Patents by Inventor Yudan YIN
Yudan YIN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11913947Abstract: The present disclosure provides a digital immunochip and a manufacture method thereof. The digital immunochip includes a first substrate and a second substrate which are opposite to each other. The first substrate includes: a first base substrate; at least one driving electrode on the first base substrate and configured to drive an object to be detected to move; a dielectric layer on a side of the at least one driving electrode away from the first base substrate and covering the at least one driving electrode; and a first hydrophobic layer on a side of the dielectric layer away from the first base substrate. The second substrate includes: a second base substrate; and an immunoassay substance on a side of the second base substrate proximal to the first hydrophobic layer of the first substrate and including an antigen or an antibody.Type: GrantFiled: June 23, 2021Date of Patent: February 27, 2024Assignee: BOE TECHNOLOGY GROUP CO., LTD.Inventors: Haonan Liu, Yudan Yin, Ding Ding
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Patent number: 11904316Abstract: The present disclosure provides a microfluidic chip, including: a support and an NFC coil in the support, and a flow path is provided in the support and is isolated from the NFC coil; the flow path includes at least one detection window region with a stationary phase therein, and the stationary phase is used to specifically capture a target analyte, the detection window region at least partially overlaps with the NFC coil in a thickness direction of the support. The present disclosure further provides a detection method of the microfluidic chip and a micro total analysis system. The present disclosure can quickly and immediately obtain a detection result.Type: GrantFiled: May 15, 2020Date of Patent: February 20, 2024Assignee: BOE TECHNOLOGY GROUP CO., LTD.Inventor: Yudan Yin
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Patent number: 11883822Abstract: A reaction device for a detection chip and a reaction system are provided. The reaction device includes a chip carrier and an electrical signal control unit. The chip carrier is configured to place and fix the detection chip; and the electrical signal control unit is configured to apply an electrical signal to the detection chip so as to drive a heating electrode of the detection chip.Type: GrantFiled: March 31, 2020Date of Patent: January 30, 2024Assignees: BEIJING BOE TECHNOLOGY DEVELOPMENT CO., LTD., BOE TECHNOLOGY GROUP CO., LTD.Inventors: Zijian Zhao, Mengjun Hou, Yudan Yin
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Publication number: 20230191394Abstract: A detection chip, a using method for the same, and a reaction system. The detection chip includes a first substrate, a micro-cavity defining layer, and a heating electrode. The micro-cavity defining layer is on the first substrate and defines a plurality of micro-reaction chambers. The heating electrode is on the first substrate and is closer to the first substrate than the micro-cavity defining layer, and is configured to heat a plurality of micro-reaction chambers. The orthographic projection of the plurality of micro-reaction chambers on the first substrate is within the orthographic projection of the heating electrode on the first substrate.Type: ApplicationFiled: February 22, 2023Publication date: June 22, 2023Inventors: Zhihong WU, Zijian ZHAO, Yudan YIN, Mengjun HOU, Kang PENG
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Publication number: 20230176045Abstract: The present disclosure provides microfluidic flow channel structure, detection system and method for using detection system, aiming at improving uniformity of liquid introduction of microfluidic detection system. Microfluidic flow channel structure includes liquid inlet section (1), main chamber (3) and liquid outlet section (2), main chamber (3) includes liquid inlet end (31), chamber middle part (33) and liquid outlet end (32); liquid inlet section (1), liquid inlet end (31), chamber middle part (33), liquid outlet end (32) and liquid outlet section (2) are sequentially connected together; width of liquid inlet end (31) is gradually increased in direction from liquid inlet section (1) to chamber middle part (33); thinning flow guidance region (310) is provided at edge of liquid inlet end (31) formed as width of liquid inlet end varies, and has thickness less than that of remaining region except thinning flow guidance region (310) of main chamber (3).Type: ApplicationFiled: May 12, 2021Publication date: June 8, 2023Inventors: Yudan YIN, Jing YU, Haonan LIU, Zhukai LIU
