Abstract: The present invention pertains to a method for culturing cord blood-derived natural killer cells using transformed T-cells. The method for culturing natural killer cells using transformed T-cells according to the present invention can effectively propagate and produce natural killer cells from a small amount of raw cells. In addition, the method can also improve the cell-killing ability of natural killer cells. Thus, the method for culturing natural killer cells using transformed T-cells according to the present invention can be usefully used to commercialize cell therapeutic agents. Moreover, natural killer cells produced by the culturing method of the present invention can be usefully used as a cell therapeutic agent.

Abstract: Provided is a method of extracting a mediator variable and a mediation influence from a multivariate set. The method includes: receiving a database in which a set of N multiple variables (N is a natural number) including at least one of discrete time series data or continuous time series data is stored; selecting a test variable set including an independent variable, a dependent variable, and a mediator variable from the database in which the multivariate set is stored; determining the mediator variable using transfer entropy and conditional transfer entropy for the selected test variable set; and calculating a mediation influence of the determined mediator variable, wherein the mediation influence is separately calculated as an individual causal influence of the mediator variable and a group causal influence of mediator variables.

Abstract: Provided is a method of extracting a mediator variable and a mediation influence from a multivariate set. The method includes: receiving a database in which a set of N multiple variables (N is a natural number) including at least one of discrete time series data or continuous time series data is stored; selecting a test variable set including an independent variable, a dependent variable, and a mediator variable from the database in which the multivariate set is stored; determining the mediator variable using transfer entropy and conditional transfer entropy for the selected test variable set; and calculating a mediation influence of the determined mediator variable, wherein the mediation influence is separately calculated as an individual causal influence of the mediator variable and a group causal influence of mediator variables.