Patents by Inventor Yu-kwan Tong

Yu-kwan Tong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Marker for prenatal diagnosis and monitoring
    Patent number: 11597977
    Abstract: The present invention relates to new methods for diagnosing a pregnancy-associated disorder by analyzing fetal DNA present in the mother's blood. More specifically, this invention relies on the discovery that the maspin gene is differentially methylated in fetal DNA and in maternal DNA and provides these new diagnostic methods, which distinguish fetal DNA from maternal DNA and detect prenatal disorders based on abnormalities in fetal DNA level and methylation status.
    Type: Grant
    Filed: March 2, 2020
    Date of Patent: March 7, 2023
    Assignee: The Chinese University of Hong Kong
    Inventors: Yuk Ming Dennis Lo, Wai Kwun Rossa Chiu, Stephen Siu Chung Chim, Yu-Kwan Tong, Chunming Ding
  • MARKER FOR PRENATAL DIAGNOSIS AND MONITORING
    Publication number: 20200270694
    Abstract: The present invention relates to new methods for diagnosing a pregnancy-associated disorder by analyzing fetal DNA present in the mother's blood. More specifically, this invention relies on the discovery that the maspin gene is differentially methylated in fetal DNA and in maternal DNA and provides these new diagnostic methods, which distinguish fetal DNA from maternal DNA and detect prenatal disorders based on abnormalities in fetal DNA level and methylation status.
    Type: Application
    Filed: March 2, 2020
    Publication date: August 27, 2020
    Inventors: YUK MING DENNIS LO, Wai Kwun Rossa Chiu, Stephen Siu Chung Chim, Yu-Kwan Tong, Chunming Ding
  • Marker for prenatal diagnosis and monitoring
    Patent number: 10604808
    Abstract: The present invention relates to new methods for diagnosing a pregnancy-associated disorder by analyzing fetal DNA present in the mother's blood. More specifically, this invention relies on the discovery that the maspin gene is differentially methylated in fetal DNA and in maternal DNA and provides these new diagnostic methods, which distinguish fetal DNA from maternal DNA and detect prenatal disorders based on abnormalities in fetal DNA level and methylation status.
    Type: Grant
    Filed: December 14, 2017
    Date of Patent: March 31, 2020
    Assignee: The Chinese University of Hong Kong
    Inventors: Yuk Ming Dennis Lo, Rossa Wai Kwun Chiu, Stephen Siu Chung Chim, Yu-Kwan Tong, Chunming Ding
  • Methods and kits for selectively amplifying, detecting or quantifying target DNA with specific end sequences
    Patent number: 10329606
    Abstract: Disclosed herein are methods and kits for selectively amplifying, detecting or quantifying a DNA fragment with a specific end sequence, especially generated following restriction enzyme digestion. This method can be used, for example, to detect a hypomethylated DNA fragment. This methods and kits are especially useful in detecting or quantifying a hypomethylated fetal DNA fragment in a maternal plasma sample containing a corresponding hypermethylated maternal DNA fragment.
    Type: Grant
    Filed: April 29, 2014
    Date of Patent: June 25, 2019
    Assignee: The Chinese University of Hong Kong
    Inventors: Yuk Ming Dennis Lo, Yu Kwan Tong, Wai Kwun Rossa Chiu, Chunming Ding
  • MARKER FOR PRENATAL DIAGNOSIS AND MONITORING
    Publication number: 20180155791
    Abstract: The present invention relates to new methods for diagnosing a pregnancy-associated disorder by analyzing fetal DNA present in the mother's blood. More specifically, this invention relies on the discovery that the maspin gene is differentially methylated in fetal DNA and in maternal DNA and provides these new diagnostic methods, which distinguish fetal DNA from maternal DNA and detect prenatal disorders based on abnormalities in fetal DNA level and methylation status.
    Type: Application
    Filed: December 14, 2017
    Publication date: June 7, 2018
    Inventors: Yuk Ming Dennis LO, Rossa Wai Kwun Chiu, Stephen Siu Chung Chim, Yu-Kwan Tong, Chunming Ding
  • Marker for prenatal diagnosis and monitoring
    Patent number: 9862999
    Abstract: The present invention relates to new methods for diagnosing a pregnancy-associated disorder by analyzing fetal DNA present in the mother's blood. More specifically, this invention relies on the discovery that the maspin gene is differentially methylated in fetal DNA and in maternal DNA and provides these new diagnostic methods, which distinguish fetal DNA from maternal DNA and detect prenatal disorders based on abnormalities in fetal DNA level and methylation status.
