Patents by Inventor Yuhan Lee
Yuhan Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240131053Abstract: This disclosure relates to compositions including formulated sucralfate or other aluminum-crosslinked sulfated agents for delivery of agents to biological surfaces and/or the modulation of nutrient absorption through the intestinal lining as well as methods for the manufacture of and the use of these compositions for treating disorders including diabetes type II and clinical obesity that require a modulation of certain nutrients to the body.Type: ApplicationFiled: April 26, 2023Publication date: April 25, 2024Inventors: Jeffrey M. Karp, Yuhan Lee, Ali Tavakkoli, Tarawatie E. Deelman
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Publication number: 20230310314Abstract: Compositions formulated for release within the gastrointestinal tract and related methods are discussed. The composition may include a mucoadhesive agent and an active agent. The composition may be formulated for release of the active agent in a first direction while inhibiting release of the active agent in a second direction opposite the first direction.Type: ApplicationFiled: February 27, 2023Publication date: October 5, 2023Applicant: AltrixBio, Inc.Inventors: Yuhan LEE, Shardool JAIN, Jeffrey KARP, Ali TAVAKKOLI
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Publication number: 20230211045Abstract: An implantable, autonomously growing medical device is disclosed. The device may have an outer, braided outer element that holds an inner core. Degradation and/or softening of the inner core permits the outer element to elongate, allowing the device to grow with surrounding tissue. The growth profile of the medical device can be controlled by altering the shape/material/cure conditions of the inner core, as well as the geometry of the out element.Type: ApplicationFiled: September 1, 2022Publication date: July 6, 2023Applicants: Children's Medical Center Corporation, The Brigham and Women's Hospital, Inc.Inventors: Eric N. Feins, Pedro J. del Nido, Nikolay V. Vasilyev, Haruo Yamauchi, Douglas P. Perrin, Peter E. Hammer, Veaceslav Arabagi, Jeffrey M. Karp, Yuhan Lee, Eoin D. O'Cearbhaill
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Publication number: 20230190594Abstract: Compositions comprising personal care products are described. The composition may include a gel-like material and one or more personal care products enclosed within and/or integrated into the gel-like material. The composition may be used to deliver a personal care product by applying compression force to the composition to release the personal care product from the gel-like material.Type: ApplicationFiled: May 26, 2021Publication date: June 22, 2023Inventors: Yuhan LEE, Allison Quinn DIVINCENZO, Jeffrey Michael KARP, Irena BARBULOVIC-NAD, Bryce William CUSHING
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Patent number: 11666597Abstract: This disclosure relates to compositions including formulated sucralfate or other aluminum-crosslinked sulfated agents for delivery of agents to biological surfaces and/or the modulation of nutrient absorption through the intestinal lining as well as methods for the manufacture of and the use of these compositions for treating disorders including diabetes type II and clinical obesity that require a modulation of certain nutrients to the body.Type: GrantFiled: July 28, 2022Date of Patent: June 6, 2023Assignee: The Brigham and Women's Hospital, Inc.Inventors: Jeffrey M. Karp, Yuhan Lee, Ali Tavakkoli, Tarawatie E. Deelman
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Publication number: 20230141842Abstract: This disclosure relates to compositions including formulated sucralfate or other aluminum-crosslinked sulfated agents for the modulation of nutrient absorption through the intestinal lining as well as methods for the manufacture of and the use of these compounds for treating disorders requiring a modulation of certain nutrients to the body including diabetes type II and clinical obesity.Type: ApplicationFiled: November 9, 2022Publication date: May 11, 2023Inventors: Jeffrey M. Karp, Yuhan Lee, Ali Tavakkoli, Tarawatie E. Deelman
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Patent number: 11627949Abstract: An insertable catheter device includes a shaft including a proximal end and a distal end, an expandable balloon, and an actuator configured to expand and retract the expandable balloon. The actuator includes a fluid conduit that extends through the shaft and is coupled with the expandable balloon to enable inflation and retraction of the expandable balloon via injection or withdrawal of a fluid to or from the expandable balloon via the fluid conduit. The expandable balloon is displaceably retractable into the shaft and extendable from the shaft. A fluid pump is coupled with the fluid conduit to pump the fluid through the fluid conduit. A patch is positioned to be displaced by the expandable balloon when the expandable balloon is inflated, and the expandable balloon is displaceably retractable into the shaft and displaceably extendable from the shaft.Type: GrantFiled: February 4, 2020Date of Patent: April 18, 2023Assignees: President and Fellows of Harvard College, The Brigham and Women's Hospital, Children's Medical Center Corporation, Massachusetts Institute of TechnologyInventors: Conor J. Walsh, Ellen T. Roche, Panagiotis Polygerinos, Lucia R. Schuster, Jeffrey Michael Karp, Yuhan Lee, Pedro J. del Nido, Assunta Fabozzo, Ingeborg Friehs, Steven Charles Wasserman