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Patent number: 11654435Abstract: The detection chip includes a first substrate, a micro-cavity defining layer, a hydrophilic layer, and a hydrophobic layer. The micro-cavity defining layer is on the first substrate and defines a plurality of micro-reaction chambers. Each of the plurality of micro-reaction chambers includes a reaction trap, and the reaction trap includes a sidewall and a bottom. The micro-cavity defining layer includes a spacing region between the plurality of micro-reaction chambers, and the spacing region includes a first region adjacent to the sidewall, and a second region non-adjacent to the sidewall. The hydrophilic layer covers the sidewall and the bottom of each of the plurality of micro-reaction chambers, and the hydrophobic layer covers the second region.Type: GrantFiled: March 29, 2019Date of Patent: May 23, 2023Assignee: BOE TECHNOLOGY GROUP CO., LTD.Inventors: Zijian Zhao, Siyi Yin, Yudan Yin
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Publication number: 20230137571Abstract: The present disclosure relates to a microfluidic chip. The microfluidic chip includes a first substrate, and the first substrate includes a sample input hole and a reaction region located downstream of the sample input hole. The reaction region includes at least one groove, an orthographic projection of each groove on the first substrate is an axisymmetric pattern, a width of the axisymmetric pattern in a first direction is not less than a width of the axisymmetric pattern in a second direction, and the first direction is perpendicular to the second direction.Type: ApplicationFiled: February 5, 2021Publication date: May 4, 2023Inventors: Haonan LIU, Yudan YIN, Ding DING
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Patent number: 11607682Abstract: A detection chip, a using method for the same, and a reaction system. The detection chip includes a first substrate, a micro-cavity defining layer, and a heating electrode. The micro-cavity defining layer is on the first substrate and defines a plurality of micro-reaction chambers. The heating electrode is on the first substrate and is closer to the first substrate than the micro-cavity defining layer, and is configured to heat a plurality of micro-reaction chambers. The orthographic projection of the plurality of micro-reaction chambers on the first substrate is within the orthographic projection of the heating electrode on the first substrate.Type: GrantFiled: March 29, 2019Date of Patent: March 21, 2023Assignee: BEIJING BOE TECHNOLOGY DEVELOPMENT CO., LTD.Inventors: Zhihong Wu, Zijian Zhao, Yudan Yin, Mengjun Hou, Kang Peng
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Patent number: 11591370Abstract: A peptoid compound, a manufacturing method of a peptoid compound, an oligomer, a pharmaceutical composition, use of the pharmaceutical composition in the preparation of a medicament for detecting or diagnosing a disease related to tyrosine kinase HER2, and a kit for identifying circulating tumor cells are provided, the peptoid compound includes: a cysteine (Cys) subunit, a butanediamine (Nlys) subunit, a 3,4-methylenedioxybenzylamine (Npip) subunit, a 3-aminopropanic acid (Nce) subunit and a 1-naphthylamine (Na) subunit, and both the peptoid compound and the oligomer have a strong ability to bind to HER2 protein on surfaces of circulating tumor cells (CTCs), and a technology of diagnosing breast cancer on the basis of the peptoid compound can realize non-invasive and label-free rapid diagnosis, in addition, the methods for synthesizing the peptoid compound and the oligomer are simple, the preparation efficiency is high, and the production cost is low.Type: GrantFiled: August 22, 2019Date of Patent: February 28, 2023Assignees: BEIJING BOE TECHNOLOGY DEVELOPMENT CO., LTD., BOE TECHNOLOGY GROUP CO., LTD.Inventors: Zijian Zhao, Yudan Yin
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Patent number: 11559476Abstract: The present application provides a method for preparing a hydrogel and the obtained hydrogel. The method including: forming a first part by mixing a first single-stranded nucleotide with a first liposome, and forming a second part by mixing a second single-stranded nucleotide with a second liposome, wherein the first single-stranded nucleotide and the second single-stranded nucleotide have complementary sticky ends; forming a hydrogel by mixing the first part and the second part.Type: GrantFiled: June 26, 2020Date of Patent: January 24, 2023Assignee: BOE TECHNOLOGY GROUP CO., LTD.Inventor: Yudan Yin