    Type: Grant
    Filed: February 1, 2016
    Date of Patent: January 9, 2018
    Assignee: The Chinese University of Hong Kong
    Inventors: Yuk Ming Dennis Lo, Wai Kwun Rossa Chiu, Stephen Siu-Chung Chim, Yu-Kwan Tong, Chunming Ding
  • MARKER FOR PRENATAL DIAGNOSIS AND MONITORING
    Publication number: 20160258018
    Abstract: The present invention relates to new methods for diagnosing a pregnancy-associated disorder by analyzing fetal DNA present in the mother's blood. More specifically, this invention relies on the discovery that the maspin gene is differentially methylated in fetal DNA and in maternal DNA and provides these new diagnostic methods, which distinguish fetal DNA from maternal DNA and detect prenatal disorders based on abnormalities in fetal DNA level and methylation status.
    Type: Application
    Filed: February 1, 2016
    Publication date: September 8, 2016
    Inventors: Yuk Ming Dennis Lo, Wai Kwun Rossa Chiu, Stephen Siu-Chung Chim, Yu-Kwan Tong, Chunming Ding
  • METHODS AND KITS FOR SELECTIVELY AMPLIFYING, DETECTING OR QUANTIFYING TARGET DNA WITH SPECIFIC END SEQUENCES
    Publication number: 20140302506
    Abstract: Disclosed herein are methods and kits for selectively amplifying, detecting or quantifying a DNA fragment with a specific end sequence, especially generated following restriction enzyme digestion. This method can be used, for example, to detect a hypomethylated DNA fragment. This methods and kits are especially useful in detecting or quantifying a hypomethylated fetal DNA fragment in a maternal plasma sample containing a corresponding hypermethylated maternal DNA fragment.
    Type: Application
    Filed: April 29, 2014
    Publication date: October 9, 2014
    Applicant: The Chinese University of Hong Kong
    Inventors: Yuk Ming Dennis Lo, Yu Kwan Tong, Wai Kwun Rossa Chiu, Chunming Ding
  • Methods and kits for selectively amplifying, detecting or quantifying target DNA with specific end sequences
    Patent number: 8748100
    Abstract: Disclosed herein are methods and kits for selectively amplifying, detecting or quantifying a DNA fragment with a specific end sequence, especially generated following restriction enzyme digestion. This method can be used, for example, to detect a hypomethylated DNA fragment. This methods and kits are especially useful in detecting or quantifying a hypomethylated fetal DNA fragment in a maternal plasma sample containing a corresponding hypermethylated maternal DNA fragment.
    Type: Grant
    Filed: August 30, 2007
    Date of Patent: June 10, 2014
    Assignee: The Chinese University of Hong Kong
    Inventors: Yuk Ming Dennis Lo, Yu Kwan Tong, Wai Kwun Rossa Chiu, Chunming Ding
  • Method for detecting chromosomal aneuploidy
    Patent number: 8563242
    Abstract: The present invention relates to a new, non-invasive method for detecting chromosomal aneuploidy by analyzing a sample from a pregnant woman. The detection is based on the ratio between the amount of a fetal methylation marker located on a chromosome relevant to the aneuploidy and the amount of a fetal genetic marker located on a reference chromosome, offering improved accuracy.
    Type: Grant
    Filed: July 9, 2010
    Date of Patent: October 22, 2013
    Assignee: The Chinese University of Hong Kong
    Inventors: Yuk Ming Dennis Lo, Rossa Wai Kwun Chiu, Yu Kwan Tong, Shengnan Jin, Siu Chung Stephen Chim, Wai Yi Tsui
  • MARKER FOR PRENATAL DIAGNOSIS AND MONITORING
    Publication number: 20120003650
    Abstract: The present invention relates to new methods for diagnosing a pregnancy-associated disorder by analyzing fetal DNA present in the mother's blood. More specifically, this invention relies on the discovery that the maspin gene is differentially methylated in fetal DNA and in maternal DNA and provides these new diagnostic methods, which distinguish fetal DNA from maternal DNA and detect prenatal disorders based on abnormalities in fetal DNA level and methylation status.
    Type: Application
    Filed: August 22, 2011
    Publication date: January 5, 2012
    Applicant: The Chinese University of Hong Kong
    Inventors: Yuk Ming Dennis LO, Rossa Wai Kwun Chiu, Stephen Siu Chung Chim, Yu-Kwan Tong, Chunming Ding
  • Marker for prenatal diagnosis and monitoring
    Patent number: 8026067
    Abstract: The present invention relates to new methods for diagnosing a pregnancy-associated disorder by analyzing fetal DNA present in the mother's blood. More specifically, this invention relies on the discovery that the maspin gene is differentially methylated in fetal DNA and in maternal DNA and provides these new diagnostic methods, which distinguish fetal DNA from maternal DNA and detect prenatal disorders based on abnormalities in fetal DNA level and methylation status.
