Patents by Inventor Yoshiyasu Shitori
Yoshiyasu Shitori has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5158886Abstract: A hybridoma producing a monoclonal antibody specific for free N-acetylneuraminic acid or beta glycoconjugates thereof, is herein disclosed. The hybridoma can be generated by fusing (i) B cells of lymphocytes obtained by immunizing an animal with an N-acetylneuraminic acid or a beta-glycoconjugate thereof, and (ii) myeloma cells.Type: GrantFiled: November 8, 1988Date of Patent: October 27, 1992Assignee: MECT CorporationInventors: Atsushi Kawamura, Isao Suda, Kinji Takada, Masayoshi Ito, Yoshiyasu Shitori
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Patent number: 5141864Abstract: A hybridoma capable of producing a monoclonal antibody specific to a sialic acid containing glycolipid carrying N-acetylneuraminic acid residue having alpha 2.fwdarw.3 linkage is herein disclosed. The hybridoma can be generated by fusing (i) B cells or lymphocytes obtained by immunizing an animal with a sialic acid containing glycolipid carrying N-acetylneuraminic acid residue having alpha 2.fwdarw.3 linkage and (ii) myeloma cells. The monoclonal antibody produced by the hybridoma can be used for purifying gangliosides, for treating patients suffering from melanoma and for diagnosing sera.Type: GrantFiled: November 14, 1988Date of Patent: August 25, 1992Assignee: Mect CorporationInventors: Yoshitaka Nagai, Hideki Yamamoto, Kinji Takada, Ito, Yoshiyasu Shitori
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Patent number: 5126330Abstract: The present invention relates to a sodium salt of sialosyl cholesterol. The present compound has an excellent high water solubility, and therefore the compound is very useful as a medicine to be used for treating various diseases derived from lesions of peripheral or central nerves.Type: GrantFiled: February 1, 1991Date of Patent: June 30, 1992Assignee: Mect CorporationInventors: Haruo Ogura, Kimio Furuhata, Shingo Sato, Masayoshi Ito, Yoshiyasu Shitori, Yoshitaka Nagai
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Patent number: 5101026Abstract: The present invention relates to ganglioside related compounds having, for example, the following formula: ##STR1## where R.sub.1 represents H or COCH.sub.3 (hereinafter abbreviated to "AC"); R.sub.2 represents H or CH.sub.3 ; and R.sub.3 represents --OH, ##STR2## These ganglioside related compounds are useful as membrane receptors, tumor markers, cell growth controlling substances, etc., and useful for immunotherapy for cancer, etc.Type: GrantFiled: August 6, 1987Date of Patent: March 31, 1992Assignee: MECT CorporationInventors: Tomoya Ogawa, Mamoru Sugimoto, Masaaki Numata, Masayoshi Ito, Yoshiyasu Shitori, Shigeki Nunomura
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Patent number: 5057605Abstract: Sialocylglycerolipids represented by the following general formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or a group CH.sub.3 CO--; R.sup.2 represents an alkali metal, a hydrogen atom or a lower alkyl group; R.sup.3 represents a hydrogen atom or a group C.sub.n H.sub.2n+1 -- (n is an integer ranging from 1 to 30); and R.sup.4 represents a group C.sub.m H.sub.2n+1 -- (m is an integer ranging from 1 to 30) are herein disclosed. They are prepared by treating a corresponding compound in an alkaline aqueous solvent. The method makes it possible to provide these compounds in a high yield by a simple processes.Type: GrantFiled: November 10, 1988Date of Patent: October 15, 1991Assignee: Mect CorporationInventors: Shoji Yoshimura, Yuzi Matsuzaki, Mamoru Sugimoto, Masayoshi Ito, Yoshiyasu Shitori, Tomoya Ogawa
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Patent number: 5023239Abstract: The present invention relates to a sodium salt of sialosyl cholesterol. The present compound has an excellent high water solubility, and therefore the compound is very useful as a medicine to be used for curing various diseases derived from lesions of peripheral or central nerves.Type: GrantFiled: January 7, 1988Date of Patent: June 11, 1991Assignee: MECT CorporationInventors: Haruo Ogura, Kimio Furuhata, Shingo Sato, Masayoshi Ito, Yoshiyasu Shitori, Yoshitaka Nagai
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Patent number: 5015631Abstract: A repairing agent for cells and tissues is disclosed, which agent comprises, as an active ingredient, a compound of the general formula: ##STR1## wherein Z represents lithium, potassium, sodium, ammonium or an organic ammonium when n is 1, and Z represents calcium, barium or magnesium when n is 2.Type: GrantFiled: June 24, 1988Date of Patent: May 14, 1991Assignee: MECT CorporationInventors: Sadanori Ogasawara, Kenji Abiko, Masayoshi Ito, Yoshiyasu Shitori
