Abstract: Provided herein is a model, in particular a mouse model, for assessing or evaluating toxicity to an immunotherapy, for example a therapeutic cell therapy, such as a cell therapy containing engineered cells, such as T cells, expressing a recombinant receptor, e.g. a chimeric antigen receptor (CAR). Also provided is a method for generating the mouse model. Also provided herein are methods of use for the mouse models of toxicity, such as to evaluate modified or alternative immunotherapies, and/or to evaluate test agents, including agents to assess as potential interventions to reduce, prevent, or ameliorate toxicity to immunotherapy in human subjects and/or for use in combination with an immunotherapy, e.g. CAR?T cell therapy.

Abstract: An analyte meter having a test strip ejector. The analyte meter includes a housing body including a front side, a back side, a first side, a second side, an end, and a test strip port at the end configured to receive a test strip; and a strip ejector configured to eject the test strip from the test strip port. The test strip ejector includes a slide member slidable relative to the housing body, an engagement member coupled to the slide member and configured to be contacted by a user, the engagement member located on the back side of the housing body opposite then display screen, and a push member coupled to the slide member and positioned to be engageable with the end of the test strip. Test strip ejectors and methods of ejecting test strips are provided, as are numerous other aspects.

Abstract: The present disclosure provides a compound eye-based in-situ monitoring unit, a micro-adjustment unit, and a multi-spectral imaging system thereof. The compound eye-based in-situ monitoring unit includes a spherical installation cover and an imaging assembly disposed on the spherical installation cover, where the spherical installation cover is provided with a spherical grid array, the spherical grid array includes 20 installation points (five rows and four columns), one imaging assembly is installed on each installation point, the imaging assemblies include a charge coupled device (CCD) optical digital camera assembly, a digital image correlation (DIC) light source assembly, an infrared (IR) spectrum assembly, a Raman spectrum assembly, and a terahertz light source assembly.

Abstract: Embodiments manage use of different network connections for data transfer in view of priority information and a data usage plan identifying threshold limits associated with the different network connections. A computing device receives data transfer requests from applications executing on the computing device. The data transfer requests have priority information associated therewith. The computing device compares the priority information with available network connections. One or more of the data transfer requests are selected for initiation based on the comparison and on the threshold limits.

Abstract: Provided are receptor tyrosine kinase-like orphan receptor 1 (ROR1)-binding molecules, in particular, to human antibodies specific for ROR1, including antibody fragments. The present disclosure further relates to recombinant receptors, including chimeric antigen receptors (CARs) that contain such antibodies or fragments, and polynucleotides that encode the antibodies, antigen-binding fragments or receptors specific for ROR1. The disclosure further relates to genetically engineered cells, containing such ROR1-binding proteins and receptors, and related methods and uses thereof in adoptive cell therapy.

Abstract: A locking system for securing, within a rectangular frame aperture of a safe, a hinged door having a perimeter and an external side and an internal side and occupying a first vertical plane, the door being configured for suspension on hinges. The locking system comprises a key axle, a disc, a plate. When the key axle is rotated the disc is caused to rotate and the plate slides horizontally to extend a distal end of the plate towards beyond the door perimeter.

Abstract: The present disclosure relates in some aspects to methods, compositions and uses involving immunotherapies, such as adoptive cell therapy, e.g., T cell therapy, and an immunomodulatory compound, such as a structural or functional analog or derivative of thalidomide and/or an inhibitor of E3-ubiquitin ligase. The provided methods, compositions and uses include those for combination therapies involving the administration or use of one or more immunomodulatory compounds in conjunction with a T cell therapy, such as a genetically engineered T cell therapy involving cells engineered with a recombinant receptor, such as chimeric antigen receptor (CAR)-expressing T cells. Also provided are compositions, methods of administration to subjects, articles of manufacture and kits for use in the methods.

Abstract: Embodiments manage use of different network connections for data transfer in view of priority information and a data usage plan identifying threshold limits associated with the different network connections. A computing device receives data transfer requests from applications executing on the computing device. The data transfer requests have priority information associated therewith. The computing device compares the priority information with available network connections. One or more of the data transfer requests are selected for initiation based on the comparison and on the threshold limits.

Abstract: The invention is mainly related to a synthesis method of supported two-dimensional transition metal carbides for Fenton-like catalysis, which includes the following steps: (1) preparing two-dimensional transition metal carbides powders; (2) dispersing the two-dimensional transition metal carbides powders into intercalants solution to perform an intercalation reaction, and then centrifuging, washing, and freeze-drying to obtain intercalated products; (3) dispersing a certain quality previously obtained intercalated powders into ultrapure water and heating for pre-reaction, and then adding hydrogen peroxide solution to the pre-reacted mixed solution under ice-water bath for secondary etching, resting, centrifuging and gently decanting a supernatant to obtain the final Fenton-like catalysts.

