Patents by Inventor Yuanpei Li
Yuanpei Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230372534Abstract: The present inventions provides drug-drug conjugates, drug-porphyrin conjugates, nanoparticles of the conjugates, as well as modified nanoparticles having PEGylated exteriors or encapsulated by red blood cell vesicles. The conjugates, nanoparticles and nanocarriers are useful for treating cancers and other diseases, as well as for imaging diseased tissue or organs.Type: ApplicationFiled: November 8, 2022Publication date: November 23, 2023Inventors: Yuanpei LI, Xiangdong XUE, Yee HUANG, Zhao MA
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Publication number: 20230348419Abstract: The present invention provides bisaminoquinoline compounds of Formula (I). The present invention also provides nanocarriers comprising compounds of the present invention, and methods of using the nanocarriers for treating diseases and imaging.Type: ApplicationFiled: September 18, 2020Publication date: November 2, 2023Inventors: Yuanpei LI, Zhao MA
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Publication number: 20230076792Abstract: The present invention provides a compound of Formula (I) as defined herein. The present invention also provides a nanoparticle comprising a plurality of the conjugates of the present invention, and methods of using the nanoparticles for drug delivery, treating a disease, and methods of imaging.Type: ApplicationFiled: December 16, 2020Publication date: March 9, 2023Inventors: Yuanpei LI, Hao WU, Tzu-yin LIN
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Patent number: 11559585Abstract: The present inventions provides drug-drug conjugates, drug-porphyrin conjugates, nanoparticles of the conjugates, as well as modified nanoparticles having PEGylated exteriors or encapsulated by red blood cell vesicles. The conjugates, nanoparticles and nanocarriers are useful for treating cancers and other diseases, as well as for imaging diseased tissue or organs.Type: GrantFiled: June 15, 2018Date of Patent: January 24, 2023Assignee: The Regents of the University of CaliforniaInventors: Yuanpei Li, Xiangdong Xue, Yee Huang, Zhao Ma
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Patent number: 11369688Abstract: Methods and compositions are provided for hybrid telodendrimers and nanocarriers containing such hybrid telodendrimers.Type: GrantFiled: September 15, 2017Date of Patent: June 28, 2022Assignee: The Regents of the University of CaliforniaInventors: Kit S. Lam, Yuanpei Li, Gaurav Bharadwaj
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Patent number: 11219692Abstract: The present invention provides amphiphilic telodendrimers that aggregate to form nanocarriers characterized by a hydrophobic core and a hydrophilic exterior. The nanocarrier core may include amphiphilic functionality such as cholic acid or cholic acid derivatives, and the exterior may include branched or linear poly(ethylene glycol) segments. Nanocarrier cargo such as hydrophobic drugs and other materials may be sequester in the core via non-covalent means or may be covalently bound to the telodendrimer building blocks. Telodendrimer structure may be tailored to alter loading properties, interactions with materials such as biological membranes, and other characteristics.Type: GrantFiled: March 15, 2019Date of Patent: January 11, 2022Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Kit S. Lam, Yuanpei Li, Chong-Xian Pan
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Patent number: 11192978Abstract: The present invention provides amphiphilic telodendrimers that aggregate to form nanocarriers characterized by a hydrophobic core and a hydrophilic exterior. The nanocarrier core may include amphiphilic functionality such as cholic acid or cholic acid derivatives, and the exterior may include branched or linear poly(ethylene glycol) segments. Nanocarrier cargo such as hydrophobic drugs and other materials may be sequester in the core via non-covalent means or may be covalently bound to the telodendrimer building blocks. Telodendrimer structure may be tailored to alter loading properties, interactions with materials such as biological membranes, and other characteristics.Type: GrantFiled: September 14, 2018Date of Patent: December 7, 2021Assignee: The Regents of the University of CaliforniaInventors: Kit S. Lam, Yuanpei Li, Juntao Luo, Kai Xiao
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Patent number: 11135309Abstract: The present invention provides a nanoparticle including at least one poly(vinyl alcohol) (PVA) having a molecular weight of from about 10 kDa to about 200 kDa, substituted with one or more moieties selected from: a therapeutic agent having a boronic acid moiety, wherein the therapeutic agent is covalently linked to the PVA via a boronate ester bond; a crosslinking group having a disulfide moiety, wherein the crosslinking group is covalently linked to the PVA, and a porphyrin, wherein the porphyrin is covalently linked to the PVA. Use of the nanoparticles for tumor detection and the treatment of diseases, including methods for photodynamic therapy and photothermal therapy, are also described.Type: GrantFiled: August 15, 2016Date of Patent: October 5, 2021Assignee: The Regents of the University of CaliforniaInventors: Kit S. Lam, Yuanpei Li, Kai Xiao, Caihong Feng
