Patents by Inventor Yuh-Jyh Jong
Yuh-Jyh Jong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230377746Abstract: A method for establishing robust prediction model is adapted for solving the problem that the conventional prediction model cannot generate stable and credible results with missing data. The method of the present invention includes the following steps: obtaining pre-established single-modality standard models respectively based on each type of modalities from samples; extracting modality sets each having the same modality types from the samples to establish corresponding multi-modalities standard models; extracting multiple combinations of the modality sets from the samples having complete modalities to be training data, wherein the multiple combinations of the modality sets can be classified into single-modality, multi-modalities and complete-modalities; inputting said training data into a to-be trained prediction model, and modifying the prediction model by said single-modality standard models and said multi-modalities standard models to obtain a well-trained prediction model.Type: ApplicationFiled: June 30, 2022Publication date: November 23, 2023Inventors: Yuh-Jyh JONG, Yuan-Han YANG, Ming-Chung CHOU, Shin-Mu TSENG, Jui-Hung HUNG, Hui-Min HSIEH, Shyh-Shin CHIOU
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Patent number: 9045793Abstract: The present invention relates to a method of regulating the expression level of survival of motor neuron 1 (SMN1) comprising administering to a subject in need thereof a therapeutically effective amount of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) regulator and a pharmaceutically acceptable carrier. The present invention also relates to a method of detecting enzyme activity of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) in human fibroblasts comprising detecting protein expression level of survival of motor neuron 1 (SMN1).Type: GrantFiled: February 23, 2011Date of Patent: June 2, 2015Assignee: KAOHSIUNG MEDICAL UNIVERSITYInventors: Yuh-Jyh Jong, Shih-Hsien Hsu, Jan-Gowth Chang
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Patent number: 8946503Abstract: A nucleic acid construct comprising a genetic engineered heterogeneous nuclear ribonucleoprotein (hnRNP) A1 gene is provided. A transgenic mouse in which the expression of hnRNP A1 gene has been disrupted is also provided. The mouse is useful for studying the role of hnRNP A1 gene in normal and disease states of a developmental disorder and muscular diseases. Therefore, a method of screening a compound for potential use in prevention and/or treatment of developmental disorder and muscular diseases is further provided.Type: GrantFiled: November 27, 2013Date of Patent: February 3, 2015Assignee: Kaohsiung Medical UniversityInventors: Yung-Fu Chang, Ting-Yuan Liu, Yuh-Jyh Jong, Jan-Gowth Chang
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Publication number: 20140123329Abstract: A nucleic acid construct comprising a genetic engineered heterogeneous nuclear ribonucleoprotein (hnRNP) A1 gene is provided. A transgenic mouse in which the expression of hnRNP A1 gene has been disrupted is also provided. The mouse is useful for studying the role of hnRNP A1 gene in normal and disease states of a developmental disorder and muscular diseases. Therefore, a method of screening a compound for potential use in prevention and/or treatment of developmental disorder and muscular diseases is further provided.Type: ApplicationFiled: November 27, 2013Publication date: May 1, 2014Applicant: KAOHSIUNG MEDICAL UNIVERSITYInventors: Yung-Fu Chang, Ting-Yuan Liu, Yuh-Jyh Jong, Jan-Gowth Chang
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Publication number: 20130067605Abstract: A nucleic acid construct comprising a genetic engineered heterogeneous nuclear ribonucleoprotein (hnRNP) A1 gene is provided. A transgenic mouse in which the expression of hnRNP A1 gene has been disrupted is also provided. The mouse is useful for studying the role of hnRNP A1 gene in normal and disease states of a neurodegenerative disease or a cancer for developing therapies to treat any of these diseases. Therefore, a method of screening a compound for potential use in prevention and/or treatment of neurodegenerative disease or cancer is further provided.Type: ApplicationFiled: August 31, 2012Publication date: March 14, 2013Applicant: KAOHSIUNG MEDICAL UNIVERSITYInventors: Yung-Fu Chang, Ting-Yuan Liu, Yuh-Jyh Jong, Jan-Gowth Chang
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Publication number: 20120214860Abstract: The present invention relates to a method of regulating the expression level of survival of motor neuron 1 (SMN1) comprising administering to a subject in need thereof a therapeutically effective amount of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) regulator and a pharmaceutically acceptable carrier. The present invention also relates to a method of detecting enzyme activity of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) in human fibroblasts comprising detecting protein expression level of survival of motor neuron 1 (SMN1).Type: ApplicationFiled: February 23, 2011Publication date: August 23, 2012Applicant: KAOHSIUNG MEDICAL UNIVERSISTYInventors: Yuh-Jyh Jong, Shih-Hsien Hsu, Jan-Gowth Chang
