Patents by Inventor Yotam Levin
Yotam Levin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240165382Abstract: A microneedle structure has one or more microneedles (104) projecting from the major surface (102) of a substrate (100). The microneedle has a penetrating tip (106) formed at an intersection between upright surfaces (108) and an inclined surface (110) corresponding to a (1 1 1) crystallographic plane. The microneedle has a first portion bounded by a continuation of the upright surfaces (108) and inclined surface (110), and a second portion bounded by a continuation of the upright surfaces and a slicing plane (112) extending from an edge (114) of inclined surface (110) towards major surface (102) of the substrate. A width W of inclined surface (110) increases monotonically from penetrating tip (106) to edge (114).Type: ApplicationFiled: January 31, 2024Publication date: May 23, 2024Inventors: Gal ADMATI, Yotam LEVIN, Yoav HAMISHA
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Patent number: 11936669Abstract: Unauthorized use of user credentials in a network is detected. Data indicative of text strings being used to access resources in the network is accessed. Regex models are determined for the text strings. Troupings of the regex models are determined based on an optimization of a cumulative weighted function. A regex model having a cumulative weighted function that exceeds a predetermined threshold is identified. An alert is generated when the cumulative weighted function for the identified regex model exceeds the predetermined threshold.Type: GrantFiled: October 4, 2022Date of Patent: March 19, 2024Assignee: MICROSOFT TECHNOLOGY LICENSING, LLCInventors: Andrey Karpovsky, Tomer Rotstein, Fady Nasereldeen, Naama Kraus, Roy Levin, Yotam Livny
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Publication number: 20230330404Abstract: A microneedle structure has one or more microneedles (104) projecting from the major surface (102) of a substrate (100). The microneedle has a penetrating tip (106) formed at an intersection between upright surfaces (108) and an inclined surface (110) corresponding to a (1 1 1) crystallographic plane. The microneedle has an expanding portion bounded by a continuation of the upright surfaces (108) and inclined surface (110), and a constant cross-section portion bounded by a continuation of the upright surfaces and a slicing plane (112) extending from an edge (114) of inclined surface (110) towards, and perpendicular to, major surface (102) of the substrate. A width W of inclined surface (110) increases monotonically from penetrating tip (106) to edge (114).Type: ApplicationFiled: June 25, 2023Publication date: October 19, 2023Inventors: Gal ADMATI, Yotam LEVIN, Yoav HAMISHA
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Patent number: 11717660Abstract: A microneedle structure has one or more microneedles (104) projecting from the major surface (102) of a substrate (100). The microneedle has a penetrating tip (106) formed at an intersection between upright surfaces (108) and an inclined surface (110) corresponding to a (1 1 1) crystallographic plane. The microneedle has an expanding portion bounded by a continuation of the upright surfaces (108) and inclined surface (110), and a constant cross-section portion bounded by a continuation of the upright surfaces and a slicing plane (112) extending from an edge (114) of inclined surface (110) towards, and perpendicular to, major surface (102) of the substrate. A width W of inclined surface (110) increases monotonically from penetrating tip (106) to edge (114).Type: GrantFiled: July 29, 2021Date of Patent: August 8, 2023Assignee: NANOPASS TECHNOLOGIES LTD.Inventors: Gal Admati, Yotam Levin, Yoav Hamisha
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Publication number: 20230144090Abstract: An injection configuration (10) for connection to a male Luer connector (100) includes a hub (12) having an internal conical taper (14) in fluid interconnection with a hollow needle (16). The internal conical taper has a convergence angle of 6% and a length L of 7.5-10.5 millimeters, and presents an entrance aperture diameter D of between 4.365 and 4.595 millimeters.Type: ApplicationFiled: November 8, 2021Publication date: May 11, 2023Inventors: Yoav HAMISHA, Gal ADMATI, Yotam LEVIN
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Publication number: 20230035272Abstract: A microneedle structure has one or more microneedles (104) projecting from the major surface (102) of a substrate (100). The microneedle has a penetrating tip (106) formed at an intersection between upright surfaces (108) and an inclined surface (110) corresponding to a (1 1 1) crystallographic plane. The microneedle has an expanding portion bounded by a continuation of the upright surfaces (108) and inclined surface (110), and a constant cross-section portion bounded by a continuation of the upright surfaces and a slicing plane (112) extending from an edge (114) of inclined surface (110) towards, and perpendicular to, major surface (102) of the substrate. A width W of inclined surface (110) increases monotonically from penetrating tip (106) to edge (114).Type: ApplicationFiled: July 29, 2021Publication date: February 2, 2023Inventors: Gal ADMATI, Yotam LEVIN, Yoav HAMISHA
