Abstract: The present disclosure discloses an automobile wheel hub shaping device. The automobile wheel hub shaping device includes a clamping part for clamping a wheel hub to be shaped, a first driving mechanism for driving the clamping part to rotate, a shaping roller for shaping the wheel hub to be shaped, and a rack; all the clamping part, the first driving mechanism and the shaping roller are mounted to the rack, the shaping roller is located above the clamping part and is capable of rotating relative to the clamping part; and the clamping part is equipped with a fixing part for fixing the wheel hub to be shaped.

Abstract: Systems, methods, compositions, apparatuses, and kits for determining the 30-day mortality risk of subjects with viral infections, and for determining effective triage strategies for such subjects, are provided herein. The disclosed methods and compositions involve biomarkers identified from the application of a machine learning workflow to viral mortality training data. The biomarkers allow the calculation of a score that can be used to determine the likelihood of 30-day survival in the subjects.

Abstract: A spraying tooling of a motor vehicle wheel hub is provided. The spraying tooling includes an assembly line, multiple wheel hub bases each capable of moving on the assembly line, multiple driving mechanisms each capable of driving a wheel hub base to rotate at a preset position on the assembly line, multiple triggering components each capable of triggering a driving mechanism to operate, multiple maintaining components each capable of maintaining a preset time for a triggering component, and a control component; the wheel hub base includes a sliding seat capable of moving on the assembly line and a tray capable of rotating along with rotation of the driving mechanism, and the tray is rotatably mounted on the sliding seat; and all of the driving mechanisms and the triggering components are electrically connected to the control component.

Abstract: A wheel hub molding and casting die includes: a casting die shell, a supporting bottom plate, a limiting bottom plate, a lifting module, a module supporting plate, a lower die, an upper die and removable plates. The supporting bottom plate is mounted on the lower surface of the casting die shell. The limiting bottom plate is arranged below the supporting bottom plate. The module supporting plate is movably arranged in a molding cavity. The lifting module is connected between the bottom of the molding cavity and the module supporting plate. The lower die and the upper die are closed to form a pouring cavity. Annular slots are formed in the outer side wall of the upper die. Removable plate slots are formed in the upper surface of the casting die shell.

Abstract: A spraying tooling of a motor vehicle wheel hub is provided. The spraying tooling includes an assembly line, multiple wheel hub bases each capable of moving on the assembly line, multiple driving mechanisms each capable of driving a wheel hub base to rotate at a preset position on the assembly line, multiple triggering components each capable of triggering a driving mechanism to operate, multiple maintaining components each capable of maintaining a preset time for a triggering component, and a control component; the wheel hub base includes a sliding seat capable of moving on the assembly line and a tray capable of rotating along with rotation of the driving mechanism, and the tray is rotatably mounted on the sliding seat; and all of the driving mechanisms and the triggering components are electrically connected to the control component.

Abstract: The present disclosure discloses an automobile wheel hub shaping device. The automobile wheel hub shaping device includes a clamping part for clamping a wheel hub to be shaped, a first driving mechanism for driving the clamping part to rotate, a shaping roller for shaping the wheel hub to be shaped, and a rack; all the clamping part, the first driving mechanism and the shaping roller are mounted to the rack, the shaping roller is located above the clamping part and is capable of rotating relative to the clamping part; and the clamping part is equipped with a fixing part for fixing the wheel hub to be shaped.

Abstract: The present disclosure relates to a wheel hub molding and casting die and a preparation process thereof. The die includes: a casting die shell, a supporting bottom plate, a limiting bottom plate, a lifting module, a module supporting plate, a lower die, an upper die and removable plates. The supporting bottom plate is mounted on the lower surface of the casting die shell. The limiting bottom plate is arranged below the supporting bottom plate. The module supporting plate is movably arranged in a molding cavity. The lifting module is connected between the bottom of the molding cavity and the module supporting plate. The lower die and the upper die are closed to form a pouring cavity. Annular slots are formed in the outer side wall of the upper die. Removable plate slots are formed in the upper surface of the casting die shell.

Abstract: The present invention relates to genetic markers whose expression is correlated with breast cancer. Specifically, the invention provides sets of markers whose expression patterns can be used to differentiate clinical conditions associated with breast cancer, such as the presence or absence of the estrogen receptor ESR1, and BRCA1 and sporadic tumors, and to provide information on the likelihood of tumor distant metastases within five years of initial diagnosis. The invention relates to methods of using these markers to distinguish these conditions. The invention also relates to kits containing ready-to-use microarrays and computer software for data analysis using the statistical methods disclosed herein.

Abstract: The present invention relates to genetic markers whose expression is correlated with breast cancer. Specifically, the invention provides sets of markers whose expression patterns can be used to differentiate clinical conditions associated with breast cancer, such as the presence or absence of the estrogen receptor ESR1, and BRCA1 and sporadic tumors, and to provide information on the likelihood of tumor distant metastases within five years of initial diagnosis. The invention relates to methods of using these markers to distinguish these conditions. The invention also relates to kits containing ready-to-use microarrays and computer software for data analysis using the statistical methods disclosed herein.

Abstract: The present invention relates to genetic markers whose expression is correlated with colon cancer. In one aspect, the invention provides sets of markers whose expression can be used for classifying colon cancer patients into different prognostic categories. In another aspect, the invention provides kits containing marker sets for determining prognosis of colon cancer. In another aspect, the invention provides methods of classifying cancer patients with regard to prognosis.

