Abstract: A GIP and GLP-1 dual receptor agonist, a pharmaceutical composition, and the use. In particular, the present application relates to a compound represented by formula I, a pharmaceutical composition comprising the compound, and the use of the compound as a GIP and GLP-1 dual receptor agonist in the field of medicine. The compound represented by formula I exhibits excellent GIPR and GLP-1R agonist activity and excellent pharmaceutical activity in reducing blood sugar and controlling body weight, is a therapeutic drug having a clinical application prospect, and can be used for preventing and treating diseases such as diabetes, diabetes complications, obesity, or obesity complications.

Abstract: The present invention provides an epitope peptide of a RAS G13D mutant, an antigen presenting cell expressing the epitope peptide, a tumor vaccine containing the antigen presenting cell, and a use of the tumor vaccine in the prevention or treatment of a tumor having RAS G13D mutation. The present invention also provides a T cell receptor (TCR) specifically recognizing a RAS G13D mutant, a conjugate and a fusion protein containing the TCR, an immune cell expressing the TCR, a T cell drug containing the immune cell, and a use of the T cell drug in the prevention or treatment of a tumor having RAS G13D mutation.

Abstract: The capability to print to a portable document format (PDF) file is provided in a virtualized computing environment that supports a virtual desktop infrastructure (VDI). Printing-related properties, of local printers coupled to a client device, are provided to a host, so that virtual printers at the host can be configured with the printing-related properties. A simulator may be provided at the host to receive the printing-related properties from the client device and to receive a query from a virtualized computing instance for the printing-related properties, instead of the query being directly sent to the client device.

Abstract: Provided is a lift table apparatus for log splitting. The lift table apparatus includes a lift frame, a lock pin, a control lever, and a cable. The lift frame is configured to be attached to a beam and a hydraulic cylinder of a log splitter. The lift frame is movable from a vertical position to a horizontal position by the hydraulic cylinder when the hydraulic cylinder is retracted. The lock pin is configured to be attached to the beam and locks the lift frame in the horizontal position. The control lever is configured to be attached to a hydraulic flow control valve of the log splitter. The cable is connected to the lock pin and the control lever. When the control lever is pulled out, the cable pulls the lock pin out to enable the lift frame to be released from the horizontal position and moved to the vertical position.

Abstract: A planar transformer includes a magnetic core assembly, at least one printed circuit board and at least one winding module. The magnetic core assembly includes a first magnetic core and a second magnetic core. The at least one printed circuit board is disposed between the first magnetic core and the second magnetic core. The printed circuit board includes a first winding. The at least one winding module is disposed between the first magnetic core and the second magnetic core. The winding module includes a second winding and a plastic molding layer. At least a portion of the second winding is covered by the plastic molding layer. The at least one printed circuit board and the at least one winding module are individual components.

Abstract: The present disclosure relates to the technical field of fiber-optic gas sensing and laser photoacoustic spectroscopy, and reliability of a gas detection system is improved by actively selecting a working frequency of low noise interference combined with an optical fiber photoacoustic sensing probe capable of isolating high-frequency noise. A gas enters a photoacoustic microcavity through gaps on a sound-sensitive diaphragm after diffusing into a miniature air chamber through a plurality of micropores. Photoacoustic excitation light is incident into the photoacoustic microcavity through a fiber-optic collimator and then excited to generate a photoacoustic pressure wave to cause the sound-sensitive diaphragm to vibrate periodically. An end face of a single-mode optical fiber and the sound-sensitive diaphragm constitutes a fiber-optic Fabry-Perot interferometer. The interferometer measures a deflection of the diaphragm and inverts a concentration of the to-be-measured gas.

Abstract: Methods for creating a knowledge graph for a video are disclosed. Aspects include obtaining the video, processing the video to extract audio information and video information, and storing the extracted audio information and video information with a timestamp corresponding its occurrence in the video. Aspects also include creating a plurality of groups of the extracted audio information and video information based at least in part on the timestamps and extracting two or more keywords from each of the plurality of groups. Aspects further include identifying a relationship between the two or more keywords based on the extracted audio information and video information and creating a graph having a plurality of nodes and a plurality of links that connect a pair of nodes of the plurality of nodes. Each node corresponds to an extracted keyword and each link corresponds to the identified relationship between the pair of nodes.

Abstract: The present disclosure provides a base plate integrating passive devices and a method for manufacturing the same, which relate to the technical field of radio frequency devices. The base plate integrating passive devices of the present disclosure includes a substrate base plate and the passive devices disposed on the substrate base plate, the passive devices including at least an inductor, the inductor including a plurality of open ring portions arranged and connected in sequence in a direction away from the base plate, wherein an interlayer dielectric layer is disposed between the open ring portions disposed adjacently, and the open ring portions disposed adjacently are electrically connected through a first via hole penetrating the interlayer dielectric layer; orthographic projections of any two of the open ring portions on the substrate base plate at least partially overlap.

Abstract: Embodiments of a three-dimensional (3D) memory device and a method of operating the 3D memory device are provided. The 3D memory device includes an array of 3D NAND memory cells, an array of static random-access memory (SRAM) cells, and a peripheral circuit. The array of SRAM cells and the peripheral circuit arranged at one side are bonded with the array of 3D NAND memory cells at another side to form a chip. Data is received from a host through the peripheral circuit, buffered in the array of SRAM cells, and transmitted from the array of SRAM cells to the array of 3D NAND memory cells. The data is programmed into the array of 3D NAND memory cells.