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Publication number: 20120196290Abstract: A method for diagnosing spinal muscular atrophy is provided. The method includes providing a biological sample of a subject containing a nucleotide of SMN gene, amplifying SMN exons 1, 2a, 2b, 3, 4, 5, 6, 7, and 8 by a universal multiplex PCR using the nucleotide as a template and the primers to obtain fragments of the SMN exons 1, 2a, 2b, 3, 4, 5, 6, 7, and 8, labeling the fragments of the SMN exons 1, 2a, 2b, 3, 4, 5, 6, 7, and 8 by a fluorescent primer to obtain fluorescence-labeled exon fragments, and analyzing the fluorescence-labeled exon fragments by a capillary electrophoresis under a optimized separation condition. If the SMN1/SMN2 ratios in exon 7 and 8 are different, it indicates that the subject is susceptible to spinal muscular atrophy. Additionally, if the peak of certain exon fragment appears crossed, it indicates an intragenic mutation in the exon.Type: ApplicationFiled: January 27, 2011Publication date: August 2, 2012Applicant: KAOHSIUNG MEDICAL UNIVERSITYInventors: SHOU-MEI WU, CHUN-CHI WANG, JAN-GOWTH CHANG, YUH-JYH JONG
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Patent number: 8067568Abstract: A method for diagnosing spinal muscular atrophy is provided. The method includes providing a biological sample of a subject containing a nucleotide of SMN gene, amplifying SMN exons 1, 2a, 2b, 3, 4, 5, 6, 7, and 8 by a universal multiplex PCR using the nucleotide as a template and the primers to obtain fragments of the SMN exons 1, 2a, 2b, 3, 4, 5, 6, 7, and 8, labeling the fragments of the SMN exons 1, 2a, 2b, 3, 4, 5, 6, 7, and 8 by a fluorescent primer to obtain fluorescence-labeled exon fragments, and analyzing the fluorescence-labeled exon fragments by a capillary electrophoresis. If the SMN1/SMN2 ratios in exon 7 and 8 are different, it indicates that the subject is susceptible to spinal muscular atrophy. Additionally, if the peak of certain exon fragment appears crossed, it indicates an intragenic mutation in the exon.Type: GrantFiled: October 24, 2010Date of Patent: November 29, 2011Assignee: Kaohsiung Medical UniversityInventors: Shou-Mei Wu, Chun-Chiu Wang, Jan-Gowth Chang, Yuh-Jyh Jong
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Publication number: 20110033861Abstract: A method for diagnosing spinal muscular atrophy is provided. The method includes providing a biological sample of a subject containing a nucleotide of SMN gene, amplifying SMN exons 1, 2a, 2b, 3, 4, 5, 6, 7, and 8 by a universal multiplex PCR using the nucleotide as a template and the primers to obtain fragments of the SMN exons 1, 2a, 2b, 3, 4, 5, 6, 7, and 8, labeling the fragments of the SMN exons 1, 2a, 2b, 3, 4, 5, 6, 7, and 8 by a fluorescent primer to obtain fluorescence-labeled exon fragments, and analyzing the fluorescence-labeled exon fragments by a capillary electrophoresis. If the SMN1/SMN2 ratios in exon 7 and 8 are different, it indicates that the subject is susceptible to spinal muscular atrophy. Additionally, if the peak of certain exon fragment appears crossed, it indicates an intragenic mutation in the exon.Type: ApplicationFiled: October 24, 2010Publication date: February 10, 2011Applicant: KAOHSIUNG MEDICAL UNIVERSITYInventors: Shou-Mei Wu, Chun-Chiu Wang, Jan-Gowth Chang, Yuh-Jyh Jong
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Patent number: 7875432Abstract: A method for diagnosing spinal muscular atrophy is provided. The method includes providing a biological sample of a subject containing a nucleotide of SMN gene, amplifying SMN exons 1, 2a, 2b, 3, 4, 5, 6, 7, and 8 by a universal multiplex PCR using the nucleotide as a template and the primers to obtain fragments of the SMN exons 1, 2a, 2b, 3, 4, 5, 6, 7, and 8, labeling the fragments of the SMN exons 1, 2a, 2b, 3, 4, 5, 6, 7, and 8 by a fluorescent primer to obtain fluorescence-labeled exon fragments, and analyzing the fluorescence-labeled exon fragments by a capillary electrophoresis. If the SMN1/SMN2 ratios in exon 7 and 8 are different, it indicates that the subject is susceptible to spinal muscular atrophy. Additionally, if the peak of certain exon fragment appears crossed, it indicates an intragenic mutation in the exon.Type: GrantFiled: July 6, 2009Date of Patent: January 25, 2011Assignee: Kaohsiung Medical UniversityInventors: Shou-Mei Wu, Chun-Chiu Wang, Jan-Gowth Chang, Yuh-Jyh Jong
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Publication number: 20100233688Abstract: A method for diagnosing spinal muscular atrophy is provided. The method includes providing a biological sample of a subject containing a nucleotide of SMN gene, amplifying SMN exons 1, 2a, 2b, 3, 4, 5, 6, 7, and 8 by a universal multiplex PCR using the nucleotide as a template and the primers to obtain fragments of the SMN exons 1, 2a, 2b, 3, 4, 5, 6, 7, and 8, labeling the fragments of the SMN exons 1, 2a, 2b, 3, 4, 5, 6, 7, and 8 by a fluorescent primer to obtain fluorescence-labeled exon fragments, and analyzing the fluorescence-labeled exon fragments by a capillary electrophoresis. If the SMN1/SMN2 ratios in exon 7 and 8 are different, it indicates that the subject is susceptible to spinal muscular atrophy. Additionally, if the peak of certain exon fragment appears crossed, it indicates an intragenic mutation in the exon.Type: ApplicationFiled: July 6, 2009Publication date: September 16, 2010Applicant: KAOHSIUNG MEDICAL UNIVERSITYInventors: Shou-Mei Wu, Chun-Chiu Wang, Jan-Gowth Chang, Yuh-Jyh Jong
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Patent number: 6573300Abstract: The invention features a method of modulating SMN exon 7 expression in a subject by administering hydroxyurea to the subject.Type: GrantFiled: August 24, 2001Date of Patent: June 3, 2003Assignee: China Medical College HospitalInventors: Jan-Gowth Chang, Yuh-Jyh Jong, Fuu-Jen Tsai
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Publication number: 20030040543Abstract: The invention features a method of modulating SMN exon 7 expression in a subject by administering hydroxyurea to the subject.Type: ApplicationFiled: August 24, 2001Publication date: February 27, 2003Inventors: Jan-Gowth Chang, Yuh-Jyh Jong, Fuu-Jen Tsai