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Publication number: 20220411732Abstract: Disclosed are a detection chip and a manufacturing method therefor, and a reaction system. The detection chip includes: a first substrate (11); a microcavity defining layer (12), which is located on the first substrate (11) and defines a plurality of micro-reaction chambers (120); and a shading structure layer (13), which is located on the first substrate (11) and provided among the plurality of micro-reaction chambers (120). In practical application, the number of target molecules in a reaction system solution in each micro-reaction chamber (120) can be determined by collecting a fluorescence image; and the detection chip is provided with the shading structure layer (13), and the shading structure layer (13) is located on the first substrate (11) and provided among the plurality of micro-reaction chambers (120).Type: ApplicationFiled: January 14, 2021Publication date: December 29, 2022Inventors: Mengjun HOU, Zijian ZHAO, Yudan YIN, Zongmin LIU, Liye DUAN
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Publication number: 20220317116Abstract: A quality detection method of an immunochip is disclosed. At least part of a surface of the immunochip is a modified surface with modifying groups. The method comprises: applying a detection solution containing a labeled antibody on the modified surface of the immunochip, the labeled antibody is an antibody connected with a labeling substance, and the labeled antibody is capable of reacting with the modifying groups and bonding to the modifying groups; removing the labeled antibody that has not reacted with the modifying groups, and detecting the content of residual labeled antibody on the modified surface; and identifying the quality of the immunochip according to the content of residual labeled antibody.Type: ApplicationFiled: February 23, 2021Publication date: October 6, 2022Inventors: Haonan LIU, Yudan YIN
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Publication number: 20220274105Abstract: Disclosed are a detection chip and a modification method therefor. The modification method includes performing a surface activation treatment on a hydrophilic layer of the detection chip, such that a hydroxy-containing modification group is formed on a surface of the hydrophilic layer; then performing a surface amination treatment on the hydrophilic layer using a solution containing an amino compound, such that an amino-containing modification group is formed on the surface of the hydrophilic layer, and performing a surface carboxylation treatment on the hydrophilic layer using a solution containing an anhydride compound, such that a carboxyl-containing modification group is formed on the surface of the hydrophilic layer.Type: ApplicationFiled: March 3, 2021Publication date: September 1, 2022Inventors: Yudan YIN, Jing YU, Haonan LIU, Zhukai LIU
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Publication number: 20220274106Abstract: Disclosed are a detection chip and a modification method therefor. A surface activation treatment is performed on a hydrophilic layer of the detection chip, such that a hydroxy-containing modification group is formed on a surface of the hydrophilic layer; and a solution containing an oxy compound is then used to perform a surface epoxidation treatment on the hydrophilic layer in order to form an epoxy-containing modification group on the surface of the hydrophilic layer.Type: ApplicationFiled: March 3, 2021Publication date: September 1, 2022Inventors: Yudan YIN, Jing YU, Haonan LIU, Zhukai LIU
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Publication number: 20220274107Abstract: Disclosed are a detection chip and a modification method therefor. The method for modifying the detection chip comprises performing a surface film-forming treatment on a hydrophilic layer on a first substrate constituting the detection chip to form polydopamine film on a surface of the hydrophilic layer; and adopting a buffer solution containing sodium hyaluronate to perform a surface carboxylation treatment on the hydrophilic layer, on the surface of which the polydopamine film has been formed, in order to form a carboxyl-containing modification group on the surface of the hydrophilic layer.Type: ApplicationFiled: March 4, 2021Publication date: September 1, 2022Inventors: Yudan YIN, Jing YU, Haonan LIU, Zhukai LIU
