Abstract: A water-air integrated search and rescue system includes a flight power module, a navigation power module, a biomimetic boat module, a drone, and an integrated control module. The integrated control module is configured to acquire weather information and determine whether to send a flight signal to the flight power module or to send a navigation signal to the navigation power module based on the weather information; the flight power module is configured to fly the drone to a search and rescue region after receiving the flight signal; the navigation power module is configured to navigate the drone to the search and rescue region after receiving the navigation signal; the integrated control module is further configured to control the drone to deploy the biomimetic boat module; and the biomimetic boat module is configured to carry out search and rescue work in the search and rescue region.

Abstract: The invention discloses a center lock structure, comprises a chassis, rotary sliding sleeve and a center rod, the top of the rotary sliding sleeve is circumferentially and slidely connected with the chassis; and the center rod is extended into the rotary sliding sleeve along the top of the chassis, an elastic member is provided at one side on the bottom of the center rod, the elastic member is exposed outside the center rod when there is no external force, and the elastic member is concealed in the center rod when squeezed by an external force; in the invention, by the center rod, upper and lower rotary sliding sleeve, through holes and the accommodating grooves for pressing or releasing the elastic member, the structure can be unlocked by rotation and pull-down.

Abstract: Disclosed is an intelligent collision avoidance method for a swarm of unmanned surface vehicles based on deep reinforcement learning; firstly, a theoretical framework of autonomous learning collision avoidance of a swarm of unmanned surface vehicles based on deep reinforcement learning is proposed, and the LSTM neural network memory ability is integrated to realize the continuity of collision avoidance actions; then, according to the USV environment in the framework, the characterization method is obtained, and the USV collision avoidance reward and punishment function is proposed to evaluate the collision avoidance effect; finally, an intelligent collision avoidance training system for a swarm of unmanned surface vehicles is formed. The simulation and verification of this disclosure show that the USV trained in this disclosure can navigate safely in the collision avoidance environment with a swarm of unmanned surface vehicles and realize intelligent collision avoidance.

Abstract: Provided is a traditional Chinese herbal composition for treating pulmonary nodules, a preparation method thereof, and a honeyed pill. The composition comprises: 30 parts by weight of Ziziphi Spinosae Semen, 20-30 parts by weight of Rehmaniae Radix, 30 parts by weight of Trichosanthis Radix, 40-50 parts by weight of Paeoniae Radix Alba, 30 parts by weight of Coicis Semen Preparata, 20 parts by weight of Ginseng Radix et Rhizoma, 10 parts by weight of Olibanum, 10 parts by weight of Myrrha, 20-30 parts by weight of Testudinis Carapax et Plastrum Preparata Cum Aceto, 20-30 parts by weight of Trionycis Carapax Preparata Cum Aceto, 30 parts by weight ofAgrimoniae Herba, 10-20 parts by weight ofAlpiniae Oxyphyllae Fructus, 5 parts by weight of Toosendan Fructus, 20 parts by weight of Poria, 10 parts by weight of Platycodonis Radix, and 10 parts by weight of Polygalae Radix.

Abstract: A method and a device for securing a cache against side channel attacks are provided. An allocator identifier ALLOCATOR field is added to each cache entry in the present disclosure. Whenever an entry is allocated in the cache, the identifier of the software domain currently running on the processor is filled into the ALLOCATOR field of the allocation entry. When accessing the cache, the cache entry can be hit only if the identifier of the software domain currently running on the processor is identical to the ALLOCATOR field in the cache entry. If the cache entry to be replaced is invalid or its ALLOCATOR field is identical to the identifier of the software domain currently running on the processor, then the existing entry in the cache is replaced directly; otherwise, the entire cache is emptied.

Abstract: A method and a device for securing a cache against side channel attacks are provided. An allocator identifier ALLOCATOR field is added to each cache entry in the present disclosure. Whenever an entry is allocated in the cache, the identifier of the software domain currently running on the processor is filled into the ALLOCATOR field of the allocation entry. When accessing the cache, the cache entry can be hit only if the identifier of the software domain currently running on the processor is identical to the ALLOCATOR field in the cache entry. If the cache entry to be replaced is invalid or its ALLOCATOR field is identical to the identifier of the software domain currently running on the processor, then the existing entry in the cache is replaced directly; otherwise, the entire cache is emptied.

Abstract: The present invention relates to a mutant G-CSF fusion protein. The mutant G-CSF fusion protein is a fusion protein having the activity of stimulating the proliferation of neutrophilic granulocytes, and having a basic structure of G-CSF/carrier protein or carrier protein/G-CSF; wherein the G-CSF moiety comprises multipoint substitutions thus resulting in changes in biological activity and binding affinity. Compared with existing products, the mutant G-CSF fusion protein in the present invention has longer half-life and higher biological activity. Administration of the pharmaceutical preparation containing this mutant G-CSF fusion protein could be used in the treating neutropenia.

Abstract: The present invention relates to an arginine deiminase mutant with partial lysine-deficient and preparation and application thereof. The arginine deiminase mutant of the present invention has enzymatic activity of degrading arginine into citruline; compared with the arginine deiminase with the amino acid sequence of SEQ ID NO: 1, the amino acid sequence comprises one or more of K9N, T, K59Q, K66R, A, K93E, A, Q, K111R, A, K119Q, L, M, K121Q, I, K122E, L, K126E, S, R, K178I, E, D, K196I, R, K209G, T, D, K243E, V, R, K249D, Q, K263N, Q, K279Y, T, K293R, H, E, K325V, I, K380T, R, E, and K406E, D, S substitutions. Compared with PEG modified natural derived arginine deiminase, the PEG modified arginine deiminase mutant of the present invention retain better bioactivity; and because the quantity of lysine in arginine deiminase is reduced, the PEG modified products are more uniform and can be applied to clinical treatment of hepatoma, melanoma and the like.

Abstract: The present invention relates to a mutant G-CSF fusion protein. The mutant G-CSF fusion protein is a fusion protein having the activity of stimulating the proliferation of neutrophilic granulocytes, and having a basic structure of G-CSF/carrier protein or carrier protein/G-CSF; wherein the G-CSF moiety comprises multipoint substitutions thus resulting in changes in biological activity and binding affinity. Compared with existing products, the mutant G-CSF fusion protein in the present invention has longer half-life and higher biological activity. Administration of the pharmaceutical preparation containing this mutant G-CSF fusion protein could be used in the treating neutropenia.

Abstract: The present invention relates to an arginine deiminase mutant with partial lysine-deficient and preparation and application thereof. The arginine deiminase mutant of the present invention has enzymatic activity of degrading arginine into citruline; compared with the arginine deiminase with the amino acid sequence of SEQ ID NO: 1, the amino acid sequence comprises one or more of K9N, T, K59Q, K66R, A, K93E, A, Q, K111R, A, K119Q, L, M, K121Q, I, K122E, L, K126E, S, R, K178I, E, D, K196I, R, K209G, T, D, K243E, V, R, K249D, Q, K263N, Q, K279Y, T, K293R, H, E, K325V, I, K380T, R, E, and K406E, D, S substitutions. Compared with PEG modified natural derived arginine deiminase, the PEG modified arginine deiminase mutant of the present invention retain better bioactivity; and because the quantity of lysine in arginine deiminase is reduced, the PEG modified products are more uniform and can be applied to clinical treatment of hepatoma, melanoma and the like.