Patents by Inventor You-Yeon Won
You-Yeon Won has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
FORUMULATION OF MONODISPERSE KINETICALLY FROZEN POLYMER MICELLES VIA EQUILIBRATION-NANOPRECIPITATION
Publication number: 20230201116Abstract: A formulation and method of micelle production including the steps of dissolving amphiphilic block copolymers in a mixed solvent comprising water and a non-aqueous co-solvent, conducting a single-step dialysis against water or saline in order to produce monodisperse kinetically frozen polymer micelles with DLS size polydispersities less than about 0.2 in aqueous conditions or conducting an evaporation process for removal of non-aqueous solvent content in order to produce monodisperse kinetically frozen polymer micelles with DLS size polydispersities less than about 0.2 in aqueous conditions.Type: ApplicationFiled: June 1, 2021Publication date: June 29, 2023Applicant: Purdue Research FoundationInventors: You-Yeon Won, Daniel James Fesenmeier -
Publication number: 20230139528Abstract: Disclosed herein are fully synthetic polymer-based lung surfactant materials, for the first time, as next generation SRT. In vitro studies on these polymer lung surfactants show that the candidate materials effectively mimic the surface tension controlling properties of currently marketed natural lung surfactants. Further, the polymer lung surfactants have strong protein resistance, which makes this class of materials promising also for potential use in Acute Respiratory Distress Syndrome (ARDS) treatment.Type: ApplicationFiled: November 9, 2022Publication date: May 4, 2023Inventors: You-Yeon Won, Hyun Chang Kim
-
Patent number: 11497764Abstract: Disclosed herein are fully synthetic polymer-based lung surfactant materials, for the first time, as next generation SRT. In vitro studies on these polymer lung surfactants show that the candidate materials effectively mimic the surface tension controlling properties of currently marketed natural lung surfactants. Further, the polymer lung surfactants have strong protein resistance, which makes this class of materials promising also for potential use in Acute Respiratory Distress Syndrome (ARDS) treatment.Type: GrantFiled: November 30, 2020Date of Patent: November 15, 2022Assignee: Purdue Research FoundationInventors: You-Yeon Won, Hyun Chang Kim
-
Publication number: 20220127528Abstract: The present disclosure relates to novel compositions comprising hydrophilic polymer-conjugated bilirubin-coated radio-luminescent particle or particle aggregates, and methods to make and use the novel compositions. A specific novel PEG-BR/CWO NP system provided in this disclosure comprises a CaWO4 nanoparticle (CWO NP) core encapsulated by a poly(ethylene glycol)-bilirubin conjugate micelle (PEG-BR micelle).Type: ApplicationFiled: January 10, 2020Publication date: April 28, 2022Applicant: Purdue Research FoundationInventors: You-Yeon Won, Vincenzo John Pizzuti, Dhushyanth Viswanath
-
Publication number: 20210187010Abstract: Disclosed herein are fully synthetic polymer-based lung surfactant materials, for the first time, as next generation SRT. In vitro studies on these polymer lung surfactants show that the candidate materials effectively mimic the surface tension controlling properties of currently marketed natural lung surfactants. Further, the polymer lung surfactants have strong protein resistance, which makes this class of materials promising also for potential use in Acute Respiratory Distress Syndrome (ARDS) treatment.Type: ApplicationFiled: November 30, 2020Publication date: June 24, 2021Applicant: Purdue Research FoundationInventors: You-Yeon Won, Hyun Chang Kim
-
Publication number: 20200397900Abstract: The present disclosure relates to novel radiation-triggered controlled release drug compositions, and methods to make and use the radiation-triggered controlled release drug compositions. The radiation-triggered controlled drug release nanoparticle formulations may be used to achieve maximum bioavailability and minimum adverse effects of the chemo drugs in chemo radio combination therapy treatment of locally advanced solid tumors.Type: ApplicationFiled: September 7, 2018Publication date: December 24, 2020Applicant: Purdue Research FoundationInventors: You-Yeon WON, Jaewon LEE, Rahul MISRA, Vincenzo PIZZUTI, Kaustabh SARKAR
-
Patent number: 10618998Abstract: This invention provides poly(alkylene carbonate)-based amphiphilic block copolymers, compositions comprising the same, e.g., micelles, and methods of use thereof. This invention further provides methods for preparing the poly(alkylene carbonate)-based amphiphilic block copolymers of the invention.Type: GrantFiled: November 12, 2015Date of Patent: April 14, 2020Assignee: Purdue Research FoundationInventors: You-Yeon Won, Seunggweon Hong, Hoyoung Lee, Jaeyoung Park, Jaewon Lee
-