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Patent number: 11291818Abstract: A microneedle for intradermal injection or diagnostics, constructed as a protrusion above a substrate and whose shape is defined by a pair of vertical side surfaces, configured to be symmetrical about a vertical plane of symmetry and to meet along a vertical leading edge, and by an inclined surface, intersecting the side surfaces, the microneedle also including a vertical bore, located centrally between the two side surfaces and substantially near the leading edge, wherein each of the side surfaces is divided, sequentially along the front-to-back direction, into at least two contiguous planar segments, forming pairs of corresponding segments along the respective side surfaces; each pair of corresponding segments mutually form an acute angle, the angle being between 40 and 70 degrees for the pair of segments adjacent the leading edge and less than 35 degrees for the pair of segments farthest from the leading edge and wherein the leading edge is formed so that its profile includes an arc, joined to the side suType: GrantFiled: April 1, 2020Date of Patent: April 5, 2022Assignee: NANOPASS TECHNOLOGIES LTD.Inventors: Gal Admati, Yoav Hamisha, Yotam Levin
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Publication number: 20210308439Abstract: A microneedle for intradermal injection or diagnostics, constructed as a protrusion above a substrate and whose shape is defined by a pair of vertical side surfaces, configured to be symmetrical about a vertical plane of symmetry and to meet along a vertical leading edge, and by an inclined surface, intersecting the side surfaces, the microneedle also including a vertical bore, located centrally between the two side surfaces and substantially near the leading edge, wherein each of the side surfaces is divided, sequentially along the front-to-back direction, into at least two contiguous planar segments, forming pairs of corresponding segments along the respective side surfaces; each pair of corresponding segments mutually form an acute angle, the angle being between 40 and 70 degrees for the pair of segments adjacent the leading edge and less than 35 degrees for the pair of segments farthest from the leading edge and wherein the leading edge is formed so that its profile includes an arc, joined to the side suType: ApplicationFiled: April 1, 2020Publication date: October 7, 2021Inventors: Gal Admati, Yoav Hamisha, Yotam Levin
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Patent number: 10828429Abstract: A device for delivering a fluid into a biological tissue includes hollow microneedles (10) projecting from a surface (12) of a substrate (14), and a guide element (18) spaced from the substrate. The guide element provides a tissue-contact surface (20) that defines a tissue contact plane oblique to the surface (12) of the substrate (14).Type: GrantFiled: October 27, 2016Date of Patent: November 10, 2020Assignee: NanoPass Technologies Ltd.Inventors: Gal Admati, Yotam Levin
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Publication number: 20170266394Abstract: A device for delivering a fluid into a biological tissue includes hollow microneedles (10) projecting from a surface (12) of a substrate (14), and a guide element (18) spaced from the substrate. The guide element provides a tissue-contact surface (20) that defines a tissue contact plane oblique to the surface (12) of the substrate (14).Type: ApplicationFiled: October 27, 2016Publication date: September 21, 2017Applicant: NanoPass Technologies Ltd.Inventors: Gal ADMATI, Yotam LEVIN
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Publication number: 20150038911Abstract: An adapter (50) for achieving intradennal dosed delivery of a liquid by use of a dosed drug delivery device including a reservoir having a pierceable septum, the adapter having a connector including an attachment configuration (22) for sliding a recess of the adapter onto a projection of the dosed drug delivery device and a hollow needle (25) deployed for piercing the septum. At least one microneedle (10) projects from the connector. A flow path arrangement (28) interconnects the needle and the hollow microneedle(s). The recess is shaped to restrict the microneedle(s) to only a finite number of rotational orientations relative to the axis of the device. The connector and/or the needle is adapted for application of a sealant to prevent leakage of the liquid.Type: ApplicationFiled: January 24, 2013Publication date: February 5, 2015Applicant: NANOPASS TECHNOLOGIES LTDInventors: Yotam Levin, Yehoshua Yeshurun, Nadav Agian, Barak Panga, Yoel sefi, Gal Admati
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Publication number: 20140350514Abstract: Methods are disclosed for delivering a substance to the skin of a human subject. The methods include, obtaining a substance, such as hormones, for example, Insulin; and delivering the substance into an intradermal space within the skin of the human subject through a plurality of microneedles. The microneedles are of a height of approximately 400 micrometers to approximately 750 micrometers.Type: ApplicationFiled: May 22, 2013Publication date: November 27, 2014Applicant: NanoPass Technologies Ltd.Inventor: Yotam LEVIN
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Publication number: 20130110043Abstract: A microneedle intradermal drug delivery device with auto-disable functionality includes a syringe (12) having a plunger (14) displaceable along a barrel (16) and a microneedle adapter (20) with hollow microneedle(s) (22). The microneedle adapter (20) and the syringe (12) are configured for irreversible engagement such that, after attachment of the microneedle adapter (20) to the syringe (12), the microneedle adapter (20) is resistant to non-destructive manual removal from the syringe (12). Also provided are a self-locking plunger configuration (54, 56, 58) and a sliding safety shield (62).Type: ApplicationFiled: October 26, 2012Publication date: May 2, 2013Applicant: NanoPass Technologies Ltd.Inventor: Yotam Levin