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Patent number: 11524024Abstract: This disclosure relates to compositions including formulated sucralfate or other aluminum-crosslinked sulfated agents for the modulation of nutrient absorption through the intestinal lining as well as methods for the manufacture of and the use of these compounds for treating disorders requiring a modulation of certain nutrients to the body including diabetes type II and clinical obesity.Type: GrantFiled: June 2, 2020Date of Patent: December 13, 2022Assignee: The Brigham and Women's Hospital, Inc.Inventors: Jeffrey M. Karp, Yuhan Lee, Ali Tavakkoli, Tarawatie E. Deelman
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Publication number: 20220362285Abstract: This disclosure relates to compositions including formulated sucralfate or other aluminum-crosslinked sulfated agents for delivery of agents to biological surfaces and/or the modulation of nutrient absorption through the intestinal lining as well as methods for the manufacture of and the use of these compositions for treating disorders including diabetes type II and clinical obesity that require a modulation of certain nutrients to the body.Type: ApplicationFiled: July 28, 2022Publication date: November 17, 2022Inventors: Jeffrey M. Karp, Yuhan Lee, Ali Tavakkoli, Tarawatie E. Deelman
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Patent number: 11433161Abstract: An implantable, autonomously growing medical device is disclosed. The device may have an outer, braided outer element that holds an inner core. Degradation and/or softening of the inner core permits the outer element to elongate, allowing the device to grow with surrounding tissue. The growth profile of the medical device can be controlled by altering the shape/material/cure conditions of the inner core, as well as the geometry of the out element.Type: GrantFiled: January 11, 2021Date of Patent: September 6, 2022Assignees: Children's Medical Center Corporation, The Brigham and Women's Hospital, Inc.Inventors: Eric N. Feins, Pedro J. del Nido, Nikolay V. Vasilyev, Haruo Yamauchi, Douglas P. Perrin, Peter E. Hammer, Veaceslav Arabagi, Jeffrey M. Karp, Yuhan Lee, Eoin D. O'Cearbhaill
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Patent number: 11433094Abstract: This disclosure relates to compositions including formulated sucralfate or other aluminum-crosslinked sulfated agents for delivery of agents to biological surfaces and/or the modulation of nutrient absorption through the intestinal lining as well as methods for the manufacture of and the use of these compositions for treating disorders including diabetes type II and clinical obesity that require a modulation of certain nutrients to the body.Type: GrantFiled: April 12, 2021Date of Patent: September 6, 2022Assignee: The Brigham and Women's Hospital, Inc.Inventors: Jeffrey M. Karp, Yuhan Lee, Ali Tavakkoli, Tarawatie E. Deelman
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Publication number: 20220226475Abstract: This disclosure relates to compositions including formulated sucralfate or other aluminum-crosslinked sulfated agents and one or more biologically active substances to mucosal surfaces within the GI tract and methods for the manufacture and the use of these compositions.Type: ApplicationFiled: June 10, 2019Publication date: July 21, 2022Inventors: Yuhan Lee, Ali Tavakkoli, Jeffrey M. Karp
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Publication number: 20210236538Abstract: This disclosure relates to compositions including formulated sucralfate or other aluminum-crosslinked sulfated agents for delivery of agents to biological surfaces and/or the modulation of nutrient absorption through the intestinal lining as well as methods for the manufacture of and the use of these compositions for treating disorders including diabetes type II and clinical obesity that require a modulation of certain nutrients to the body.Type: ApplicationFiled: April 12, 2021Publication date: August 5, 2021Inventors: Jeffrey M. Karp, Yuhan Lee, Ali Tavakkoli, Tarawatie E. Deelman
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Publication number: 20210205492Abstract: An implantable, autonomously growing medical device is disclosed. The device may have an outer, braided outer element that holds an inner core. Degradation and/or softening of the inner core permits the outer element to elongate, allowing the device to grow with surrounding tissue. The growth profile of the medical device can be controlled by altering the shape/material/cure conditions of the inner core, as well as the geometry of the out element.Type: ApplicationFiled: January 11, 2021Publication date: July 8, 2021Applicants: Children's Medical Center Corporation, The Brigham and Women's Hospital, Inc.Inventors: Eric N. Feins, Pedro J. del Nido, Nikolay V. Vasilyev, Haruo Yamauchi, Douglas P. Perrin, Peter E. Hammer, Veaceslav Arabagi, Jeffrey M. Karp, Yuhan Lee, Eoin D. O'Cearbhaill
