Abstract: The present invention relates to an apicidin composition for inducing differentiation of mesenchymal stem cells into cardiac-committed cells, and a method for inducing differentiation into cardiac-committed cells using the same. The present invention allows mesenchymal stem cells to be specifically induced to differentiate into cardiac-committed cells even when an apicidin is treated for only a very short period of time of 24 hours, thereby being capable of solving the extremely low cardiomyogenic differentiation efficiency of mesenchymal stem cells, high cost, and long-term problems in the conventional art, and thus the present invention can be usefully used for treating heart disease.

Abstract: The present invention relates to an apicidin composition for inducing differentiation of mesenchymal stem cells into cardiac-committed cells, and a method for inducing differentiation into cardiac-committed cells using the same. The present invention allows mesenchymal stem cells to be specifically induced to differentiate into cardiac-committed cells even when an apicidin is treated for only a very short period of time of 24 hours, thereby being capable of solving the extremely low cardiomyogenic differentiation efficiency of mesenchymal stem cells, high cost, and long-term problems in the conventional art, and thus the present invention can be usefully used for treating heart disease.

Abstract: The present invention relates to a method of differentiating mesenchymal stem cells into cardiomyocytes. When the method of the present invention is used, cardiomyocytes may be obtained from mesenchymal stem cells with high efficiency. Therefore, the method of the present invention may be effectively used for treatment of heart diseases, such as heart failure, which require myocardial regeneration for treatment.

Abstract: A pharmaceutical composition and a method for preventing or treating a cardiovascular disease are provided. The pharmaceutical composition includes a BIO compound ((2?Z,3?E)-6-bromoindirubin-3?-oxime) or a pharmaceutically acceptable salt thereof as an active ingredient. The pharmaceutical composition can specifically act on different types of cells constituting heart tissues, that is, can induce the growth of cardiomyocytes, and can also inhibit proliferation of cardiac fibroblasts and strongly suppress inflammatory mediators in macrophages, thereby significantly recovering the tissues and functions of the heart after the onset of myocardial infarction. Therefore, the pharmaceutical composition can be effectively used to treat various cardiovascular diseases including myocardial infarction.

Abstract: A pharmaceutical composition and a method for preventing or treating a cardiovascular disease are provided. The pharmaceutical composition includes a BIO compound ((2?Z,3?E)-6-bromoindirubin-3?-oxime) or a pharmaceutically acceptable salt thereof as an active ingredient. The pharmaceutical composition can specifically act on different types of cells constituting heart tissues, that is, can induce the growth of cardiomyocytes, and can also inhibit proliferation of cardiac fibroblasts and strongly suppress inflammatory mediators in macrophages, thereby significantly recovering the tissues and functions of the heart after the onset of myocardial infarction. Therefore, the pharmaceutical composition can be effectively used to treat various cardiovascular diseases including myocardial infarction.

Abstract: The present invention relates to methods and compositions for reducing or preventing ischemia-reperfusion injury. Methods for identifying candidate compounds for such treatment are also described.