Abstract: The present invention discloses a heat exchanger and a heat exchange method, which can recover heat from a high-temperature fluid during transport. The heat exchanger includes a closed heat exchange region and a heat-receiving fluid coil mounted therein. The heat exchange method is to pass the high-temperature fluid through a heat exchange base plate in contact therewith so as to transfer heat to the heat-receiving fluid. According to the design of the heat exchanger in the present invention, modification of the original transport pipeline and mounting of a new apparatus are very convenient, the heat exchange area can be increased while saving the cost, and the heat exchange efficiency is improved.

Abstract: The disclosure relates to inhibitors of PCSK9 useful in the treatment of cholesterol lipid metabolism, and other diseases in which PCSK9 plays a role, having the Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, N-oxide, or tautomer thereof, wherein R1, R1, R1, R1, R1, R1, R1, R1, R1, X1, X2, and X3 are described herein.

Abstract: The disclosure relates to inhibitors of PCSK9 useful in the treatment of cholesterol lipid metabolism, and other diseases in which PCSK9 plays a role, having the Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, N-oxide, or tautomer thereof, wherein X1, R1, R2, R3, R4, R5, R6, R6?, R7, R7?, R8, R9, R9?, R10, R11, R12, and n are described herein.

Abstract: The disclosure relates to inhibitors of PCSK9 useful in the treatment of lipid metabolism, and other diseases in which PCSK9 plays a role, having the Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, or tautomer thereof, wherein R1, X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, X11, X12, and X13 are described herein.

Abstract: The disclosure relates to inhibitors of PCSK9 useful in the treatment of cholesterol lipid metabolism, and other diseases in which PCSK9 plays a role, having the Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, N-oxide, or tautomer thereof, wherein R1, R1, R1, R1, R1, R1, R1, R1, R1, X1, X2, and X3 are described herein.

Abstract: The disclosure relates to inhibitors of PCSK9 useful in the treatment of cholesterol lipid metabolism, and other diseases in which PCSK9 plays a role, having the Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, N-oxide, or tautomer thereof, wherein R1, R1, R1, R1, R1, R1, R1, R1, R1, X1, X2, and X3 are described herein.

Abstract: A method for transmitting a request message and an apparatus are disclosed, to resolve a prior-art problem that in an ICT network, when a request message is transmitted, a probability that the request message fails to be transmitted is increased, and reliability of transmitting the request message is reduced. The method includes: determining, by a dispatcher according to information that is about a first controller and that is included in a received request message, a corresponding first driver adaptation plug-in group, where the first controller is connected to at least one driver adaptation plug-in included in the first driver adaptation plug-in group; and selecting, by the dispatcher from the at least one driver adaptation plug-in, at least one to-be-selected driver adaptation plug-in whose running status is normal, and eventually sending the request message to the first controller by using one to-be-selected driver adaptation plug-in.

Abstract: The disclosure relates to inhibitors of PCSK9 useful in the treatment of cholesterol lipid metabolism, and other diseases in which PCSK9 plays a role, having the Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, N-oxide, or tautomer thereof, wherein R1, R1, R1, R1, R1, R1, R1, R1, R1, X1, X2, and X3 are described herein.

Abstract: A method for transmitting a request message and an apparatus are disclosed, to resolve a prior-art problem that in an ICT network, when a request message is transmitted, a probability that the request message fails to be transmitted is increased, and reliability of transmitting the request message is reduced. The method includes: determining, by a dispatcher according to information that is about a first controller and that is included in a received request message, a corresponding first driver adaptation plug-in group, where the first controller is connected to at least one driver adaptation plug-in included in the first driver adaptation plug-in group; and selecting, by the dispatcher from the at least one driver adaptation plug-in, at least one to-be-selected driver adaptation plug-in whose running status is normal, and eventually sending the request message to the first controller by using one to-be-selected driver adaptation plug-in.