Abstract: A monomeric bispecific polyethylene glycol (PEG) engager that includes an anti-PEG Fab fused to a disulfide stabilized scFv that specifically binds to a cell surface antigen. The PEG engager, in the absence of PEG, remains monomeric upon binding to the cell surface antigen on a cell and remains on the surface of the cell. Also provided is a method for treating cancer by administering a PEG engager followed by a PEGylated anti-cancer agent. A kit that contains a PEG engager and a PEGylated anti-cancer agent is also disclosed. Further disclosed are methods for imaging cells and diagnosing cancer by administering a PEG engager followed by a PEGylated imaging agent. Another kit is provided that includes the PEG engager and the PEGylated imaging agent.

Abstract: A soldering process method includes steps of: establishing a material component database; establishing a working parameter database; analyzing material and component characteristics required for a new soldering process; comparing the characteristics with information in the material component database; selecting operating parameters corresponding to the material and component characteristics similar to those required for the new soldering process; performing the soldering process using the operating parameters corresponding to the material and component characteristics similar to those required for the new soldering process; measuring and recording the soldering process execution information and the final product information; determining whether the final product of the solder process meets the quality control requirements; using the machine learning method to fit the soldering process execution information and the final product information of the solder process to get the operating parameters for the next sol

Abstract: Disclosed herein is a bi-specific antibody that specifically directs a therapeutic agent to a cancer cell by targeting a tumor antigen of the cancer cell, and thereby suppressing the growth of the cancer or blocking the invasion or metastasis of the cancer. The bi-specific antibody of the present disclosure includes a first antigen binding site that binds to polyethylene glycol (PEG); and a second antigen binding site that binds to a target ligand, such as a tumor antigen.

Abstract: Disclosed herein is a bi-specific antibody that specifically directs a therapeutic agent to a cancer cell by targeting a tumor antigen of the cancer cell, and thereby suppresses the growth of the cancer or blocking the invasion or metastasis of the cancer. The bi-specific antibody of the present disclosure includes a first antigen binding site that binds to polyethylene glycol (PEG); and a second antigen binding site that binds to a target ligand, such as a tumor antigen.

Abstract: Disclosed herein is a bi-specific antibody that specifically directs a therapeutic agent to a cancer cell by targeting a tumor antigen of the cancer cell, and thereby suppressing the growth of the cancer or blocking the invasion or metastasis of the cancer. The bi-specific antibody of the present disclosure includes a first antigen binding site that binds to polyethylene glycol (PEG); and a second antigen binding site that binds to a target ligand, such as a tumor antigen.

Abstract: The present disclosure illustrates an acoustic echo cancellation method and system using the same. The acoustic echo cancellation method comprises the following steps. Firstly, a prior-knowledge matrix comprising a plurality of space vectors is built. Then, an initial filter vector is generated by the prior-knowledge matrix and an initial weighting vector. The weighting vector is updated based on the difference of the echo signal and the estimated signal in an iteration algorithm, and the coefficient of the filter vector is updated according to the updated weighting vector. An estimated signal is generated according to the updated filter vector and the original signal. Finally, the next echo signal is cancelled by the near-end estimated signal.

Abstract: Disclosed herein is a bi-specific antibody that specifically directs a therapeutic agent to a cancer cell by targeting a tumor antigen of the cancer cell, and thereby suppresses the growth of the cancer or blocking the invasion or metastasis of the cancer. The bi-specific antibody of the present disclosure includes a first antigen binding site that binds to polyethylene glycol (PEG); and a second antigen binding site that binds to a target ligand, such as a tumor antigen.

Abstract: The electroplating equipment disposes a hollow first ring between a first mold and a through hole of a workpiece, and a hollow second ring between a second mold and the through hole of the workpiece, such that the first ring and the second ring provide substantially equivalent channel as the openings of the through hole when the first mold and the second mold are set to hold tight the workpiece. The first ring and the second ring, along with an injection channel of the first mold and a recycling channel of the second mold and the through hole of the workpiece, form a seamless flow channel for an electroplating fluid to flow and be electroplated on the wall of the through hole.

Abstract: The present disclosure illustrates an acoustic echo cancellation method and system using the same. The acoustic echo cancellation method comprises the following steps. Firstly, a prior-knowledge matrix comprising a plurality of space vectors is built. Then, an initial filter vector is generated by the prior-knowledge matrix and an initial weighting vector. The weighting vector is updated based on the difference of the echo signal and the estimated signal in an iteration algorithm, and the coefficient of the filter vector is updated according to the updated weighting vector. An estimated signal is generated according to the updated filter vector and the original signal. Finally, the next echo signal is cancelled by the near-end estimated signal.

Abstract: The electroplating equipment disposes a hollow first ring between a first mold and a through hole of a workpiece, and a hollow second ring between a second mold and the through hole of the workpiece, such that the first ring and the second ring provide substantially equivalent channel as the openings of the through hole when the first mold and the second mold are set to hold tight the workpiece. The first ring and the second ring, along with an injection channel of the first mold and a recycling channel of the second mold and the through hole of the workpiece, form a seamless flow channel for an electroplating fluid to flow and be electroplated on the wall of the through hole.