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Publication number: 20220258163Abstract: A microfluidic particle sorting apparatus for capturing targets from fluid containing the targets is disclosed. The apparatus includes an inlet for receiving the fluid; a sorting chamber allowing the fluid to flow through; a first outlet for discharging the fluid after flowing through the sorting chamber; a capturing structure for capturing the cells, wherein the capturing structure is upstream of the first outlet, and includes obstacles in an array, each extending through the sorting chamber in a lateral direction with respect to a fluid flow of the fluid; and a second outlet upstream of the capturing structure comprising a plurality of openings; wherein a gap between two adjacent obstacles is equal to or greater than each opening of the second outlet.Type: ApplicationFiled: May 4, 2022Publication date: August 18, 2022Applicant: BOE TECHNOLOGY GROUP CO., LTD.Inventors: Zhihong WU, Defeng MAO, Zijian ZHAO, Yudan YIN
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Publication number: 20220163516Abstract: The present disclosure provides a digital immunochip and a manufacture method thereof. The digital immunochip includes a first substrate and a second substrate which are opposite to each other. The first substrate includes: a first base substrate; at least one driving electrode on the first base substrate and configured to drive an object to be detected to move; a dielectric layer on a side of the at least one driving electrode away from the first base substrate and covering the at least one driving electrode; and a first hydrophobic layer on a side of the dielectric layer away from the first base substrate. The second substrate includes: a second base substrate; and an immunoassay substance on a side of the second base substrate proximal to the first hydrophobic layer of the first substrate and including an antigen or an antibody.Type: ApplicationFiled: June 23, 2021Publication date: May 26, 2022Inventors: Haonan LIU, Yudan YIN, Ding DING
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Patent number: 11338292Abstract: A microfluidic particle sorting apparatus for capturing targets from fluid containing the targets is disclosed. The apparatus includes an inlet for receiving the fluid; a sorting chamber allowing the fluid to flow through; a first outlet for discharging the fluid after flowing through the sorting chamber; a capturing structure for capturing the cells, wherein the capturing structure is upstream of the first outlet, and includes obstacles in an array, each extending through the sorting chamber in a lateral direction with respect to a fluid flow of the fluid; and a second outlet upstream of the capturing structure comprising a plurality of openings; wherein a gap between two adjacent obstacles is equal to or greater than each opening of the second outlet.Type: GrantFiled: March 12, 2019Date of Patent: May 24, 2022Assignee: BOE Technology Group Co., Ltd.Inventors: Zhihong Wu, Defeng Mao, Zijian Zhao, Yudan Yin
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Publication number: 20220050100Abstract: A detection chip and a method of manufacturing a detection chip are disclosed. The detection chip includes a first substrate, a plurality of detection units, and at least one diversion dam. The plurality of detection units are located on the first substrate, the diversion dam is located on the first substrate, and the diversion dam extends along a first path and is located between adjacent detection units.Type: ApplicationFiled: June 17, 2019Publication date: February 17, 2022Inventor: Yudan YIN
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Publication number: 20210354141Abstract: A microfluidic particle sorting apparatus for capturing targets from fluid containing the targets is disclosed. The apparatus includes an inlet for receiving the fluid; a sorting chamber allowing the fluid to flow through; a first outlet for discharging the fluid after flowing through the sorting chamber; a capturing structure for capturing the cells, wherein the capturing structure is upstream of the first outlet, and includes obstacles in an array, each extending through the sorting chamber in a lateral direction with respect to a fluid flow of the fluid; and a second outlet upstream of the capturing structure comprising a plurality of openings; wherein a gap between two adjacent obstacles is equal to or greater than each opening of the second outlet.Type: ApplicationFiled: March 12, 2019Publication date: November 18, 2021Applicant: BOE TECHNOLOGY GROUP CO., LTD.Inventors: Zhihong WU, Defeng MAO, Zijian ZHAO, Yudan YIN