Patents by Inventor Youhai H. Chen

Youhai H. Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • C-Rel-specific siRNA and its use for preventing and treating autoimmune psoriasis
    Patent number: 10081810
    Abstract: The present invention provides a c-Rel-specific siRNA and its use for preventing and treating autoimmune psoriasis. In particular, the c-Rel-specific siRNAs have sequences as shown in SEQ ID Nos. 1-2 or SEQ ID Nos. 3-4. In the present invention, small interfering RNA (siRel) specific to c-Rel are employed to inhibit c-Rel biosynthesis, and prevent and treat autoimmune psoriasis by inhibiting inflammatory factors relating to IL-23/IL-17A inflammatory axis.
    Type: Grant
    Filed: August 18, 2017
    Date of Patent: September 25, 2018
    Assignees: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY, THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Qingguo Ruan, Youhai H. Chen, Tingting Fan, Yifan Ma, Lintao Cai, Shaowen Wang, Xiaochun Wan
  • C-REL-SPECIFIC SIRNA AND ITS USE FOR PREVENTING AND TREATING AUTOIMMUNE PSORIASIS
    Publication number: 20180002698
    Abstract: The present invention provides a c-Rel-specific siRNA and its use for preventing and treating autoimmune psoriasis. In particular, the c-Rel-specific siRNAs have sequences as shown in SEQ ID Nos. 1-2 or SEQ ID Nos. 3-4. In the present invention, small interfering RNA (siRel) specific to c-Rel are employed to inhibit c-Rel biosynthesis, and prevent and treat autoimmune psoriasis by inhibiting inflammatory factors relating to IL-23/IL-17A inflammatory axis.
    Type: Application
    Filed: August 18, 2017
    Publication date: January 4, 2018
    Inventors: Qingguo RUAN, Youhai H. CHEN, Tingting FAN, Yifan MA, Lintao CAI, Shaowen WANG, Xiaochun WAN
  • REL INHIBITORS AND METHODS OF USE THEREOF
    Publication number: 20140066486
    Abstract: This invention provides REL inhibitors which interfere with the DNA binding capacity of a REL protein. Additionally this invention provides methods of treating, abrogating, or preventing diseases which respond with a positive clinical score to a REL inhibitor. Methods of identifying REL inhibitor based on a REL protein three dimensional model are described.
    Type: Application
    Filed: August 27, 2013
    Publication date: March 6, 2014
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Youhai H. CHEN, Ramachandran MURALI, Jing SUN
  • Rel inhibitors and methods of use thereof
    Patent number: 8609730
    Abstract: This invention provides REL inhibitors which interfere with the DNA binding capacity of a REL protein. Additionally this invention provides methods of treating, abrogating, or preventing diseases which respond with a positive clinical score to a REL inhibitor. Methods of identifying REL inhibitor based on a REL protein three dimensional model are described.
    Type: Grant
    Filed: January 7, 2009
    Date of Patent: December 17, 2013
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Youhai H. Chen, Ramachandran Murali, Jing Sun
  • REL INHIBITORS AND METHODS OF USE THEREOF
    Publication number: 20110118325
    Abstract: This invention provides REL inhibitors which interfere with the DNA binding capacity of a REL protein. Additionally this invention provides methods of treating, abrogating, or preventing diseases which respond with a positive clinical score to a REL inhibitor. Methods of identifying REL inhibitor based on a REL protein three dimensional model are described.
    Type: Application
    Filed: January 7, 2009
    Publication date: May 19, 2011
    Inventors: Youhai H. Chen, Ramachandran Murali, Jing Sun