Publication number: 20200046756Abstract: Disclosed herein are fully synthetic polymer-based lung surfactant materials, for the first time, as next generation SRT. In vitro studies on these polymer lung surfactants show that the candidate materials effectively mimic the surface tension controlling properties of currently marketed natural lung surfactants. Further, the polymer lung surfactants have strong protein resistance, which makes this class of materials promising also for potential use in Acute Respiratory Distress Syndrome (ARDS) treatment.Type: ApplicationFiled: October 22, 2019Publication date: February 13, 2020Applicant: Purdue Research FoundationInventors: You-Yeon Won, Hyun Chang Kim
-
Patent number: 10485820Abstract: Disclosed herein are fully synthetic polymer-based lung surfactant materials, for the first time, as next generation SRT. In vitro studies on these polymer lung surfactants show that the candidate materials effectively mimic the surface tension controlling properties of currently marketed natural lung surfactants. Further, the polymer lung surfactants have strong protein resistance, which makes this class of materials promising also for potential use in Acute Respiratory Distress Syndrome (ARDS) treatment.Type: GrantFiled: January 26, 2018Date of Patent: November 26, 2019Assignee: Purdue Research FoundationInventors: You-Yeon Won, Hyun Chang Kim
-
Publication number: 20180153926Abstract: Disclosed herein are fully synthetic polymer-based lung surfactant materials, for the first time, as next generation SRT. In vitro studies on these polymer lung surfactants show that the candidate materials effectively mimic the surface tension controlling properties of currently marketed natural lung surfactants. Further, the polymer lung surfactants have strong protein resistance, which makes this class of materials promising also for potential use in Acute Respiratory Distress Syndrome (ARDS) treatment.Type: ApplicationFiled: January 26, 2018Publication date: June 7, 2018Applicant: Purdue Research FoundationInventors: You-Yeon Won, Hyun Chang Kim
-
NON-TOXIC FORMULATIONS OF RADIO-LUMINESCENT NANOPARTICLES FOR USE AS CANCER RADIO-SENSITIZING AGENTS
Publication number: 20180008733Abstract: The invention relates generally to a formulation in which metal tungstate or metal molybdate particles are encapsulated within biocompatible, diseased cell-targeting polymeric coatings. Such formulations render metal tungstate or metal molybdate particles suitable for in vivo biomedical imaging and therapeutic applications.Type: ApplicationFiled: January 8, 2016Publication date: January 11, 2018Applicant: Purdue Research FoundationInventors: You-Yeon WON, Jaewon LEE -
Publication number: 20170320992Abstract: This invention provides poly(alkylene carbonate)-based amphiphilic block copolymers, compositions comprising the same, e.g., micelles, and methods of use thereof. This invention further provides methods for preparing the poly(alkylene carbonate)-based amphiphilic block copolymers of the invention.Type: ApplicationFiled: November 12, 2015Publication date: November 9, 2017Applicant: Purdue Research FoundationInventors: You-Yeon Won, Seunggweon Hong, Hoyoung Lee, Jaeyoung Park, Jaewon Lee
-
Patent number: 9782499Abstract: This invention provides block copolymer (BCP) encapsulated nanoparticles. The BCP-encapsulated nanoparticles are used in methods for targeting a tumor, in methods of imaging a tumor and in methods of treating cancer including hyperthermia of tumors. This invention further provides processes for preparation of BCP-encapsulated nanoparticles.Type: GrantFiled: March 15, 2013Date of Patent: October 10, 2017Assignee: Purdue Research FoundationInventors: You-Yeon Won, Ronald P. Andres, Dae Hwan Kim
-
Publication number: 20130261710Abstract: This invention provides block copolymer (BCP) encapsulated nanoparticles. The BCP-encapsulated nanoparticles are used in methods for targeting a tumor, in methods of imaging a tumor and in methods of treating cancer including hyperthermia of tumors. This invention further provides processes for preparation of BCP-encapsulated nanoparticles.Type: ApplicationFiled: March 15, 2013Publication date: October 3, 2013Applicant: Purdue Research FoundationInventors: You-Yeon WON, Ronald P. Andres, Dae Hwan Kim
-
Patent number: 7867512Abstract: The present invention provides biocompatible vesicles comprising semi-permeable, thin-walled encapsulating membranes which are formed in an aqueous solution, and which comprise one or more synthetic super-amphiphilic molecules. When at least one super-amphiphile molecule is a block copolymer, the resulting synthetic vesicle is termed a “polymersome.” The synthetic, reactive nature of the amphiphilic composition enables extensive, covalent cross-linking of the membrane, while maintaining semi-permeability. Cross-linking of the polymer building-block components provides mechanical control and long-term stability to the vesicle, thereby also providing a means of controlling the encapsulation or release of materials from the vesicle by modifying the composition of the membrane. Thus, the encapsulating membranes of the present invention are particularly suited for the reliable, durable and controlled transport, delivery and storage of materials.Type: GrantFiled: February 20, 2007Date of Patent: January 11, 2011Assignees: The Trustees of the University of Pennsylvania, Regents of the University of MinnesotaInventors: Dennis E. Discher, Bohdana M. Discher, You-Yeon Won, James C-M Lee, Daniel A. Hammer, Frank Bates
