Abstract: The present disclosure relates to a soluble microneedle and a filler composition with an excellent anti-wrinkle effect. Using the microneedle according to the present disclosure, crosslinked hyaluronic acid (hyaluronic acid filler material) can be intradermally or subcutaneously administered by a simple method, and a swelling property of the crosslinked hyaluronic acid is improved after administration, thereby exhibiting the excellent anti-wrinkle effect.

Abstract: The present disclosure relates to a method for manufacturing a microneedle containing a coating part on a needle tip and an apparatus used for the method. When a microneedle is manufactured using the coating method and apparatus according to the present disclosure, a coating part in which a target material is impregnated can be easily inserted into skin and effective dissolution is possible. Further, the target material is allowed to show excellent skin permeability with the dissolution of the coating part of the microneedle manufactured according to the present disclosure, thereby a quantitative amount of target material can be effectively delivered into the skin.

Abstract: The present disclosure relates to an apparatus and a process which can continuously produce microneedles using a conveyor system and decomposition or vacuum. By using the microneedle production method and apparatus according to the present disclosure, continuous mass production of microneedles is available, and therefore it is possible to reduce the input of manpower and produce a large amount of products compared to the conventional production method.

Abstract: The present disclosure relates to an apparatus and a process which can continuously produce microneedles using a conveyor system and decomposition or vacuum. By using the microneedle production method and apparatus according to the present disclosure, continuous mass production of microneedles is available, and therefore it is possible to reduce the input of manpower and produce a large amount of products compared to the conventional production method.

Abstract: The present invention relates to a system for administering a poorly-soluble compound to the skin, the system being capable of exerting an excellent effect by stably impregnating the poorly-soluble compound and effectively delivering the poorly-soluble compound into the skin, and the present invention is technically characterized by a microneedle to which microparticles comprising a poorly-soluble compound are added. In addition, the present invention provides a method for administering a poorly-soluble compound to the skin, the method being characterized by using the microneedle.

Abstract: The present disclosure relates to a method for manufacturing a microneedle containing a coating part on a needle tip and an apparatus used for the method. When a microneedle is manufactured using the coating method and apparatus according to the present disclosure, a coating part in which a target material is impregnated can be easily inserted into skin and effective dissolution is possible. Further, the target material is allowed to show excellent skin permeability with the dissolution of the coating part of the microneedle manufactured according to the present disclosure, thereby a quantitative amount of target material can be effectively delivered into the skin.

Abstract: The present disclosure relates to a soluble microneedle and a filler composition with an excellent anti-wrinkle effect. Using the microneedle according to the present disclosure, crosslinked hyaluronic acid (hyaluronic acid filler material) can be intradermally or subcutaneously administered by a simple method, and a swelling property of the crosslinked hyaluronic acid is improved after administration, thereby exhibiting the excellent anti-wrinkle effect.

Abstract: A skin administration system capable of ensuring the stability of peptides or proteins and enhancing the delivery rate of peptides or proteins through the skin and, more particularly, microneedles including peptides or proteins are provided. Microneedles including a protein or peptide are also provided, in particular microneedles including a microparticle including a peptide or a protein, in particular wherein the peptide or the protein is stably entrapped inside the microparticle, more particularly without aggregation. The material forming the microneedle can be soluble in the skin and the protein or the peptide can be stably delivered into the skin as the microneedle is dissolved or disintegrated when the microneedle is applied to the skin.

Abstract: The present invention relates to a soluble microneedle and, more particularly, to a microneedle and a microneedle patch comprising the same, wherein the microneedle is used to perforate skin, and the microneedle, when inserted through the perforated skin, is then dissolved, thereby administering the target material from inside the microneedle into the skin. The microneedle according to the present invention, when used, has appropriate levels of mechanical strength, viscosity, and hardness and can be easily inserted into skin without undergoing shape change, for example, bending or breaking, thereby enabling efficient skin perforation. In addition, as the microneedle according to the present invention is dissolved through the perforated skin, the target material penetrates the skin at an excellent ratio. Accordingly, there is no need to apply strong force, and the target material can be effectively delivered into the skin regardless of which part of the microneedle contains the target material.

Abstract: The present invention relates to a skin administration system capable of ensuring the stability of peptides or proteins and enhancing the delivery rate of peptides or proteins through the skin and, more particularly, to a microneedle comprising peptides or proteins.

Abstract: The present invention relates to a system for administering a poorly-soluble compound to the skin, the system being capable of exerting an excellent effect by stably impregnating the poorly-soluble compound and effectively delivering the poorly-soluble compound into the skin, and the present invention is technically characterized by a microneedle to which microparticles comprising a poorly-soluble compound are added. In addition, the present invention provides a method for administering a poorly-soluble compound to the skin, the method being characterized by using the microneedle.

Abstract: The present disclosure relates to a system for administering retinol into skin that ensures stability of retinol, reduces skin irritation of retinol, and continues to exert effects, wherein the system is a microneedle including microparticles containing retinol or retinol derivatives. The present disclosure further provides a method for manufacturing a retinol administration system that reduces skin irritation, exerts effects of retinol for a long time, and ensures stability of retinol very unstable to light, wet and temperature. The present disclosure further provides a method for administering retinol into skin using the microneedle.