Abstract: Provided are binding molecules, such as TCRs or antigen binding fragments thereof and antibodies and antigen-binding fragments thereof, such as those that recognize or bind human papilloma virus (HPV) 16, including HPV 16 E6 and HPV 16 E7. Also provided are engineered cells containing such binding molecules, compositions containing the binding molecules or engineered cells, and methods of treatment, such as administration of the binding molecules, engineered cells, or compositions.

Abstract: A method for evaluating IO performance of cache servers includes: collecting basic data of all to-be-evaluated cache servers, where the basic data includes at least service data, disk configuration, load data, and performance data; filtering the basic data of all the to-be-evaluated cache servers, and classifying cache servers whose basic data have the same data characteristics into one category; statistically analyzing basic data of cache servers of each category, to obtain evaluation indexes for the cache servers of each category; and determining, according to the evaluation indexes for the cache servers of each category, disk IO configuration requirements for the cache servers of each category, where the disk IO configuration requirements include at least a disk capacity configuration requirement and a disk load algorithm configuration requirement.

Abstract: The embodiments of the present disclosure may disclose methods and systems for information recommendation. The method for information recommendation method may include: determining a violation count corresponding to a violation behavior in historical driving behavior of a driver; determining, based on the violation behavior and its corresponding violation count, information to be recommended; and sending the information to be recommended to a driver terminal of the driver.

Abstract: Provided herein are uses of anti-B cell maturation antigen (BCMA) chimeric antigen receptors (CARs) for treating B-cell related conditions, such as BCMA-expressing cancers.

Abstract: The present disclosure relates to systems and methods for determining a potential malicious event. The systems and methods may obtain real-time information related to a vehicle. The systems and methods may determine a probability of arising malicious event based on the real-time information of the vehicle. The systems and methods may determine whether the probability of arising malicious event exceeds a probability threshold. The systems and methods may in response to a determination that the probability of arising malicious event exceeds the probability threshold, determine that a potential malicious event exists.

Abstract: Embodiments are disclosed of a hybrid automatic repeat request feedback method and apparatus, and relates to the field of communications technologies. The hybrid automatic repeat request feedback method is applied to a receive end. After receiving data information sent by a transmit end, the receive end may determine, when target data in the data information is not checked, a measurement value of the target data, then generate feedback information based on the measurement value, and subsequently, send the feedback information to the transmit end, so that the transmit end can determine, based on the feedback information, whether the target data needs to be retransmitted.

Abstract: Provided herein are methods for target gene sequencing and single cell barcoding in conjunction with analysis of gene expression in single cells. In some embodiments, the target gene is an immune molecule, such as an antibody or TCR. In some embodiments, the methods can be used to carry out transcriptome sequencing, e.g., RNA sequencing, to capture transcriptome of single cells paired with full receptor immune receptor sequences such that information about the immune repertoire and transcriptome of a cell can be determined. Also provided are polynucleotide libraries for use in carrying out transcriptome analysis and immune molecule, e.g., antibody or TCR, sequencing.

Abstract: An all-optical neural network that utilizes light beams and optical components to implement layers of the neural network is disclosed herein. The all-optical neural network includes an input layer, zero or more hidden layers, and an output layer. Each layer of the neural network is configured to simulate linear and nonlinear operations of a conventional artificial neural network neuron on an optical signal. In an embodiment, the optical linear operation is performed by a spatial light modulator and an optical lens. The optical lens performs a Fourier transformation on the set of light beams and sums light beams with similar propagation orientations. The optical nonlinear operation is implemented utilizing a nonlinear optical medium having an electromagnetically induced transparency characteristic whose transmission of a probe beam of light is controlled by the intermediate output of a coupling beam of light from the optical linear operation.

Abstract: A method for evaluating IO performance of cache servers includes: collecting basic data of all to-be-evaluated cache servers, where the basic data includes at least service data, disk configuration, load data, and performance data; filtering the basic data of all the to-be-evaluated cache servers, and classifying cache servers whose basic data have the same data characteristics into one category; statistically analyzing basic data of cache servers of each category, to obtain evaluation indexes for the cache servers of each category; and determining, according to the evaluation indexes for the cache servers of each category, disk IO configuration requirements for the cache servers of each category, where the disk IO configuration requirements include at least a disk capacity configuration requirement and a disk load algorithm configuration requirement.

Abstract: A ring shear and seepage-coupled apparatus and a ring shear and seepage-coupled test system for rock and rock fracture under tension or compression stress are provided, relating to the technical field of mechanical testing devices. As to the ring shear and seepage-coupled apparatus, an axial piston rod is connected with an upper shear box, a torque transferring shaft is connected with a lower shear box, an axial force transducer is provided on the axial piston rod, a torque transducer is provided on the torque transmitting shaft, and a force transferring plate is fixedly connected onto the upper shear box. The force transferring plate is able to transmit a counter force for exerting a torque. Radial and circumferential seepage tests can be achieved by providing a seepage structure. The ring shear and seepage-coupled test system comprises a servo pump and the ring shear and seepage-coupled apparatus as mentioned above.