Abstract: The present invention discloses CLDN18.2-targeting antibodies, bispecific antibodies and use thereof The CLDN18.2-targeting antibody is a single-domain heavy-chain antibody that has high affinity for tumor cells endogenously expressing CLDN18.2 and can induce high endocytic activity. The bispecific antibody can target CLDN18.2 and CD3 and retains the binding effect of an Fc to an FcRn; meanwhile, a mutant Fc is preferred so as to reduce the binding to an FcgR and thus the activation of non-specific T cells caused by the cross-linking of an FcgR. The CD3-terminus activity is optimized so that the release of common cytokines in CRS, such as IL6 and TNF? can be reduced.

Abstract: A lightning prewarning-based method for active protection against a lightning strike on an important transmission channel includes collecting meteorological element data, and establishing a transmission line-specific lightning strike probability prewarning model; using a maximum probability of a lightning strike prewarning level as a lightning strike prewarning level; performing equivalence calculation on a large-scale regional power system, using a minimum sum of a power loss risk cost and a regulation cost as an optimized objective function, and establishing a power flow transfer optimization model; and comparing a sum of a regulation cost and load power loss risk cost caused after the tie line is disconnected if regulation is performed before a lightning strike, and a load power loss risk cost caused if regulation is not performed, and when the regulation cost is not greater than the load power loss risk cost, performing regulation before the lightning strike.