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Publication number: 20110282298Abstract: An injection system applicable to off-the-shelf syringes having a microneedle hub may reduce dead space and isolate the drug fluid from the microneedle chip to avoid compatibility issues. An insert may be disposed inside a male luer fitting and extend so that it is also disposed inside the female luer fitting using an insert. A septum may isolate the drug fluid from the microneedle chip in the hub prior to activation and the septum may, after activation, seal the triangular space in the hub to prevent leakage of fluid back to the syringe.Type: ApplicationFiled: December 9, 2009Publication date: November 17, 2011Inventors: Nadav Agian, Yonni Shem-Tov, Barak Panga, Yoel Sefi, Yotam Levin
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Publication number: 20110238038Abstract: An intradermal mini-needle interface has a penetration limiter providing a skin contact edge and a hollow hypodermic needle having a beveled penetrating portion protruding forward beyond the skin contact edge by no more than 3 mm. At least one skin contact surface defines a skin contact plane parallel to, or at a shallow angle to, the needle axis. The skin contact plane intersects the skin contact edge substantially at a base of the penetrating portion. Preferably, the penetration limiter is asymmetric under rotation about the needle axis.Type: ApplicationFiled: December 3, 2009Publication date: September 29, 2011Applicant: Nanopass Technologies Ltd.Inventors: Yoel Sefi, Yotam Levin, Yehoshua Yeshurun, Nadav Agian
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Patent number: 8007466Abstract: A system and method for delivering fluid into a flexible biological barrier employs a microneedle structure wherein a final position of microneedles (12) inserted into the biological barrier (14) is generally sideways projecting from the delivery configuration instead of the conventional downwards projecting arrangement. The microneedles (12) project from a relief surface (16) which is distinct from a primary biological-barrier contact region (18, 26) of the delivery configuration, and is typically angled upwards away from the biological barrier. During insertion, the contact region (18, 26) is brought into contact with the biological barrier (14) and moved parallel to the surface of the flexible biological barrier so as to generate a boundary (20) between a stretched portion (22) and a non-stretched portion (24) of the barrier.Type: GrantFiled: May 19, 2005Date of Patent: August 30, 2011Assignee: Nanopass Technologies Ltd.Inventors: Yehoshua Yeshurun, Meir Hefetz, Yoel Sefi, Yotam Levin, Gilad Lavi
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Patent number: 7998119Abstract: A system and method for delivering fluid into a flexible biological barrier employs a microneedle structure wherein a final position of microneedles inserted into the biological barrier is generally sideways projecting from the delivery configuration instead of the conventional downwards projecting arrangement. The microneedles project from a relief surface which is distinct from a primary biological-barrier contact region of the delivery configuration, and is typically angled upwards away from the biological barrier. During insertion, the contact region is brought into contact with the biological barrier and moved parallel to the surface of the flexible biological barrier so as to generate a boundary between a stretched portion and a non-stretched portion of the barrier.Type: GrantFiled: May 23, 2005Date of Patent: August 16, 2011Assignee: Nano Pass Technologies Ltd.Inventors: Yehoshua Yeshurun, Meir Hefetz, Yoel Sefi, Yotam Levin, Gilad Lavi
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Publication number: 20090247953Abstract: An adapter for achieving intradermal dosed delivery of a liquid by use of a dosed drug delivery device including a reservoir having a pierceable septum, the adapter having a connector including an attachment configuration for attachment to the dosed drug delivery device and a hollow needle deployed for piercing the septum. A liquid delivery interface, linked to the connector, includes a straight skin contact edge and one or more hollow microneedle adjacent thereto. The microneedle projects away from the skin contact edge. A flow path arrangement interconnects the needle and the at least one hollow microneedle.Type: ApplicationFiled: December 10, 2006Publication date: October 1, 2009Applicant: NanoPass Technologies Ltd.Inventors: Yehoshua Yeshurun, Yotam Levin, Meir Hefetz, Yoel Sefi, Gilad Lavi
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Patent number: 7588552Abstract: A device (10) and method for transporting fluids across biological barriers enhances penetration of a biological barrier by the use of directional insertion, preferably with asymmetric microneedles (18) and/or microneedles (18) with sharp edges. Additionally, or alternatively, adhesion followed by alteration of contact geometry is employed to stretch the biological barrier across the microneedles (18), thereby also enhancing penetration. Also disclosed is a device (10) and method which combine shallow penetration by hollow microneedles (18) with jet injection via the microneedles (18) to achieve a total liquid penetration depth greater than the mechanical penetration depth of the microneedles (18).Type: GrantFiled: March 4, 2003Date of Patent: September 15, 2009Assignee: Nano Pass Technologies Ltd.Inventors: Yehoshua Yeshurun, Meir Hefetz, Gil Fruchtman, Yotam Levin
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Patent number: D1028236Type: GrantFiled: October 19, 2021Date of Patent: May 21, 2024Assignee: NanoPass Technologies Ltd.Inventors: Gal Admati, Yotam Levin