Abstract: A recombinant thrombin-like enzyme batroxobin expressed by yeast, a production method thereof, and use of the batroxobin as a hemostatic agent or antithrombotic agent is disclosed. In order to express recombinant thrombin-like enzyme, an expression vector is prepared by inserting cDNA encoding the enzyme, the transformed cell is prepared by introducing the expression vector into the cell, the transformed cell then is incubated and the recombinant thrombin-like enzyme is obtained from the cell. The recombinant thrombin-like enzyme may be usefully used as a hemostatic agent because the enzyme effectively decrease bleeding time and blood coagulation time and does not affect various blood coagulation factors.

Abstract: The present invention relates to Saxatilin, a protein derived from the venom of a Korean snake, Agkistrodon saxatilis emelianov, a process for preparing Saxatilin, and pharmaceutical application of the same as anti-platelet aggregation agent and anti-tumor agent. The present inventors purified Saxatilin from the venom of Agkistrodon saxatilis emelianov, cloned its cDNA, and prepared recombinant Saxatilin by culturing a microorganism transformed with an expression vector containing the cDNA. Saxatilin effectively suppresses the platelet aggregation and angiogenesis of tumor cells, which makes possible its practical application as an active ingredient of anti-platelet agent and anti-tumor agent.

Abstract: The present invention relates to Saxatilin, a protein derived from the venom of a Korean snake, Agkistrodon saxatilis emelianov, a process for preparing Saxatilin, and pharmaceutical application of the same as anti-platelet aggregation agent and anti-tumor agent. The present inventors purified Saxatilin from the venom of Agkistrodon saxatilis emelianov, cloned its cDNA, and prepared recombinant Saxatilin by culturing a microorganism transformed with an expression vector containing the cDNA. Saxatilin effectively suppresses the platelet aggregation and angiogenesis of tumor cells, which makes possible its practical application as an active ingredient of anti-platelet agent and anti-tumor agent.

Abstract: A method for controlling a damper of a vehicle is provided, wherein the vehicle includes a front damper and a rear damper and a damping force of the dampers is controlled by respective data detected by a steering angle sensor, a vehicle speed sensor and a yaw rate sensor. First, steering angle data, vehicle speed data and yaw rate data are inputted in step (a) and a desired yaw rate is calculated in step (b) by using the steering angle data, the vehicle speed data and a specification of the vehicle. Then, the desired yaw rate is compared in step (c) with the yaw rate data provided from the yaw rate sensor. Thereafter, it is determined in step (d) whether the vehicle is over-steered or under-steered depending on the comparison result obtained in the step (C). Finally, the damping force of the damper is controlled in step (e) in response to the determination result in the step (d).

Abstract: A damper controlling apparatus of a vehicle includes wheel speed sensors, each wheel speed sensor generating a wheel signal indicating an angular velocity of a corresponding wheel of the vehicle, a vertical velocity calculator for obtaining a signal indicating a vertical velocity of a vehicle body by using the wheel signals from the respective wheel speed sensors and a controller for generating a damper controlling signal by using the vertical velocity signal. The controller has a band pass filter for receiving and processing the wheel signals, a low pass filter for receiving and processing a signal provided from the band pass filter and a compensator for compensating a signal provided from the low pass filter to produce the vertical velocity signal.

Abstract: A method for controlling a damper of a vehicle is provided, wherein the vehicle includes a front damper and a rear damper and a damping force of the dampers is controlled by respective data detected by a steering angle sensor, a vehicle speed sensor and a yaw rate sensor. First, steering angle data, vehicle speed data and yaw rate data are inputted in step (a) and a desired yaw rate is calculated in step (b) by using the steering angle data, the vehicle speed data and a specification of the vehicle. Then, the desired yaw rate is compared in step (c) with the yaw rate data provided from the yaw rate sensor. Thereafter, it is determined in step (d) whether the vehicle is over-steered or under-steered depending on the comparison result obtained in the step (C). Finally, the damping force of the damper is controlled in step (e) in response to the determination result in the step (d).