-
Publication number: 20070218123Abstract: The present invention provides biocompatible vesicles comprising semi-permeable, thin-walled encapsulating membranes which are formed in an aqueous solution, and which comprise one or more synthetic super-amphiphilic molecules. When at least one super-amphiphile molecule is a block copolymer, the resulting synthetic vesicle is termed a “polymersome.” The synthetic, reactive nature of the amphiphilic composition enables extensive, covalent cross-linking of the membrane, while maintaining semi-permeability. Cross-linking of the polymer building-block components provides mechanical control and long-term stability to the vesicle, thereby also providing a means of controlling the encapsulation or release of materials from the vesicle by modifying the composition of the membrane. Thus, the encapsulating membranes of the present invention are particularly suited for the reliable, durable and controlled transport, delivery and storage of materials.Type: ApplicationFiled: February 20, 2007Publication date: September 20, 2007Inventors: Dennis Discher, Bohdana Discher, You-Yeon Won, James C-M Lee, Daniel Hammer, Frank Bates
-
Patent number: 7217427Abstract: The present invention provides biocompatible vesicles comprising semi-permeable, thin-walled encapsulating membranes which are formed in an aqueous solution, and which comprise one or more synthetic super-amphiphilic molecules. When at least one super-amphiphile molecule is a block copolymer, the resulting synthetic vesicle is termed a “polymersome.” The synthetic, reactive nature of the amphiphilic composition enables extensive, covalent cross-linking of the membrane, while maintaining semi-permeability. Cross-linking of the polymer building-block components provides mechanical control and long-term stability to the vesicle, thereby also providing a means of controlling the encapsulation or release of materials from the vesicle by modifying the composition of the membrane. Thus, the encapsulating membranes of the present invention are particularly suited for the reliable, durable and controlled transport, delivery and storage of materials.Type: GrantFiled: July 1, 2004Date of Patent: May 15, 2007Assignees: The Trustees of the University of Pennsylvania, Regents of the University of MinnesotaInventors: Dennis E. Discher, Bohdana M. Discher, You-Yeon Won, James C-M Lee, Daniel A. Hammer, Frank Bates
-
Publication number: 20050048110Abstract: The present invention provides biocompatible vesicles comprising semi-permeable, thin-walled encapsulating membranes which are formed in an aqueous solution, and which comprise one or more synthetic super-amphiphilic molecules. When at least one super-amphiphile molecule is a block copolymer, the resulting synthetic vesicle is termed a “polymersome.” The synthetic, reactive nature of the amphiphilic composition enables extensive, covalent cross-linking of the membrane, while maintaining semi-permeability. Cross-linking of the polymer building-block components provides mechanical control and long-term stability to the vesicle, thereby also providing a means of controlling the encapsulation or release of materials from the vesicle by modifying the composition of the membrane. Thus, the encapsulating membranes of the present invention are particularly suited for the reliable, durable and controlled transport, delivery and storage of materials.Type: ApplicationFiled: July 1, 2004Publication date: March 3, 2005Inventors: Dennis Discher, Bohdana Discher, You-Yeon Won, James Lee, Daniel Hammer, Frank Bates
-
Patent number: 6835394Abstract: The present invention provides biocompatible vesicles comprising semi-permeable, thin-walled encapsulating membranes which are formed in an aqueous solution, and which comprise one or more synthetic super-amphiphilic molecules. When at least one super-amphiphile molecule is a block copolymer, the resulting synthetic vesicle is termed a “polymersome.” The synthetic, reactive nature of the amphiphilic composition enables extensive, covalent cross-linking of the membrane, while maintaining semi-permeability. Cross-linking of the polymer building-block components provides mechanical control and long-term stability to the vesicle, thereby also providing a means of controlling the encapsulation or release of materials from the vesicle by modifying the composition of the membrane. Thus, the encapsulating membranes of the present invention are particularly suited for the reliable, durable and controlled transport, delivery and storage of materials.Type: GrantFiled: December 14, 1999Date of Patent: December 28, 2004Assignee: The Trustees of the University of PennsylvaniaInventors: Dennis E. Discher, Bohdana M. Discher, You-Yeon Won, James C-M. Lee, Frank S. Bates, Daniel A. Hammer