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Publication number: 20210138084Abstract: The present inventions provides drug-drug conjugates, drug-porphyrin conjugates, nanoparticles of the conjugates, as well as modified nanoparticles having PEGylated exteriors or encapsulated by red blood cell vesicles. The conjugates, nanoparticles and nanocarriers are useful for treating cancers and other diseases, as well as for imaging diseased tissue or organs.Type: ApplicationFiled: June 15, 2018Publication date: May 13, 2021Inventors: Yuanpei LI, Xiangdong XUE, Yee HUANG, Zhao MA
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Publication number: 20200046841Abstract: The present invention provides amphiphilic telodendrimers that aggregate to form nanocarriers characterized by a hydrophobic core and a hydrophilic exterior. The nanocarrier core may include amphiphilic functionality such as cholic acid or cholic acid derivatives, and the exterior may include branched or linear poly(ethylene glycol) segments. Nanocarrier cargo such as hydrophobic drugs and other materials may be sequester in the core via non-covalent means or may be covalently bound to the telodendrimer building blocks. Telodendrimer structure may be tailored to alter loading properties, interactions with materials such as biological membranes, and other characteristics.Type: ApplicationFiled: March 15, 2019Publication date: February 13, 2020Inventors: Kit S. LAM, Yuanpei LI, Chong-Xian PAN
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Publication number: 20190358338Abstract: Methods and compositions are provided for hybrid telodendrimers and nanocarriers containing such hybrid telodendrimers.Type: ApplicationFiled: September 15, 2017Publication date: November 28, 2019Inventors: Kit S. LAM, Yuanpei LI, Guarav BHARADWAJ
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Publication number: 20190112423Abstract: The present invention provides amphiphilic telodendrimers that aggregate to form nanocarriers characterized by a hydrophobic core and a hydrophilic exterior. The nanocarrier core may include amphiphilic functionality such as cholic acid or cholic acid derivatives, and the exterior may include branched or linear poly(ethylene glycol) segments. Nanocarrier cargo such as hydrophobic drugs and other materials may be sequester in the core via non-covalent means or may be covalently bound to the telodendrimer building blocks. Telodendrimer structure may be tailored to alter loading properties, interactions with materials such as biological membranes, and other characteristics.Type: ApplicationFiled: September 14, 2018Publication date: April 18, 2019Inventors: Kit S. Lam, Yuanpei Li, Juntao Luo, Kai Xiao
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Patent number: 10238750Abstract: The present invention provides amphiphilic telodendrimers that aggregate to form nanocarriers characterized by a hydrophobic core and a hydrophilic exterior. The nanocarrier core may include amphiphilic functionality such as cholic acid or cholic acid derivatives, and the exterior may include branched or linear poly(ethylene glycol) segments. Nanocarrier cargo such as hydrophobic drugs and other materials may be sequester in the core via non-covalent means or may be covalently bound to the telodendrimer building blocks. Telodendrimer structure may be tailored to alter loading properties, interactions with materials such as biological membranes, and other characteristics.Type: GrantFiled: December 12, 2013Date of Patent: March 26, 2019Assignee: The Regents of the University of CaliforniaInventors: Kit Lam, Yuanpei Li, Chongxian Pan
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Patent number: 10106650Abstract: The present invention provides amphiphilic telodendrimers that aggregate to form nanocarriers characterized by a hydrophobic core and a hydrophilic exterior. The nanocarrier core may include amphiphilic functionality such as cholic acid or cholic acid derivatives, and the exterior may include branched or linear poly(ethylene glycol) segments. Nanocarrier cargo such as hydrophobic drugs and other materials may be sequester in the core via non-covalent means or may be covalently bound to the telodendrimer building blocks. Telodendrimer structure may be tailored to alter loading properties, interactions with materials such as biological membranes, and other characteristics.Type: GrantFiled: May 14, 2012Date of Patent: October 23, 2018Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Kit S. Lam, Yuanpei Li, Juntao Luo, Kai Xiao
