Abstract: The use of a genetic method to down-regulate RBO/EFR3/EFR3A/EFR3B proteins, TTC7 protein or PI4KIII? enzyme protein which interacts with RBO/EFR3/EFR3A/EFR3B proteins and TTC7 protein, or the use of a drug to inhibit PI4KIII? protein kinase activity reduces the accumulation of A?42 within neurons and age-dependent synaptic transmission failure and other obstacles in a fruit fly AD model, and obtains an effect of improving the learning and memory abilities of AD model mice. Provided is a method for using an RBO/EFR3/EFR3A/EFR3B inhibitor, a TTC7 inhibitor and a PI4KIII? inhibitor to treat Alzheimer's disease. Also provided is a method for screening a drug treating Alzheimer's disease by whether A? secretion by nerve cells is promoted or not.

Abstract: Presented herein are methodologies for generating clock signals for transceivers that rely on frequency and phase error correction functions. The methodology includes generating a differential clock signal at a fundamental frequency, generating, based on the differential clock signal and using a multiphase generator, four quadrature signals at the fundamental frequency, supplying the four quadrature signals to an injection-locked phase rotator, and outputting, from the injection-locked phase rotator, a phase adjusted multiphase clock signal based on the four quadrature signals.

Abstract: Disclosed is a method for determining a whole macro-micro process of rock deformation and failure based on a four-parameter test, including following steps: firstly, obtaining acoustic emission data and deformation data of a sample in a compression test, and then calculating the deformation data according to a finite deformation theory to obtain a mean rotation angle ? at each stress level; using Grassberger-Procaccia (G-P) algorithm to calculate the acoustic emission data, and obtaining a fractal dimension of a temporal distribution DT of an acoustic emission signal and calculating a fractal dimension of a spatial distribution DS; obtaining a microscopic morphology of a fracture surface by scanning electron microscope (SEM) test after the compression test, and calculating a fractal dimension DA of the fracture surface; finally, obtaining a mathematical trend relationship between ? and DT, DS and DA according to a comprehensive analysis of DT, DS, DA and ?.

Abstract: Circuits and methods for multi-phase clock generators and phase interpolators are provided. The multi-phase clock generators include a delay line and multi-phase injection locked oscillator. At each stage of the multi-phase injection locked oscillator, injection currents are provided from a corresponding stage of the delay line. Outputs of the multi-phase injection locked oscillator and provided to mixers which produce inputs to an operational transconductance amplifier which provides feedback to the delay line and the multi-phase injection locked oscillator. The phase interpolator uses a technique of flipping certain input clock signals to reduce the number of components required while still being able to interpolate phase over 360 degrees and to reduce noise.

Abstract: Presented herein are methodologies for generating clock signals for transceivers that rely on frequency and phase error correction functions. The methodology includes generating a differential clock signal at a fundamental frequency, generating, based on the differential clock signal and using a multiphase generator, four quadrature signals at the fundamental frequency, supplying the four quadrature signals to an injection-locked phase rotator, and outputting, from the injection-locked phase rotator, a phase adjusted multiphase clock signal based on the four quadrature signals.

Abstract: Presented herein are methodologies for generating clock signals for transceivers that rely on frequency and phase error correction functions. The methodology includes generating a differential clock signal at a fundamental frequency, generating, based on the differential clock signal and using a multiphase generator, four quadrature signals at the fundamental frequency, supplying the four quadrature signals to an injection-locked phase rotator, and outputting, from the injection-locked phase rotator, a phase adjusted multiphase clock signal based on the four quadrature signals.

Abstract: A method and a system of distinguishing between a human and a machine are disclosed. The method includes: when a request for accessing a designated network service is received, recording information of the request which include a time of receiving the request and information of an access object that sends the request; computing a statistical value of requests sent by the access object in real time based on a record; and determining the access object to be abnormal when the statistical value of the requests sent by the access object falls outside a predetermined normal range. The disclosed system of distinguishing between a human and a machine includes a recording module, a computation module and a determination module. Identification between humans and machines using the disclosed scheme is difficult to be cracked down and can improve an accuracy rate of human-machine identification.

