Abstract: Disclosed is an approximate physical simulation integrated debugging method based on digital twinning, which includes the following steps of: a production line simulation model building step, a twinning step, a system debugging step, a hardware-in-the-loop debugging step, and a device-in-the-loop debugging step. The approximate physical simulation integrated debugging system based on digital twinning includes a production line simulation model building module, a twinning module, a system debugging module, a hardware-in-the-loop debugging module, and a device-in-the-loop debugging module. According to the approximate physical simulation integrated debugging method and system based on digital twinning, since a local component twin after being successfully debugged is replaced with an entity component, when a problem occurs after replacement, only the local component twin needs to be debugged and optimized again, thus saving time and reducing cost.