    Type: Grant
    Filed: March 15, 2010
    Date of Patent: September 27, 2011
    Assignee: The Chinese University of Hong Kong
    Inventors: Yuk Ming Dennis Lo, Rossa Wai Kwun Chiu, Stephen Siu Chung Chim, Yu-kwan Tong, Chunming Ding
  • METHOD FOR DETECTING CHROMOSOMAL ANEUPLOIDY
    Publication number: 20110039724
    Abstract: The present invention relates to a new, non-invasive method for detecting chromosomal aneuploidy by analyzing a sample from a pregnant woman. The detection is based on the ratio between the amount of a fetal methylation marker located on a chromosome relevant to the aneuploidy and the amount of a fetal genetic marker located on a reference chromosome, offering improved accuracy.
    Type: Application
    Filed: July 9, 2010
    Publication date: February 17, 2011
    Applicant: The Chinese University of Hong Kong
    Inventors: Yuk Ming Dennis Lo, Rossa Wai Kwun Chiu, Yu Kwan Tong, Shengnan Jin, Siu Chung Stephen Chim, Wai Yi Tsui
  • Marker for Prenatal Diagnosis and Monitoring
    Publication number: 20100323352
    Abstract: The present invention relates to new methods for diagnosing a pregnancy-associated disorder by analyzing fetal DNA present in the mother's blood. More specifically, this invention relies on the discovery that the maspin gene is differentially methylated in fetal DNA and in maternal DNA and provides these new diagnostic methods, which distinguish fetal DNA from maternal DNA and detect prenatal disorders based on abnormalities in fetal DNA level and methylation status.
    Type: Application
    Filed: March 15, 2010
    Publication date: December 23, 2010
    Applicant: THE CHINESE UNIVERSITY OF HONG KONG
    Inventors: YUK MING DENNIS LO, ROSSA WAI KWUN CHIU, STEPHEN SIU CHUNG CHIM, YU-KWAN TONG, CHUNMING DING
  • Marker for prenatal diagnosis and monitoring
    Patent number: 7709194
    Abstract: The present invention relates to new methods for diagnosing a pregnancy-associated disorder by analyzing fetal DNA present in the mother's blood. More specifically, this invention relies on the discovery that the maspin gene is differentially methylated in fetal DNA and in maternal DNA and provides these new diagnostic methods, which distinguish fetal DNA from maternal DNA and detect prenatal disorders based on abnormalities in fetal DNA level and methylation status.
    Type: Grant
    Filed: June 3, 2005
    Date of Patent: May 4, 2010
    Assignee: The Chinese University of Hong Kong
    Inventors: Yuk Ming Dennis Lo, Rossa Wai Kwun Chiu, Stephen Siu Chung Chim, Yu-kwan Tong, Chunming Ding
  • Methods and kits for selectively amplifying, detecting or quantifying target DNA with specific end sequences
    Publication number: 20090061425
    Abstract: Disclosed herein are methods and kits for selectively amplifying, detecting or quantifying a DNA fragment with a specific end sequence, especially generated following restriction enzyme digestion. This method can be used, for example, to detect a hypomethylated DNA fragment. This methods and kits are especially useful in detecting or quantifying a hypomethylated fetal DNA fragment in a maternal plasma sample containing a corresponding hypermethylated maternal DNA fragment.
    Type: Application
    Filed: August 30, 2007
    Publication date: March 5, 2009
    Applicant: The Chinese University of Hong Kong
    Inventors: Yuk Ming Dennis Lo, Yu Kwan Tong, Wai Kwun Rossa Chiu, Chunming Ding
  • Marker for prenatal diagnosis and monitoring
    Publication number: 20060019278
    Abstract: The present invention relates to new methods for diagnosing a pregnancy-associated disorder by analyzing fetal DNA present in the mother's blood. More specifically, this invention relies on the discovery that the maspin gene is differentially methylated in fetal DNA and in maternal DNA and provides these new diagnostic methods, which distinguish fetal DNA from maternal DNA and detect prenatal disorders based on abnormalities in fetal DNA level and methylation status.
    Type: Application
    Filed: June 3, 2005
    Publication date: January 26, 2006
    Applicant: The Chinese University of Hong Kong
    Inventors: Yuk Ming Lo, Rossa Chiu, Stephen Chim, Yu-kwan Tong, Chunming Ding