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Patent number: 4990604Abstract: Method for the production of asialoganglioside related compounds of the formula (I). ##STR1## wherein R.sup.1 is hydrogen or benzoyl, R.sup.2 is hydrogen or acetyl, R.sup.3 is hydrogen, acetyl, .beta.-D-galactopyranosyl or 2,3,4,6-tetra-O-acetyl-.beta.-D-galactopyranosyl, R.sup.7 and R.sup.8 are individually alkyl having 1 to 30 carbon atoms and Ac is acetyl.Type: GrantFiled: February 24, 1986Date of Patent: February 5, 1991Assignees: Rikagaku Kenkyusho, Kanto Ishi Pharmaceutical Co., Ltd., Teikoku Chemical Industry Co., Ltd.Inventors: Tomoya Ogawa, Mamoru Sugimoto, Yoshiyasu Shitori, Toshio Horisaki, Tadami Shinuchi
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Patent number: 4990603Abstract: The present invention relates to sialic acid derivatives. According to the present invention, there is provided sialic acid derivatives having the general formula (I): ##STR1## wherein, R.sup.1 represents hydrogen, an acetyl group, a trityl group, ##STR2## (R.sup.5 represents hydrogen or an acetyl group and R.sup.6 represents hydrogen, sodium or a methyl group).R.sup.2 represents hydrogen or an acetyl group,one of R.sup.3 and R.sup.4 represents ##STR3## (R.sup.7 represents a hydrogen atom or an acetyl group, R.sup.8 represents a hydrogen atom, an acetyl group or a benzyl group, R.sup.9 represents a hydrogen atom, an acetyl group, a benzyl group or ##STR4## wherein R.sup.10 represents a hydrogen atom or a benzoyl group), while the other represents --COOR.sup.11 wherein R.sup.11 represents hydrogen, sodium, or a methyl group.Type: GrantFiled: June 30, 1987Date of Patent: February 5, 1991Assignee: Mect CorporationInventors: Tomoya Ogawa, Mamoru Sugimoto, Masaaki Numata, Shoji Yoshimura, Masayoshi Ito, Yoshiyasu Shitori
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Patent number: 4968786Abstract: Novel sialic acid derivatives and galactose derivatives which are useful intermediate for the synthesis of gangliosides. Methods for the production of the sialic acid and galactose derivatives. Methods for the production of ganglioside GM.sub.3.Type: GrantFiled: June 27, 1985Date of Patent: November 6, 1990Assignees: Rikagaku Kenkyusho, MECT CorporationInventors: Tomoya Ogawa, Mamoru Sugimoto, Yoshiyasu Shitori, Masayoshi Ito
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Patent number: 4950750Abstract: The present invention provides ganglioside-related compounds expressed by the following formula: ##STR1## (wherein R.sub.1 denotes a hydrogen atom or SiR.sub.3 R.sub.4 R.sub.5 (wherein R.sub.3 and R.sub.4 each denotes a methyl or phenyl group, and R.sub.5 denotes a tertiary butyl or dimethylphenylmethyl group), and R.sub.2 denotes a hydrogen atom, a trityl group, or ##STR2## (wherein M denotes an alkali metal atom)) and methods of producing the same. These ganglioside-related compounds are useful as markers for the early detection of cancer and in the immunotherapy for cancer.Type: GrantFiled: October 19, 1987Date of Patent: August 21, 1990Assignee: Mect CorporationInventors: Tomoya Ogawa, Masaaki Numata, Mamoru Sugimoto, Shohei Shibayama, Shoji Yoshimura, Masayoshi Ito, Yoshiyasu Shitori
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Patent number: 4918177Abstract: A sialic acid derivative having an active carbonyl group represented by the formula [I]: ##STR1## wherein R.sup.1 represents hydrogen or acetyl group; R.sup.2 represents hydrogen, a metal or a lower alkyl group; R.sup.3 represents hydrogen, hydroxyl group, or a residue removed hydrogen from an alcohol portion of an active ester; Ac represents acetyl group; and n is 1 to 20, respectively. This sialic acid derivative [I] can be utilized as a starting material for various complex having a sialic acid in the molecule since it has an active carbonyl group in the molecules so that it shows high reactivity.Type: GrantFiled: December 21, 1987Date of Patent: April 17, 1990Assignee: Mect CorporationInventors: Shoji Yoshimura, Shohei Shibayama, Masaaki Numata, Masayoshi Ito, Yoshiyasu Shitori, Tomoya Ogawa
