Patents by Inventor Yu-Hui Rogers

Yu-Hui Rogers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for determining the nucleotide sequence of a polynucleotide
    Publication number: 20020192662
    Abstract: The invention provides a kit and a solid phase sequencing method for determining the sequence of nucelic acid molecules, and particularly the sequence of regions of nucleic acid molecules in which variation from the normal sequence is associated with disease.
    Type: Application
    Filed: September 24, 2001
    Publication date: December 19, 2002
    Inventors: Michael T. Boyce-Jacino, Yu-Hui Rogers, Philip Goelet
  • Method for analyzing the nucleotide sequence of a polynucleotide by oligonucleotide extension on an array
    Patent number: 6294336
    Abstract: The present invention provides a method for determining the nucleotide sequence of a nucleic acid molecule using primer oligonucleotides arrayed on a solid support and doing primer extension. By providing sequence information from both oligonucleotide primers in which the 3′ terminal nucleotide of the oligonucleotide primer is hybridized to the nucleic acid molecule and oligonucleotide primers in which the 3′ terminal nucleotide is not hybridized to the nucleic acid molecule the invention is advantageous in that less primers are needed to fully sequence a nucleic acid molecule.
    Type: Grant
    Filed: March 9, 2000
    Date of Patent: September 25, 2001
    Assignee: Orchid Biosciences, Inc.
    Inventors: Michael T. Boyce-Jacino, Yu-Hui Rogers, Philip Goelet
  • Gene pen devices for array printing
    Patent number: 6235473
    Abstract: The invention concerns an apparatus for printing arrays of molecules and methods for printing these arrays. More particularly, the invention relates to a gene pen apparatus that may be used for delivering arrays of oligonucleotides on solid supports from a multiplicity of reagent reservoirs through flow controlling means. The flow controlling means may for example, be either a pin valve means or a wicking means.
    Type: Grant
    Filed: July 2, 1998
    Date of Patent: May 22, 2001
    Assignee: Orchid BioSciences, Inc.
    Inventors: Mitchell Friedman, Yu-Hui Rogers, Michael Boyce-Jacino
  • Covalent attachment of nucleic acid molecules onto solid-phases via disulfide bonds
    Patent number: 6030782
    Abstract: Methods for the covalent, specific and reversible immobilization of nucleic acid molecules onto solid-phases by means of a reversible disulfide bond for nucleic acid molecule array preparation are described. These methods can be used to prepare reusable nucleic acid molecule arrays with hilgh specificity and high efficiency.
    Type: Grant
    Filed: November 21, 1997
    Date of Patent: February 29, 2000
    Assignee: Orchid Biocomputer, Inc.
    Inventors: Steve Anderson, Yu-Hui Rogers
  • Covalent attachment of nucleic acid molecules onto solid-phases via disulfide bonds
    Patent number: 5837860
    Abstract: Methods for the covalent, specific and reversible immobilization of nucleic acid molecules onto solid-phases by means of a reversible disulfide bond for nucleic acid molecule array preparation are described. These methods can be used to prepare reusable nucleic acid molecule arrays with high specificity and high efficiency.
    Type: Grant
    Filed: March 5, 1997
    Date of Patent: November 17, 1998
    Assignee: Molecular Tool, Inc.
    Inventors: Stephen Anderson, Yu-Hui Rogers