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Publication number: 20180243442Abstract: The present invention provides a nanoparticle including at least one polyvinyl alcohol) (PVA) having a molecular weight of from about 10 kDa to about 200 kDa, substituted with one or more moieties selected from: a therapeutic agent having a boronic acid moiety, wherein the therapeutic agent is covalently linked to the PVA via a boronate ester bond; a crosslinking group having a disulfide moiety, wherein the crosslinking group is covalently linked to the PVA, and a porphyrin, wherein the porphyrin is covalently linked to the PVA. Use of the nanoparticles for tumor detection and the treatment of diseases, including methods for photodynamic therapy and photothermal therapy, are also described.Type: ApplicationFiled: August 15, 2016Publication date: August 30, 2018Inventors: KIT S. LAM, YUANPEI LI, KAI XIAO, CAIHONG FENG
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Publication number: 20180078652Abstract: Methods and compositions are provided for treating a vascular abnormality.Type: ApplicationFiled: April 22, 2016Publication date: March 22, 2018Inventors: Hakan ORBAY, David SAHAR, Yuanpei LI, Kit S. LAM
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Publication number: 20180036417Abstract: The present invention provides amphiphilic telodendrimers that aggregate to form nanocarriers characterized by a hydrophobic core and a hydrophilic exterior. The nanocarrier core may include amphiphilic functionality such as cholic acid or cholic acid derivatives, and the exterior may include branched or linear poly(ethylene glycol) segments. Nanocarrier cargo such as hydrophobic drugs and other materials may be sequester in the core via non-covalent means or may be covalently bound to the telodendrimer building blocks. Telodendrimer structure may be tailored to alter loading properties, interactions with materials such as biological membranes, and other characteristics.Type: ApplicationFiled: March 24, 2017Publication date: February 8, 2018Inventors: Kit S. LAM, Yuanpei LI, Chong-Xian PAN, Tzu-yin LIN
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Patent number: 9642916Abstract: The present invention provides amphiphilic telodendrimers that aggregate to form nanocarriers characterized by a hydrophobic core and a hydrophilic exterior. The nanocarrier core may include amphiphilic functionality such as cholic acid or cholic acid derivatives, and the exterior may include branched or linear poly(ethylene glycol) segments. Nanocarrier cargo such as hydrophobic drugs and other materials may be sequester in the core via non-covalent means or may be covalently bound to the telodendrimer building blocks. Telodendrimer structure may be tailored to alter loading properties, interactions with materials such as biological membranes, and other characteristics.Type: GrantFiled: March 14, 2013Date of Patent: May 9, 2017Assignee: The Regents of the University of CaliforniaInventors: Kit S. Lam, Yuanpei Li, Chong-Xian Pan, Tzu-yin Lin
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Publication number: 20160038605Abstract: The present invention provides amphiphilic telodendrimers that aggregate to form nanocarriers characterized by a hydrophobic core and a hydrophilic exterior. The nanocarrier core may include amphiphilic functionality such as cholic acid or cholic acid derivatives, and the exterior may include branched or linear poly(ethylene glycol) segments. Nanocarrier cargo such as hydrophobic drugs and other materials may be sequester in the core via non-covalent means or may be covalently bound to the telodendrimer building blocks. Telodendrimer structure may be tailored to alter loading properties, interactions with materials such as biological membranes, and other characteristics.Type: ApplicationFiled: December 12, 2013Publication date: February 11, 2016Inventors: Kit Lam, Yuanpei Li, Chongxian Pan
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Publication number: 20150045419Abstract: The present invention provides amphiphilic telodendrimers that aggregate to form nanocarriers characterized by a hydrophobic core and a hydrophilic exterior. The nanocarrier core may include amphiphilic functionality such as cholic acid or cholic acid derivatives, and the exterior may include branched or linear poly(ethylene glycol) segments. Nanocarrier cargo such as hydrophobic drugs and other materials may be sequester in the core via non-covalent means or may be covalently bound to the telodendrimer building blocks. Telodendrimer structure may be tailored to alter loading properties, interactions with materials such as biological membranes, and other characteristics.Type: ApplicationFiled: May 14, 2012Publication date: February 12, 2015Applicant: The Regents of the University of CaliforniaInventors: Kit S. Lam, Yuanpei Li