Patents by Inventor Yuanli Song

Yuanli Song has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FLOCCULATION AAV PURIFICATION
    Publication number: 20240158761
    Abstract: The disclosure provides methods of purifying adeno-associated virus (AAV) particles by introducing a flocculant step into a large scale a manufacturing process, thereby improving AAV particle purity and yield.
    Type: Application
    Filed: November 16, 2023
    Publication date: May 16, 2024
    Applicant: Genzyme Corporation
    Inventors: Bruno Figueroa, Qingxuan Li, Junfen Ma, Yuanli Song
  • METHOD FOR PURIFYING PEGYLATED PROTEIN
    Publication number: 20220017570
    Abstract: This disclosure provides a novel method of purifying PEGylated proteins using ion exchange chromatography by loading PEGylated protein having a high concentration, e.g., at least 6 grams/liter on an ion exchange chromatography matrix, and collecting the PEGylated protein.
    Type: Application
    Filed: November 4, 2019
    Publication date: January 20, 2022
    Inventors: Deqiang YU, John PAGANO, Hasin FEROZ, Yuanli SONG, Sanchayita GHOSE, Zhengjian LI
  • METHODS OF PURIFYING MONOMERIC MONOCLONAL ANTIBODIES
    Publication number: 20210009632
    Abstract: In certain embodiments, the present invention provides a method of purifying a monomeric monoclonal antibody from a mixture which comprises the monomeric monoclonal antibody and one or more contaminants, comprising: a) subjecting the mixture to cation exchange chromatography (CEX) matrix, wherein the monomeric monoclonal antibody binds to the CEX matrix; b) contacting the CEX matrix with a wash solution at a pH which is between about 7 and about 7.8; c) eluting the monomeric monoclonal antibody from the CEX matrix into an elution solution, thereby purifying the monomeric monoclonal antibody.
    Type: Application
    Filed: March 28, 2019
    Publication date: January 14, 2021
    Inventors: Zhijun Tan, Vivekh Ehamparanathan, Yuanli Song, Angela T. Lewandowski, Zhengjian Li