Abstract: The present invention relates to a process for preparing granules of a hydrophilic vitamin with polyvinylpyrrolidone as binder in a fluidized bed granulator, to the granules of a hydrophilic vitamin obtained by said process, to tablets made with said granules of a hydrophilic vitamin, to mixture of L-ascorbic acid for direct tabletting and tablets made with said mixtures.

Abstract: Disintegrating buccal tablets comprising a physiologically active material and a polyvinyl alcohol/polyethylene glycol graft copolymer are disclosed along with methods of making the same.

Abstract: [Problem] To provide pharmaceutical preparations where the dissolution of an amine drug can be effectively controlled. [Resolution Means] Slow-release granules formed by providing a coating layer containing polyvinyl acetate and surfactant on drug-containing particles comprising an amine drug and a water-soluble binder coated onto the surface of a core material; together with a method for the production of slow-release granules which includes (i) a stage in which a liquid comprising an amine drug and a water-soluble binder dissolved or dispersed in an aqueous solvent is sprayed onto the surface of a core material and dried to form a drug layer, and (ii) a stage in which an aqueous coating liquid containing polyvinyl acetate and surfactant is sprayed onto the drug-containing particles obtained in stage (i) and dried to form a coating layer.

Abstract: There is provide a novel process for producing a coated preparation composed of a hydrophilic core material coated with a coat material selected from hydrophobic hot-melt lipid to control dissolution of the core material in water and to prevent blocking during the production thereof. In this process, the melted coat material is added dropwise to the core material with fluidizing the core material to form at least one coating layer about the core material in the presence of, or by addition of &bgr;-form seed crystals of the coat material. Further, there is provided a water-soluble vitamin preparation having an improved flavor which contains a coated water-soluble vitamin having an unpleasant flavor produced by the novel process.

Abstract: There is provide a novel process for producing a coated preparation composed of a hydrophilic core material coated with a coat material selected from hydrophobic hot-melt lipid to control dissolution of the core material in water and to prevent blocking during the production thereof. In this process, the melted coat material is added dropwise to the core material with fluidizing the core material to form at least one coating layer about the core material in the presence of, or by addition of &bgr;-form seed crystals of the coat material. Further, there is provided a water-soluble vitamin preparation having an improved flavor which contains a coated water-soluble vitamin having an unpleasant flavor produced by the novel process.

Abstract: There is provide a process for producing a coated preparation composed of a hydrophilic core material coated with a coat material selected from hydrophobic hot-melt lipid to control dissolution of the core material in water and to prevent blocking during the production thereof. In this process, the melted coat material is added dropwise to the core material with fluidizing the core material to form at least one coating layer about the core material in the presence of, or by addition of &bgr;-form seed crystals of the coat material. Further, there is provided a water-soluble vitamin preparation having an improved flavor which contains a coated water-soluble vitamin having an unpleasant flavor produced by the novel process.

Abstract: A method of producing .beta.-form thiamine hydrochloride crystals which comprises moistening .alpha.-form thiamine hydrochloride crystals in the presence of .beta.-form thiamine hydrochloride crystals as seed crystals and stirring the mixture and a method of producing pharmaceutical preparations containing .beta.-form thiamine hydrochloride crystals which comprises moistening .alpha.-form thiamine hydrochloride crystals, together with a binder, with water in the presence of .beta.-form thiamine hydrochloride crystals as seed crystals and stirring the mixture..beta.-Form thiamine hydrochloride crystals which are stable and resistant to caking and pharmaceutical preparations containing the same can be produced in a simple and easy manner.

Abstract: A composition which consists of a compound belonging to the Vitamin B group and having a solubility in water at 20.degree. C. of not more than 5%, and mannitol, is stable in itself and undergoes less influence under ambient humidity conditions.Its good flowability is retained during storage, only with very small changes, if any.

Abstract: The bath preparation of the present invention comprises an ascorbic acid compound and at least one reducing agent selected from the group consisting of water-soluble thiosulfate, water-soluble dithionite, L-cysteine hydrochloride, glutathione and gallic acid ester.