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Patent number: 4914195Abstract: A new process for preparing halides of N-acetylneuraminic acids useful as an intermediate in preparing new N-acetylneuraminic acid derivatives having an excellent immunological activity is provided, which process comprises simultaneously acetylating and halogenating an esterified N-acetylneuraminic acid with the aid of an acetyl halide, and according to the process, the halides may be obtained in high yield of about 90%.Type: GrantFiled: November 26, 1984Date of Patent: April 3, 1990Assignee: MECT CorporationInventors: Haruo Ogura, Kimio Furuhata, Yoshiyasu Shitori, Masayoshi Ito
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Patent number: 4880572Abstract: Novel unnatural ceramide related compounds, for instance, (2S, 3S)-2-tetracosanamido-octadecane-1,3-diol are herein provided, which are useful as intermediates in preparing ceramide moieties employed in the preparation of glycolipids and gangliosides known as tumor markers or molecular markers and which are prepared by, for instance, subjecting a chiral compound represented by the following formula: ##STR1## to deacetal treatment.Type: GrantFiled: May 26, 1988Date of Patent: November 14, 1989Assignee: MECT CorporationInventors: Shuji Fujita, Shoji Yoshimura, Masayoshi Ito, Yoshiyasu Shitori, Tomoya Ogawa
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Patent number: 4797477Abstract: The present invention relates to a new process for preparing 3-O-(sodium(5-acetamide-3,5-dideoxy-alpha-D-glycero-D-galacto-2-noneuro pyranosyl)onate-1,2-di-O-tetradecyl-Sn-glycerol (3) consisting essentially of hydrolyzing a 3-O-(C.sub.1-5 alkyl(5-acetamide-4,7,8,9-tetra-O-acetyl-3,5-di-deoxy-alpha-D-glycero-D-ga lacto-2-noneuropyranosyl)onate)-1,2-di-O-tetradecyl-Sn-glycerol (1) in a single step, in an aqueous lower aliphatic alcohol solution of an alkali metal hydroxide.Type: GrantFiled: August 11, 1987Date of Patent: January 10, 1989Assignee: Mect CorporationInventors: Shoji Yoshimura, Yoichiro Tani, Youzi Matsuzaki, Masayoshi Ito, Yoshiyasu Shitori, Tomoya Ogawa
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Patent number: 4788200Abstract: A medicament for curing arteriosclerosis which comprises pyrimido [2,1-b] benzothiazole derivative.Type: GrantFiled: August 27, 1987Date of Patent: November 29, 1988Assignee: MECT CorporationInventors: Ryuji Niwa, Nobuya Katagiri, Tetsuzo Kato, Yoshiyasu Shitori, Jiro Horiuchi
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Patent number: 4774326Abstract: This invention provides a novel process for preparing a compound represented by the formula ##STR1## In accordance with this invention, the compound is prepared by reacting a compound represented by the formula ##STR2## with glycolic acid in the presence of dicyclohexylcarbodiimide.Type: GrantFiled: October 10, 1986Date of Patent: September 27, 1988Assignee: Mect CorporationInventors: Shohei Shibayama, Shoji Yoshimura, Masayoshi Ito, Yoshiyasu Shitori, Tomoya Ogawa
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Patent number: 4774327Abstract: This invention provides a novel compound having the following formula: ##STR1## This compound is a useful intermediate for the preparation of N-glycolylneuraminic acid: ##STR2##Type: GrantFiled: October 10, 1986Date of Patent: September 27, 1988Assignee: Mect CorporationInventors: Haruo Ogura, Kimio Furuhata, Masayoshi Ito, Yoshiyasu Shitori
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Patent number: 4751290Abstract: This invention provides a novel compound having a formula such as ##STR1## This invention also provides a process for preparing such a compound.Type: GrantFiled: June 6, 1986Date of Patent: June 14, 1988Assignees: Rikagaku Kenkyusho, Mect CorporationInventors: Tomoya Ogawa, Mamoru Sugimoto, Masaaki Numata, Yoshiyasu Shitori, Masayoshi Ito
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Patent number: RE34091Abstract: A sialic acid derivative having an active carbonyl group represented by the formula [I]: ##STR1## wherein R.sup.1 represents hydrogen or acetyl group; R.sup.2 represents hydrogen, a metal or a lower alkyl group; R.sup.3 represents hydrogen, hydroxyl gorup, or a residue removed hydrogen from an alcohol portion of an active ester; Ac represents acetyl group; and n is 1 to 20, respectively. This sialic acid derivative [I] can be utilized as a starting material for various complex having a sialic acid in the molecule since it has an active carbonyl group in the molecules so that it shows high reactivity.Type: GrantFiled: October 21, 1991Date of Patent: October 6, 1992Assignee: MECT CorporationInventors: Shoji Yoshimura, Shohei Shibayama, Masaaki Numata, Masayoshi Ito, Yoshiyasu Shitori, Tomoya Ogawa