Abstract: An earbud, including a housing, a speaker assembly, and a partition, is provided. The housing includes a sound outlet hole and a sound tuning hole, wherein the sound outlet hole is in acoustic communication with an ear canal of a human ear but does not contact the ear canal. The speaker assembly is disposed in the housing to separate a space in the housing into a front cavity and a rear cavity. The partition is disposed in the front cavity of the housing to divide the front cavity into a first area close to the speaker assembly and a second area away from the speaker assembly. The partition is between the first area and the second area, and the partition has a thickness and includes multiple first through holes, wherein the first through holes pass through the partition to connect the first area with the second area.

Abstract: A PEGylated cyclopamine analog, preparation method, uses thereof and methods for treating proliferative diseases using the same are disclosed. The PEGylated cyclopamine analog is a compound represented by the following formula I, a compound comprising at least one group represented by the following formula I (in formula I, R is straight or branched polyethylene glycol having a molecular weight between 200 and 200,000 Dalton, L and X are linking groups), or their single enantiomers, mixture of enantiomers, mixture of diastereomers, pharmaceutically acceptable salts, solvates, or hydrates.

Abstract: A PEGylated cyclopamine analog, preparation method, uses thereof and methods for treating proliferative diseases using the same are disclosed. The PEGylated cyclopamine analog is a compound represented by the following formula I, a compound comprising at least one group represented by the following formula I (in formula I, R is straight or branched polyethylene glycol having a molecular weight between 200 and 200,000 Dalton, L and X are linking groups), or their single enantiomers, mixture of enantiomers, mixture of diastereomers, pharmaceutically acceptable salts, solvates, or hydrates.