Abstract: A method for analyzing cell epigenomics from multiple dimensions. The method comprises the following steps: by using ChiTag transposase and conventional Tn5 transposase in cells, respectively embedding different linker sequences, and achieving common analysis of information of a chromatin open region and information of a specific protein binding sequence on a cellular level. The method has important application prospects in aspects such as study of development and/or disease related cell population heterogeneity, drawing of a cell map, analysis of tumor cells having different clinical characteristics, and clinical study of evolution and/or metastasis of tumor cells.

Abstract: Systems and methods for evaluating and presenting robustness of a radiotherapy treatment plan for use in radiotherapy are discussed. An exemplary system includes a processor to generate, in a radiation simulation in accordance with the treatment plan under evaluation, dose distributions at an anatomical structure under a nominal condition and one or more artificially imposed uncertainty conditions, determine a dose distribution characteristic for the anatomical structure using the received dose distributions, and generate a robustness indicator of the treatment plan. The dose distributions may be determined at a target structure and one or more structures at risk, and presented graphically in a three-dimensional dose-volume-structure space. An output circuit can output the dose distribution characteristic or the robustness indicator to a user or a treatment planning system.

Abstract: Methods of entrapping enzymes in chitosan matrices using mild conditions, such as methods that are compatible with the entrapment of acid-sensitive and/or heat sensitive enzymes, are described. The methods can provide biocatalytic materials with high chitosan to enzyme mass ratios where one or more enzymes can remain active and stably entrapped in the chitosan matrix for many months and/or after repeated washings. Also described are materials including a solid chitosan matrix having at least one enzyme stably entrapped therein, including fabrics, textiles and other flexible materials at least partially coated with one or more layer of the solid chitosan matrix having at least one enzyme stably entrapped therein and the use of the materials as biocatalyst systems, for example in biogas upgrading and other applications.

Abstract: Provided are a sequencing library and applications thereof. The provided sequencing library includes a first nucleic acid molecule and a second nucleic acid molecule. The first nucleic acid molecule carries a cell index sequence and a droplet index sequence. The second nucleic acid molecule carries an insert fragment and a cell index sequence.

Abstract: Provided in the present invention is a method for constructing single cell sequencing libraries, comprising the following steps: a) lysing a single cell to obtain a single cell lysate; b) separating the nucleus and the cytoplasm in the single cell lysate obtained in step a) to obtain a nuclear solution and a total RNA solution; and c) constructing a chromatin DNA library with the nuclear solution obtained in step b) to obtain a chromatin-accessibility sequencing library of the single cell; and constructing a transcriptome library with the total RNA solution obtained in step b) to obtain a transcriptome sequencing library of the single cell.

Abstract: A test device and method for top-of-the-line corrosion (TLC) of a high-temperature high-pressure wet gas pipeline. The device mainly includes: a metal top cap, a metal reaction cylinder, a first thermometer, a second thermometer, a plastic transparent measuring cylinder, a condensed water collection tube, an atomic spectrometer, a third thermometer, a rubber seal cover, a condensate droplet, a threaded hole, a condensation chamber, a pipeline sample, a temperature measuring hole, and a 30-degree tilt angle. The device and method can effectively simulate TLC of a wet gas pipeline under a high-temperature high-pressure environment. The device and method can test the high-temperature high-pressure TLC of the wet gas pipeline under different temperature differences (between a surface temperature of the pipeline and a gas temperature) and various corrosion media.

Abstract: A method for constructing a library of cell-free DNAs in body fluids, comprising directly acting a transposase or an endonuclease on a body fluid sample, fragmenting the cell-free DNAs within, and performing amplification to obtain a library. Also provided is a test kit using the present method for prenatal diagnosis or early detection of cancer.

Abstract: A test device and method for top-of-the-line corrosion (TLC) of a high-temperature high-pressure wet gas pipeline. The device mainly includes: a metal top cap, a metal reaction cylinder, a first thermometer, a second thermometer, a plastic transparent measuring cylinder, a condensed water collection tube, an atomic spectrometer, a third thermometer, a rubber seal cover, a condensate droplet, a threaded hole, a condensation chamber, a pipeline sample, a temperature measuring hole, and a 30-degree tilt angle. The device and method can effectively simulate TLC of a wet gas pipeline under a high-temperature high-pressure environment. The device and method can test the high-temperature high-pressure TLC of the wet gas pipeline under different temperature differences (between a surface temperature of the pipeline and a gas temperature) and various corrosion media.

Abstract: Methods of entrapping enzymes in chitosan matrices using mild conditions, such as methods that are compatible with the entrapment of acid-sensitive and/or heat sensitive enzymes, are described. The methods can provide biocatalytic materials with high chitosan to enzyme mass ratios where one or more enzymes can remain active and stably entrapped in the chitosan matrix for many months and/or after repeated washings. Also described are materials including a solid chitosan matrix having at least one enzyme stably entrapped therein, including fabrics, textiles and other flexible materials at least partially coated with one or more layer of the solid chitosan matrix having at least one enzyme stably entrapped therein and the use of the materials as biocatalyst systems, for example in biogas upgrading and other applications.