Abstract: The present invention relates to genetic markers whose expression is correlated with breast cancer. Specifically, the invention provides sets of markers whose expression patterns can be used to differentiate clinical conditions associated with breast cancer, such as the presence or absence of the estrogen receptor ESR1, and BRCA1 and sporadic tumors, and to provide information on the likelihood of tumor distant metastases within five years of initial diagnosis. The invention relates to methods of using these markers to distinguish these conditions. The invention also relates to kits containing ready-to-use microarrays and computer software for data analysis using the statistical methods disclosed herein.

Abstract: The present invention provides prognostic methods for conditions such as cancer, for example, breast cancer, comprising classifying an individual by a plurality of phenotypic, genotypic or clinical characteristics of the condition into a plurality of patient subsets, and analyzing the pattern of expression of prognosis-informative genes identified for that subset in a sample from the individual. The present invention also provides methods for constructing such patient subsets and of identifying prognosis-informative genesets for such subsets. The invention further provides methods of assigning a therapeutic regimen to an individual, microarrays useful for performing prognosis, kits comprising these microarrays, and computer systems and programs for implementing the methods of the invention.

Abstract: The present invention relates to genetic markers whose expression is correlated with breast cancer. Specifically, the invention provides sets of markers whose expression patterns can be used to differentiate clinical conditions associated with breast cancer, such as the presence or absence of the estrogen receptor ESR1, and BRCA1 and sporadic tumors, and to provide information on the likelihood of tumor distant metastases within five years of initial diagnosis. The invention relates to methods of using these markers to distinguish these conditions. The invention also relates to kits containing ready-to-use microarrays and computer software for data analysis using the statistical methods disclosed herein.

Abstract: The present invention provides methods for enhanced detection of biological response patterns. In one embodiment of the invention, genes are grouped into basis genesets according to the co-regulation of their expression. Expression of individual genes within a geneset is indicated with a single gene expression value for the geneset by a projection process. The expression values of genesets, rather than the expression of individual genes, are then used as the basis for comparison and detection of biological response with greatly enhanced sensitivity. In another embodiment of the invention, biological responses are grouped according to the similarity of their biological profile. The methods of the invention have many useful applications, particularly in the fields of drug development and discovery. For example, the methods of the invention may be used to compare biological responses with greatly enhanced sensitivity.

Abstract: The present invention relates to sets of genetic markers whose expression is correlated with prognosis of breast cancer in individuals having breast cancer. Specifically, the invention provides sets of markers whose expression patterns can be used to differentiate individuals having a good prognosis, e.g., no reoccurrence or metastasis within five years of initial diagnosis, and individuals having a poor prognosis, e.g., reoccurrence or metastasis within five years of initial diagnosis. The invention relates to methods of prognosis using these markers. The invention also relates to microarrays containing probes to these markers, and to kits containing ready-to-use microarrays and computer software for data analysis using the prognostic and statistical methods disclosed herein.

Abstract: The present invention provides methods for enhanced detection of biological response patterns. In one embodiment of the invention, genes are grouped into basis genesets according to the co-regulation of their expression. Expression of individual genes within a geneset is indicated with a single gene expression value for the geneset by a projection process. The expression values of genesets, rather than the expression of individual genes, are then used as the basis for comparison and detection of biological response with greatly enhanced sensitivity. In another embodiment of the invention, biological responses are grouped according to the similarity of their biological profile. The methods of the invention have many useful applications, particularly in the fields of drug development and discovery. For example, the methods of the invention may be used to compare biological responses with greatly enhanced sensitivity.

Abstract: The present invention relates to genetic markers whose expression is correlated with breast cancer. Specifically, the invention provides sets of markers whose expression patterns can be used to differentiate clinical conditions associated with breast cancer, such as the presence or absence of the estrogen receptor ESR1, and BRCA1 and sporadic tumors, and to provide information on the likelihood of tumor distant metastases within five years of initial diagnosis. The invention relates to methods of using these markers to distinguish these conditions. The invention also relates to kits containing ready-to-use microarrays and computer software for data analysis using the statistical methods disclosed herein.

Abstract: The present invention relates to genetic markers whose expression is correlated with breast cancer. Specifically, the invention provides sets of markers whose expression patterns can be used to differentiate clinical conditions associated with breast cancer, such as the presence or absence of the estrogen receptor ESR1, and BRCA1 and sporadic tumors, and to provide information on the likelihood of tumor distant metastases within five years of initial diagnosis. The invention relates to methods of using these markers to distinguish these conditions. The invention also relates to kits containing ready-to-use microarrays and computer software for data analysis using the statistical methods disclosed herein.

Abstract: The present invention provides prognostic methods for conditions such as cancer, for example, breast cancer, comprising classifying an individual by a plurality of phenotypic, genotypic or clinical characteristics of the condition into a plurality of patient subsets, and analyzing the pattern of expression of prognosis-informative genes identified for that subset in a sample from the individual. The present invention also provides methods for constructing such patient subsets and of identifying prognosis-informative genesets for such subsets. The invention further provides methods of assigning a therapeutic regimen to an individual, microarrays useful for performing prognosis, kits comprising these microarrays, and computer systems and programs for implementing the methods of the invention.