Abstract: Provided herein is a three-dimensional shape measurement apparatus capable of measuring a shape of a measurement object using an interferometer and color information of the measurement object, the apparatus including a light source for emitting a light; a light divider for reflecting the light emitted from the light source or transmitting a light reflected by the measurement object; a lens unit for focusing the light reflected by the light divider onto the measurement object; a light detector for detecting the light reflected from the measurement object; and a light adjuster arranged on a light path between the light source and the light divider, and configured to interrupt the light being emitted from a central area of the light source to reduce interference of light occurring in the lens unit.

Abstract: Provided herein is a three-dimensional shape measurement apparatus capable of measuring a shape of a measurement object using an interferometer and color information of the measurement object, the apparatus including a light source for emitting a light; a light divider for reflecting the light emitted from the light source or transmitting a light reflected by the measurement object; a lens unit for focusing the light reflected by the light divider Onto the measurement object; a light detector for detecting the light reflected from the measurement object; and a light adjuster arranged on a light path between the light source and the light divider, and configured to interrupt the light being emitted from a central area of the light source to reduce interference of light occurring in the lens unit.

Abstract: A liquid crystal display panel cutting system for cutting a substrate by varying a driving condition of a cutting wheel according to characteristics the glass substrate. The system comprising a table on which the substrate is loaded, a cutting wheel for forming scribing lines at a surface of the substrate, and a controller for driving the cutting wheel by controlling a driving condition of the cutting wheel based upon the characteristics of the substrate.

Abstract: Disclosed is a method for measuring a thickness of a subjecting layer attached on a base layer by means of an interferometer, which includes the steps of: obtaining a correlation equation of a phase difference with respect to thicknesses of sample layers, the thicknesses being different from each other, the sample layers being made from a material substantially equal to a material of the subjecting layer; obtaining a first interference signal with respect to an optical axial direction incident to the base layer at a boundary surface between an air layer and the base layer; obtaining a second interference signal with respect to the optical axial direction at a boundary surface between the subjecting layer and the base layer; obtaining a phase difference between a phase of the first interference signal and a phase of the second interference signal at respective heights substantially equal to each other with respect to the optical axial direction; and determining a thickness of the subjecting layer by inserting

Abstract: A thickness measurement apparatus includes a beam splitter for reflecting or transmitting a ray irradiated from an optical source or a ray reflected by a measurement object; a first lens part which condenses a ray to the measurement object and generates a reference ray; a second lens part for condensing a ray to the object to be measured; an interference light detector for detecting an interference signal generated by the reflected ray and reference ray; a spectroscopic detector corresponding to the second lens part to form a light path different from the path formed by the interference light detector and splits the ray reflected by the measurement object to detect an intensity and wavelength of each split ray; and a light path converter for selectively transmitting a ray to the interference light detector or spectroscopic detector, wherein position exchanging is performed between the first second lens parts.

Abstract: A grinder wheel for a liquid crystal display device and a method of fabricating a liquid crystal display device using the same are provided. Two grinding surfaces are formed in the grinder wheel used for grinding a substrate so that it is possible to improve grinding characteristics, to increase the life of the grinder wheel, and to reduce grinding time. The method includes cutting the substrates attached to each other into a plurality of unit liquid crystal display panels, loading the unit liquid crystal display panel on a grinding table, grinding a predetermined region of the liquid crystal display panel using a grinder wheel including two grinding surfaces of a first grinder surface for primary grinding and a second grinder surface for secondary grinding, and unloading the ground liquid crystal display panel.

Abstract: An apparatus for measuring a thickness, which includes: a first beam splitter for reflecting or transmitting a ray irradiated from an optical source or a ray reflected by a measurement object; a first lens part which condenses a ray to the measurement object and generates a reference ray having a difference of a light path in comparison with a ray reflected by the measurement object; a second lens part for condensing a ray to the object to be measured; an interference light detector which corresponds to at the first lens part so as to form a light path and detects an interference signal generated by the ray reflected by the measurement object and the reference ray; a spectroscopic detector which corresponds to the second lens part so as to form a light path different from the light path formed by the interference light detector and splits the ray reflected by the measurement object so as to detect an intensity and a wavelength of each split ray; and a light path converter for selectively transmitting a ray to

Abstract: Disclosed is a method for measuring a thickness of a subjecting layer attacked on a base layer by means of an interferometer, which includes the steps of: obtaining a correlation equation of a phase difference with respect to thicknesses of sample layers, the thicknesses being different from each other, the sample layers being made from a material substantially equal to a material of the subjecting layer; obtaining a first interference signal with respect to an optical axial direction incident to the base layer at a boundary surface between an air layer and the base layer; obtaining a second interference signal with respect to the optical axial direction at a boundary surface between the subjecting layer and the base layer; obtaining a phase difference between a phase of the first interference signal and a phase of the second interference signal at respective heights substantially equal to each other with respect to the optical axial direction; and determining a thickness of the subjecting layer by inserting