Abstract: Provided are: a coloring cellulose microparticle enabling false positive to be significantly reduced while maintaining a high detection sensitivity; and an immunochromatographic diagnostic kit using the same.

Abstract: Provided are: a coloring cellulose microparticle enabling false positive to be significantly reduced while maintaining a high detection sensitivity; and an immunochromatographic diagnostic kit using the same. The present invention provides: a coloring cellulose microparticle characterized in that an average particle diameter is 60-900 nm, a coloring intensity is 1.0-10.0, and a hydrophilic layer is provided on the surface of microparticle, and a carboxyl group is introduced onto the surface of the microparticle with a spacer therebetween; a structure in which a ligand is covalently bonded to the carboxyl group of said coloring cellulose microparticle; and an immunochromatographic diagnostic kit including said structure.

Abstract: The present invention provides organic colored microparticles used in an immunochromatography diagnostic kit, the microparticles having good background and test result reproducibility and sufficient detection sensitivity. These organic colored microparticles are characterized in that the average particle diameter is 100 to 650 nm; coloration intensity is 1.0 to 10.0; when a total of 100,000 particles are detected within a particle diameter range of 400 to 12000 nm, the percentage of coarse particles having a particle diameter of 700 nm or greater is 5% or less; and the sphericity represented by the major axis (L)/minor axis (D) is 1.0 to 2.5.

Abstract: Provided is an immunochromatographic diagnostic kit which renders prompt diagnosis possible, has high analysis sensitivity, and gives test results with excellent reproducibility. The immunochromatographic diagnostic kit includes: a conjugate pad that contains a conjugate containing chromogenic particles which have an average particle diameter of 100-1,000 nm and attain a color intensity of 1.0-10.0, 10-90 wt % of the particles being derived from cellulose and 90-10 wt % of the particles being derived from a colorant; and a sample pad for an in vitro diagnostic reagent, the sample pad being constituted of nonwoven fabric that has a basis weight of 10-150 g/m2 and a thickness of 0.07-1.00 mm and comprises regenerated cellulosic fibers.

Abstract: Provided are an immunochromatography kit that is highly sensitive and capable of multicoloration, and organic colored microparticles that are ideal as an element of the immunochromatography kit. Organic colored microparticles having an average grain size between 10 and 1,000 nm and a color intensity between 1.0 and 5.0 are prepared using cellulose as the starting material. When the organic colored microparticles are used as a label in an immunochromatography kit, the immunochromatography kit is of a high sensitivity than conventional technology. The immunochromatography kit is also capable of multicoloration and is useful for rapid diagnosis.

Abstract: An object of the present invention is to provide a hydrophilic cellulose derivative fine particle having a small particle size, a dispersion liquid thereof and a dispersion body thereof; and provide a diagnostic reagent composed of the hydrophilic particle, which is excellent in storage stability and does not require excess components, such as an emulsifier or surfactant. The cellulose derivative fine particle of the present invention is a cellulose derivative fine particle comprising a cellulose derivative with a part of hydroxyl groups of cellulose being substituted with a substituent, wherein the average particle diameter is from 9 to 1,000 nm; and the diagnostic reagent of the present invention is a diagnostic reagent obtained by loading a substance differentially interacting with a test object substance on the above-described cellulose derivative fine particle.

Abstract: Provided is an immunochromatographic diagnostic kit which renders prompt diagnosis possible, has high analysis sensitivity, and gives test results with excellent reproducibility. The immunochromatographic diagnostic kit includes: a conjugate pad that contains a conjugate containing chromogenic particles which have an average particle diameter of 100-1,000 nm and attain a color intensity of 1.0-10.0, 10-90 wt % of the particles being derived from cellulose and 90-10 wt % of the particles being derived from a colorant; and a sample pad for an in vitro diagnostic reagent, the sample pad being constituted of nonwoven fabric that has a basis weight of 10-150 g/m2 and a thickness of 0.07-1.00 mm and comprises regenerated cellulosic fibers.

Abstract: An object of the present invention is to provide a hydrophilic cellulose derivative fine particle having a small particle size, a dispersion liquid thereof and a dispersion body thereof; and provide a diagnostic reagent composed of the hydrophilic particle, which is excellent in storage stability and does not require excess components, such as an emulsifier or surfactant. The cellulose derivative fine particle of the present invention is a cellulose derivative fine particle comprising a cellulose derivative with a part of hydroxyl groups of cellulose being substituted with a substituent, wherein the average particle diameter is from 9 to 1,000 nm; and the diagnostic reagent of the present invention is a diagnostic reagent obtained by loading a substance differentially interacting with a test object substance on the above-described cellulose derivative fine particle.

Abstract: An object of the present invention is to provide a hydrophilic cellulose derivative fine particle having a small particle size, a dispersion liquid thereof and a dispersion body thereof; and provide a diagnostic reagent composed of the hydrophilic particle, which is excellent in storage stability and does not require excess components, such as an emulsifier or surfactant. The cellulose derivative fine particle of the present invention is a cellulose derivative fine particle comprising a cellulose derivative with a part of hydroxyl groups of cellulose being substituted with a substituent, wherein the average particle diameter is from 9 to 1,000 nm; and the diagnostic reagent of the present invention is a diagnostic reagent obtained by loading a substance differentially interacting with a test object substance on the above-described cellulose derivative fine particle.

Abstract: Provided are an immunochromatography kit that is highly sensitive and capable of multicoloration, and organic colored microparticles that are ideal as an element of the immunochromatography kit. Organic colored microparticles having an average grain size between 10 and 1,000 nm and a color intensity between 1.0 and 5.0 are prepared using cellulose as the starting material. When the organic colored microparticles are used as a label in an immunochromatography kit, the immunochromatography kit is of a high sensitivity than conventional technology. The immunochromatography kit is also capable of multicoloration and is useful for rapid diagnosis.

Abstract: An object of the present invention is to provide cellulose fine particles having a small particle diameter and a high average polymerization degree, and a liquid dispersion or a solid dispersion thereof. The inventive cellulose fine particles have an average particle diameter of 9 to 400 nm and an average polymerization degree (DP) of cellulose of 150 to 3,000.

Abstract: An object of the present invention is to provide a hydrophilic cellulose derivative fine particle having a small particle size, a dispersion liquid thereof and a dispersion body thereof; and provide a diagnostic reagent composed of the hydrophilic particle, which is excellent in storage stability and does not require excess components, such as an emulsifier or surfactant. The cellulose derivative fine particle of the present invention is a cellulose derivative fine particle comprising a cellulose derivative with a part of hydroxyl groups of cellulose being substituted with a substituent, wherein the average particle diameter is from 9 to 1,000 nm; and the diagnostic reagent of the present invention is a diagnostic reagent obtained by loading a substance differentially interacting with a test object substance on the above-described cellulose derivative fine particle.

Abstract: An object of the present invention is to provide cellulose fine particles having a small particle diameter and a high average polymerization degree, and a liquid dispersion or a solid dispersion thereof. The inventive cellulose fine particles have an average particle diameter of 9 to 400 nm and an average polymerization degree (DP) of cellulose of 150 to 3,000.