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Patent number: 10973846Abstract: This disclosure relates to compositions including formulated sucralfate or other aluminum-crosslinked sulfated agents for delivery of agents to biological surfaces and/or the modulation of nutrient absorption through the intestinal lining as well as methods for the manufacture of and the use of these compositions for treating disorders including diabetes type II and clinical obesity that require a modulation of certain nutrients to the body.Type: GrantFiled: September 26, 2016Date of Patent: April 13, 2021Assignee: The Brigham and Women's Hospital, Inc.Inventors: Jeffrey M. Karp, Yuhan Lee, Ali Tavakkoli, Tarawatie E. Deelman
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Patent number: 10905795Abstract: An implantable, autonomously growing medical device is disclosed. The device may have an outer, braided outer element that holds an inner core. Degradation and/or softening of the inner core permits the outer element to elongate, allowing the device to grow with surrounding tissue. The growth profile of the medical device can be controlled by altering the shape/material/cure conditions of the inner core, as well as the geometry of the outer element.Type: GrantFiled: February 16, 2017Date of Patent: February 2, 2021Assignees: Children's Medical Center Corporation, The Brigham and Women's Hospital, Inc.Inventors: Eric N. Feins, Pedro J. del Nido, Nikolay V. Vasilyev, Haruo Yamauchi, Douglas P. Perrin, Peter Hammer, Veaceslav Arabagi, Jeffrey M. Karp, Yuhan Lee, Eoin D. O'Cearbhaill
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Publication number: 20200289546Abstract: This disclosure relates to compositions including formulated sucralfate or other aluminum-crosslinked sulfated agents for the modulation of nutrient absorption through the intestinal lining as well as methods for the manufacture of and the use of these compounds for treating disorders requiring a modulation of certain nutrients to the body including diabetes type II and clinical obesity.Type: ApplicationFiled: June 2, 2020Publication date: September 17, 2020Inventors: Jeffrey M. Karp, Yuhan Lee, Ali Tavakkoli, Tarawatie E. Deelman
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Patent number: 10716802Abstract: This disclosure relates to compositions including formulated sucralfate or other aluminum-crosslinked sulfated agents for the modulation of nutrient absorption through the intestinal lining as well as methods for the manufacture of and the use of these compounds for treating disorders requiring a modulation of certain nutrients to the body including diabetes type II and clinical obesity.Type: GrantFiled: March 13, 2014Date of Patent: July 21, 2020Assignee: The Brigham and Women's Hospital, Inc.Inventors: Jeffrey M. Karp, Yuhan Lee, Ali Tavakkoli, Tarawatie E. Deelman
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Publication number: 20200179050Abstract: An insertable catheter device includes a shaft including a proximal end and a distal end, an expandable balloon, and an actuator configured to expand and retract the expandable balloon. The actuator includes a fluid conduit that extends through the shaft and is coupled with the expandable balloon to enable inflation and retraction of the expandable balloon via injection or withdrawal of a fluid to or from the expandable balloon via the fluid conduit. The expandable balloon is displaceably retractable into the shaft and extendable from the shaft. A fluid pump is coupled with the fluid conduit to pump the fluid through the fluid conduit. A patch is positioned to be displaced by the expandable balloon when the expandable balloon is inflated, and the expandable balloon is displaceably retractable into the shaft and displaceably extendable from the shaft.Type: ApplicationFiled: February 4, 2020Publication date: June 11, 2020Applicants: President and Fellows of Harvard College, The Brigham and Women's Hospital, Children's Medical Center Corporation, Massachusetts Institute of TechnologyInventors: Conor J. Walsh, Ellen T. Roche, Panagiotis Polygerinos, Lucia R. Schuster, Jeffrey Michael Karp, Yuhan Lee, Pedro J. del Nido, Assunta Fabozzo, Ingeborg Friehs, Steven Charles Wasserman
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Patent number: 10588695Abstract: An insertable light-dispensing catheter device, comprising a shaft including a proximal and distal end, a light guide extending through the shaft, and a mirror displaceably extendable from the catheter into a position where the mirror receives and reflects light emitted from the light guide. The mirror can be in the form of a coating on an inflatable balloon; and the balloon, when inflated, can press a patch against a defect (e.g., a ventricular septical defect), while the light cures an adhesive that binds the patch to the structure with the defect, thereby remedying the defect.Type: GrantFiled: May 13, 2015Date of Patent: March 17, 2020Assignees: President and Fellows of Harvard College, The Brigham and Women's Hospital, Children's Medical Center Corporation, Massachusetts Institute of TechnologyInventors: Conor J. Walsh, Ellen T. Roche, Panagiotis Polygerinos, Lucia R. Schuster, Jeffrey Michael Karp, Yuhan Lee, Pedro J. del Nido, Assunta Fabozzo, Ingeborg Friehs, Steven Charles Wasserman