Abstract: A method for providing interne services for socialization purposes sends an identity data and a location data to a server. The method further converts the identity data and the location data into a profile status data. The method further retrieves a social organization and a character profile of the identity data and determines whether the character profile satisfies a predetermined condition. The identity data is given an authority for predetermined privileged operations or given a right of organization selection. In another embodiment, the identity data is belongs to a social organization having a territory. The method calculates a movement distance based on the location data and the territory, as well as a length of movement time based on the movement distance and a character profile of the identity data. The length of movement time is proportional to the movement distance but is inversely proportional to the character profile.

Abstract: This disclosure relates to a method to mimicking the germinal center reaction to generate antibodies with altered binding properties or increased affinity directly in hybridomas. To allow convenient and rapid affinity maturation of antibodies, a controllable activation-induced cytidine deaminase (AID) expression system to induce somatic hypermutation in hybridomas is developed. Selection of high affinity antibodies is achieved by fluorescence-activated cell sorting of hybridomas that preferentially bind fluorescence-labeled antigens. The disclosure also relates to de novo generation of hybridomas with tunable antibody affinity by generating myeloma fusion partners with controllable AID expression.

Abstract: The present invention provides an apparatus for controlling a three-dimensional optical field. The apparatus includes a light-emission device and a set of zoom elements. The light-emission device emits a light. The set of zoom elements are disposed in front of the light-emission device, and focus the light from the light-emission device.

Abstract: A method for providing internet services for socialization purposes sends an identity data and a location data to a server. The method further converts the identity data and the location data into a profile status data. The method further retrieves a social organization and a character profile of the identity data and determines whether the character profile satisfies a predetermined condition. The identity data is given an authority for predetermined privileged operations or given a right of organization selection. In another embodiment, the identity data is belonged to a social organization having a territory. The method calculates a movement distance based on the location data and the territory, as well as a length of movement time based on the movement distance and a character profile of the identity data. The length of movement time is proportional to the movement distance but is inversely proportional to the character profile.

Abstract: A biological detecting chip comprising an optical fiber, at least one gas filter, an upper cap and a substrate is disclosed. The optical fiber has at least one detecting area disposed on an outer surface. The upper cap has at least two guiding channels passed through the upper cap, at least one discharge channel with two ends connecting to an upper portion of distinct guiding channels, an inlet and an outlet, wherein the gas filter is attached to an upside of the discharge channel to separate the discharge channel and an outside of the upper cap. The substrate has a test area and a plurality of directing channels, wherein the directing channel connects to the inlet and the guiding channel, connects to the guiding channel and the test area, and connects to the test area and the outlet.

Abstract: The present invention provides an apparatus for controlling a three-dimensional optical field. The apparatus includes a light-emission device and a set of zoom elements. The light-emission device emits a light. The set of zoom elements are disposed in front of the light-emission device, and focus the light from the light-emission device.

Abstract: A recombinant DNA construct is provided and includes a first DNA fragment encoding a ?-glucuronidase and a second DNA fragment encoding a membrane anchoring domain. The ?-glucuronidase may be a human ?-glucuronidase or a mouse ?-glucuronidase. In one embodiment, an expression vector for delivering a gene of interest or portion thereof into a host cell includes a DNA sequence for the gene of interest, a first DNA fragment encoding a ?-glucuronidase, and a second DNA fragment encoding a membrane anchoring domain. In another embodiment, a method of introducing a gene of interest or portion thereof into a host cell is provided, including introducing into the host cell a recombinant DNA construct.

Abstract: A procedure for the installation of clean room processing tools which require rough pumping equipment located in areas outside of the clean room. Instead of simultaneously installing and testing the pumping equipment and the processing tool, the pumping equipment is installed first along with its associated support services. Foreline piping, terminating in the proximity of the processing tool vacuum port is also installed and capped off at this time. Functional testing and qualification of the rough pumping equipment is done and then the processing tool is moved into place and connected to the pumping line on the clean room floor. This independent and sequential installation procedure reduces perturbations of on-going manufacturing activity in the clean room area and also minimizes the risk of costly damage to the processing tool by faulty, un-tested, pumping equipment.

Abstract: A procedure for the installation of clean room processing tools which require rough pumping equipment located in areas outside of the clean room. Instead of simultaneously installing and testing the pumping equipment and the processing tool, the pumping equipment is installed first along with its associated support services. Foreline piping, terminating in the proximity of the processing tool vacuum port is also installed and capped off at this time. Functional testing and qualification of the rough pumping equipment is done and then the processing tool is moved into place and connected to the pumping line on the clean room floor. This independent and sequential installation procedure reduces perturbations of on-going manufacturing activity in the clean room area and also minimizes the risk of costly damage to the processing tool by faulty, un-tested, pumping equipment.