residue;X represents group (A):.dbd.C.dbd.CH--COR.sub.8 (A)or group (B): ##STR2## wherein R.sub.8 represents alkyl, and R.sub.9 and R.sub.10 each represents hydrogen or an organic residue; with the proviso that when X represents group (A), then R.sub.1 and R.sub.3 both represent hydrogen, R.sub.2 represents --OR.sub.5 ; R.sub.4 represents OR.sub.7 and the bond between the carbon atoms to which X is attached and the carbon atom to which R.sub.4 is attached is a single bond, and when X represents group (B), then R.sub.1 represents .dbd.O, R.sub.2 represents hydrogen, R.sub.3 represents --OR.sub.Type: GrantFiled: May 27, 1986Date of Patent: December 19, 1989Assignee: Green Cross CorporationInventors: Yusei Shiraga, Chikara Fukaya, Toshiaki Akira, Masakazu Iwai, Kazumasa Yokoyama, Mamoru Tabata, Hiroshi Fukui, Shigeo Tanaka, Yoshiro Iga, Tadakazu Suyama, Kanemichi Okano
-
Patent number: 4822872Abstract: A method for purifying factor VIII complex comprising: (A) absorbing an impure extract containing factor VIII complex on a water-insoluble carrier, and (B) recovering factor VIII complex in the unadsorbed fractions, wherein said water-insoluble carrier contains as a ligand a group represented by the formula (I) or (II):--(CH.sub.2).sub.n --NH.sub.2 (I) or--(CH.sub.2).sub.n --CHO (II)wherein n is an integer of from 3 to 10.Type: GrantFiled: May 15, 1987Date of Patent: April 18, 1989Assignee: Green Cross CorporationInventors: Syojyu Kameyama, Hideo Nishimaki, Yoshiro Iga, Tadakazu Suyama
-
Patent number: 4732760Abstract: A curative and preventive agent for ulcers of digestive organs comprising as the main constituent an active component having anti-ulcer activity derived from a hot-water, an alcohol or a water-alcohol mixed solution extract of cassia buds.Type: GrantFiled: June 20, 1986Date of Patent: March 22, 1988Assignee: The Green Cross CorporationInventors: Yoshiro Iga, Kanemichi Okano, Toshiaki Akira
-
Patent number: 4446134Abstract: Human blood coagulation factor VIII which may have hepatitis virus activity can be virus-inactivated with keeping at a minimum the damage of the factor VIII by heating its aqueous solution at 50.degree. to 80.degree. C. for 3 to 15 hours in the presence of 10% (W/V) or more of at least one principal stabilizer of neutral amino acids, monosaccharides, oligosaccharides, and sugar alcohols and 10% (W/V) or more of at least one auxiliary stabilizer of salts of hydrocarbon and hydroxyhydrocarbon carboxylic acids having 3 to 10 carbon atoms.Type: GrantFiled: February 19, 1982Date of Patent: May 1, 1984Assignee: The Green Cross CorporationInventors: Ryoichi Naito, Tadakazu Suyama, Yoshiro Iga
-
Patent number: 4093608Abstract: A process for purifying coagulation factor VIII which comprises contacting a plasma or a plasma fraction containing prothrombin complex and coagulation factor VIII (antihemophilic factor A) with diethylaminoethyl-crosslinked dextran to adsorb and remove the prothrombin complex from said plasma or plasma fraction. Coagulation factor VIII thus obtained can be administered to control the bleeding in hemophilia A patients.Type: GrantFiled: April 1, 1977Date of Patent: June 6, 1978Assignee: The Green Cross CorporationInventors: Yoshiro Iga, Masashi Shiga