Abstract: A method and an apparatus for distinguishing humans from computers and for controlling access to network services. One intended application of the method is a CAPTCHA technique, deployed using a shared Trusted Computing technology over a trusted network of a user terminal, a network server, and a Trusted Party, any of which may be at a Decision Point. The method distinguishes a human user making a legitimate request for network access from a programmed computer making undesired requests, by detecting unusually high network access request frequencies made by an identifiable user and/or a trusted module from the user terminal. The CAPTCHA function is further used to improve the method for controlling access to network services. The information transmitted between the members of the trusted network may be encrypted.

Abstract: The present disclosure provides an adaptive optical retina imaging apparatus and method. The adaptive optical retina imaging apparatus comprises an optical processing unit, an adaptive optical unit, a two-dimensional scanning unit and a primary aberration correcting unit, in which an imaging unit included in the optical processing unit is imaging based on the signal after high order aberration compensation and low order aberration compensation.

Abstract: A method and an apparatus for distinguishing humans from computers and for controlling access to network services. One intended application of the method is a CAPTCHA technique, deployed using a shared Trusted Computing technology over a trusted network of a user terminal, a network server, and a Trusted Party, any of which may be at a Decision Point. The method distinguishes a human user making a legitimate request for network access from a programmed computer making undesired requests, by detecting unusually high network access request frequencies made by an identifiable user and/or a trusted module from the user terminal. The CAPTCHA function is further used to improve the method for controlling access to network services. The information transmitted between the members of the trusted network may be encrypted.

Abstract: A terminal identification method, a machine identification code registration method and related system and apparatus are disclosed. After receiving a first request for which signature or certificate verification is to be performed from a terminal, a service network obtains a signature or certificate of a trusted party for a machine identification code identifier of the terminal from the first request, wherein the machine identification code identifier being an identifier allocated by the trusted party to the machine identification code of the terminal. The service network verifies the obtained signature or certificate, and if a verification result indicates legitimacy, identifies the terminal using the machine identification code identifier obtained from the signature or certificate. The present disclosure further provides a trusted party and a method of registering a machine identification code by the trusted party.

Abstract: Provided are a microscopic surgery system and a navigation method guided by optical coherence tomography. The microscopic surgery system may include: an object lens; a surgical microscope unit configured to perform two-dimensional imaging on an area to operate on via the object lens; an optical coherence tomography unit configured to perform two-dimensional tomography imaging on the area via the object lens, with an imaging field calibrated according to that of the surgical microscope unit; a processor configured to obtain navigation information based on the two-dimensional imaging by the surgical microscope unit and the two-dimensional tomography imaging by the optical coherence tomography unit, the navigation information comprising positional information of a body part to operate on and a surgical instrument for operating on the body part; and an output unit configured to output the navigation information to guide the surgical instrument to the body part.

Abstract: A method and an apparatus for distinguishing humans from computers and for controlling access to network services. One intended application of the method is a CAPTCHA technique, deployed using a shared Trusted Computing technology over a trusted network of a user terminal, a network server, and a Trusted Party, any of which may be at a Decision Point. The method distinguishes a human user making a legitimate request for network access from a programmed computer making undesired requests, by detecting unusually high network access request frequencies made by an identifiable user and/or a trusted module from the user terminal. The CAPTCHA function is further used to improve the method for controlling access to network services. The information transmitted between the members of the trusted network may be encrypted.

Abstract: A terminal identification method, a machine identification code registration method and related system and apparatus are disclosed. After receiving a first request for which signature or certificate verification is to be performed from a terminal, a service network obtains a signature or certificate of a trusted party for a machine identification code identifier of the terminal from the first request, wherein the machine identification code identifier being an identifier allocated by the trusted party to the machine identification code of the terminal. The service network verifies the obtained signature or certificate, and if a verification result indicates legitimacy, identifies the terminal using the machine identification code identifier obtained from the signature or certificate. The present disclosure further provides a trusted party and a method of registering a machine identification code by the trusted party.