Abstract: An apparatus for controlling a semi-active suspension system of a vehicle including at least one shock absorber using magneto-rheological fluids. The shock absorber has a rebound valve and a compression valve which are configured such that damping forces of the shock absorber generated in rebound strokes and compression strokes being controlled independently. The apparatus comprises a normal driving control unit for determining a ride value (Sride) and a filtered vehicular vertical velocity (vi) based on a vertical vehicular acceleration, an anti-roll control unit for determining a roll value (Sroll) based on a velocity and a steering angle of the vehicle, and a damping force adjusting unit for controlling the rebound valve and the compression valve of the shock absorber based on the roll value (Sroll), the ride value (Sride) and the filtered vehicular vertical velocity (vi) under a predetermined condition.

Abstract: An apparatus for controlling a semi-active suspension system of a vehicle including at least one shock absorber using magneto-rheological fluids. The shock absorber has a rebound valve and a compression valve which are configured such that damping forces of the shock absorber generated in rebound strokes and compression strokes being controlled independently. The apparatus comprises a normal driving control unit for determining a ride value (Sride) and a filtered vehicular vertical velocity (vi) based on a vertical vehicular acceleration, an anti-roll control unit for determining a roll value (Sroll) based on a velocity and a steering angle of the vehicle, and a damping force adjusting unit for controlling the rebound valve and the compression valve of the shock absorber based on the roll value (Sroll), the ride value (Sride) and the filtered vehicular vertical velocity (vi) under a predetermined condition.

Abstract: A shock absorber includes a cylinder, a piston rod projecting from an upper portion of the cylinder, and an electric motor for adjusting a vehicle height and/or controlling a damping force. The rotational motion of the motor is converted into a linear motion of the piston rod and vice versa.

Abstract: A double-tube shock absorber includes an outer cylinder having a first working chamber, an inner cylinder located inside the first working chamber and having a second working chamber, a first piston movably inserted into the first working chamber and a second piston having a coil and movably inserted into the second working chamber. The first and the second working chamber are filled with a hydraulic fluid and a magnetorheological (MR) fluid, respectively. The first and the second piston have one or more orifices, respectively. The double-tube shock absorber further includes one or more first piston rods for leading the first piston in a reciprocating motion and a second piston rod for leading the second piston in a reciprocating motion. The double-tube shock absorber can sensitively respond to the impulse applied thereto by using the hydraulic fluid having relatively low viscosity and, at the same time, can modulate the damping force by using the MR fluid having changeable viscosity.

Abstract: A shock absorber includes a housing, a cylinder, a piston rod, a piston and a chamber. The housing has an inner space containing a hydraulic fluid. The cylinder has an upper room filled with a magnetorhelogical fluid and a lower room filled with the hydraulic fluid. The piston rod is movably inserted in the upper room of the cylinder. The piston is movably inserted in the lower room of the cylinder, secured to the piston rod and structured to form a magnetic field generator. The chamber is mechanically connected to the piston rod. The piston rod further includes at least first orifice for providing a flowing path for the magnetorheological fluid and the piston further includes at least a second orifice for providing a flowing path for the hydraulic fluid in the lower room of cylinder.

Abstract: The present invention relates to a novel cDNA of direct-acting fibrinolytic serine protease ("Salmonase") which is prepared from a Korean viper, Salmosa(Agkistrodon halys brevicaudus), and a direct-acting fibrinolytic serine protease deduced therefrom. The cDNA of direct-acting fibrinolytic serine protease contains 699 nucleotides coding for 233 amino acids, and the Salmonase translated therefrom consists of two subunits of 77 and 156 amino acids, respectively. Salmonase cDNA of the invention may be expressed in the proper systems established in the recombinant E. coli, yeast, baculovirus/insect cells and other animal cells, and the recombinant Salmonase prepared therefrom can be practically applied as an active ingredient of thrombolytic and hemostatic agents.