Abstract: An adaptive optical objective inspection instrument for optic nerve function comprises: a sub-system for measuring wave aberration of human's eyes, including a near infrared beacon light source, an intermediate optical system, a wavefront corrector and a wavefront sensor, configured to measure and obtain wave aberration of testee's eyes, the intermediate optical system arranged along an optical path between the near infrared beacon light source and the wavefront sensor, and the wavefront corrector arranged in the optical path of the intermediate optical system; a sub-system for correcting wave aberration of human's eyes, including the intermediate optical system, the wavefront corrector and a control unit, the control unit configured to drive and control the wavefront corrector to correct the wave aberration of testee's eyes according to the measured wave aberration; and a sub-system for inspecting optic nerve function, including a visual stimulus display and a system for collecting visual evoked potential si

Abstract: An adaptive optical objective inspection instrument for optic nerve function comprises: a sub-system for measuring wave aberration of human's eyes, including a near infrared beacon light source, an intermediate optical system, a wavefront corrector and a wavefront sensor, configured to measure and obtain wave aberration of testee's eyes, the intermediate optical system arranged along an optical path between the near infrared beacon light source and the wavefront sensor, and the wavefront corrector arranged in the optical path of the intermediate optical system; a sub-system for correcting wave aberration of human's eyes, including the intermediate optical system, the wavefront corrector and a control unit, the control unit configured to drive and control the wavefront corrector to correct the wave aberration of testee's eyes according to the measured wave aberration; and a sub-system for inspecting optic nerve function, including a visual stimulus display and a system for collecting visual evoked potential si

Abstract: A method and a system of distinguishing between a human and a machine are disclosed. The method includes: when a request for accessing a designated network service is received, recording information of the request which include a time of receiving the request and information of an access object that sends the request; computing a statistical value of requests sent by the access object in real time based on a record; and determining the access object to be abnormal when the statistical value of the requests sent by the access object falls outside a predetermined normal range. The disclosed system of distinguishing between a human and a machine includes a recording module, a computation module and a determination module. Identification between humans and machines using the disclosed scheme is difficult to be cracked down and can improve an accuracy rate of human-machine identification.

Abstract: A method and an apparatus for distinguishing humans from computers. During user registration, a computer prompts a human user to provide a spoken response to certain authentication information for registration. The computer obtains registration voice data from the spoken response and establishes a registration voiceprint of the human user. During user logon, the computer identifies the user requesting to logon by the user's logon credentials, provides authentication information for logon to the user, and prompts the user to provide a spoken response to the authentication information for logon. The computer obtains logon voice data from the spoken response, and establishes a logon voiceprint of the user. The computer then determines whether the user requesting to logon is human by comparing the logon voiceprint with the registration voiceprint.

Abstract: A method and a system of distinguishing between a human and a machine are disclosed. The method includes: when a request for accessing a designated network service is received, recording information of the request which include a time of receiving the request and information of an access object that sends the request; computing a statistical value of requests sent by the access object in real time based on a record; and determining the access object to be abnormal when the statistical value of the requests sent by the access object falls outside a predetermined normal range. The disclosed system of distinguishing between a human and a machine includes a recording module, a computation module and a determination module. Identification between humans and machines using the disclosed scheme is difficult to be cracked down and can improve an accuracy rate of human-machine identification.

Abstract: The present disclosure provides an adaptive optical retina imaging apparatus and method. The adaptive optical retina imaging apparatus comprises an optical processing unit, an adaptive optical unit, a two-dimensional scanning unit and a primary aberration correcting unit, in which an imaging unit included in the optical processing unit is imaging based on the signal after high order aberration compensation and low order aberration compensation.