Patents by Inventor Yuichiro Hashimoto
Yuichiro Hashimoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11955327Abstract: The present invention implements an ion detector with which it is possible to avoid direct collisions of negative ions with a scintillator, prevent degradation of the scintillator, prolong life of the scintillator, reduce the need for maintenance, and perform highly sensitive detection of both positive and negative ions. With respect to a reference line 65 connecting a central point 63 of a positive ion CD 52 and a central point 64 of a counter electrode 54, a central point 66 of a negative ion CD 53 is provided in a region of a side opposite to a region of a side of a central point 67 of a scintillator 56. Positive ions entering from an ion entrance 62 receive a deflection force and collide with the positive ion CD 52 to generate secondary electrons. The generated secondary electrons collide with the scintillator 56 to generate light. The generated light passes through a light guide 59 and is detected by a photomultiplier tube 58. A negative potential barrier is generated along the reference line 65.Type: GrantFiled: January 22, 2020Date of Patent: April 9, 2024Assignee: Hitachi High-Tech CorporationInventors: Kiyomi Yoshinari, Masuyuki Sugiyama, Yuichiro Hashimoto, Shin Imamura
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Publication number: 20240094236Abstract: A flow path washing method and apparatus for an auto sampler in which, when a cleaning fluid supplied to a flow path which is switched between a first flow path including a nozzle for aspirating a sample and a sample loop for holding the aspirated sample, and a second flow path including a washing tub for washing at least an outer wall of the nozzle, a control unit changes a flow velocity of the cleaning fluid supplied between measurement of a first measurement item and measurement of a second measurement item based on washing information showing washing patterns corresponding to measurement items of the sample, including at least one of first washing information showing a washing pattern corresponding to the first measurement item of the sample and second washing information showing a washing pattern corresponding to the second measurement item to be measured subsequent to the first measurement item.Type: ApplicationFiled: December 10, 2021Publication date: March 21, 2024Inventors: Yushi HARADA, Yuichiro HASHIMOTO
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Publication number: 20240060942Abstract: Provided is an analyzer column cartridge that can control the temperature of an analysis column while saving resources and costs. An analyzer column cartridge 1 includes: metal blocks 7, 8 that accommodate an analysis column 10 used in a liquid chromatography; and housings 2, 3 that accommodate the metal blocks 7, 8. A plurality of holes 11A, 11B, 11C, 11D, and 11E that communicate with an accommodation space of the analysis column 10 are formed in the metal block 8. The housing has a plurality of windows 6A, 6B, 6C, 6D, and 6E formed at positions facing the plurality of holes 11A, 11B, 11C, 11D, and 11E formed in the metal block 8.Type: ApplicationFiled: December 7, 2021Publication date: February 22, 2024Applicant: HITACHI HIGH-TECH CORPORATIONInventors: Yusuke Shimizu, Yoshito Watanabe, Yu Iijima, Shuhei Yamamura, Yuichiro Hashimoto
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Publication number: 20240063010Abstract: A mass spectrometry device can reduce a deviation in a mass axis due to the generation of heat from an AC voltage control circuit; and a method for controlling the mass spectrometry device. The mass spectrometry device has a quadrupole electrode, to which a controlled AC voltage is applied, and uses the quadrupole electrode as a mass filter. Before measurement, the mass spectrometry device applies an AC voltage of a prescribed amplitude V1 to the multipole electrode for a prescribed time T1, and a heating value J1 that is generated when the AC voltage of the prescribed amplitude V1 is applied to the multipole electrode for the prescribed time T1 is equivalent to a heating value that is generated when the AC voltage of the amplitude that is applied during the measurement is applied until a thermally steady state is reached (see FIG. 3A).Type: ApplicationFiled: January 17, 2022Publication date: February 22, 2024Inventors: Yuka SUGAWARA, Yuichiro HASHIMOTO, Hiroyuki YASUDA, Masuyuki SUGIYAMA, Riku TAMURA
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Publication number: 20240006174Abstract: A method for controlling a mass spectrometer capable of identifying an abnormal location in a device is provided. A method for controlling a mass spectrometer including an ion source that ionizes a compound in a sample, a mass spectrometry unit that separates ions based on a mass-to-charge ratio, and a plurality of electrodes that form an electric field that transports ions generated by the ion source to the mass spectrometry unit includes ionizing the sample by the ion source, detecting, based on a change in ion permeability over time, ions accumulated in the electrodes and quadrupole mass filters forming the mass spectrometry unit, and detecting a change in ionization efficiency of the ion source based on a change in an amount of ions with respect to a gas flow rate for the ion source or a voltage of the ion source.Type: ApplicationFiled: December 17, 2021Publication date: January 4, 2024Inventors: Riku TAMURA, Hiroyuki YASUDA, Yuka SUGAWARA, Yuichiro HASHIMOTO
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Patent number: 11860142Abstract: A liquid chromatograph mass spectrometer specifying a location where a flow path is clogged and recovering in a short time. The liquid chromatograph mass spectrometer includes a first flow path passing through a separation column, a second flow path not passing through the separation column, a mass spectrometry unit on the downstream side of the first and second flow paths that analyzes a sample that has passed through the first flow path, a first valve for connecting any one of the first and second flow paths to the mass spectrometry unit, and a controller for controlling driving of the first valve connecting the first flow path to the mass spectrometric unit, comparing the measured value of the mass spectrometric unit with a predetermined threshold value, and connecting the second flow path to the mass spectrometry unit when it is determined to be abnormal.Type: GrantFiled: October 25, 2019Date of Patent: January 2, 2024Assignee: HITACHI HIGH-TECH CORPORATIONInventors: Masuyuki Sugiyama, Yuichiro Hashimoto, Hideki Hasegawa
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Publication number: 20230408459Abstract: Provided is an autosampler of a liquid chromatograph that can manage a sample container even in a case where the throughput of a pretreatment unit exceeds the throughput of the autosampler. An autosampler of a liquid chromatograph includes a plurality of sample aspiration nozzles that aspirates a sample from sample containers installed at respective sample aspiration points; a sample transfer means that transfers the sample containers to the respective sample aspiration points; and a retraction point where one of the sample containers is put into the autosampler and one of the sample containers collected from the sample aspiration points can be held.Type: ApplicationFiled: December 8, 2021Publication date: December 21, 2023Applicant: HITACHI HIGH-TECH CORPORATIONInventors: Daisuke Kanai, Yuichiro Hashimoto
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Publication number: 20230384271Abstract: Provided is a technology for reducing the capacity of a liquid feeding pump and enabling liquid feeding with little pulsation. A liquid feeding pump according to the present disclosure is provided with: a first plunger pump having a first plunger; a second plunger pump having a second plunger and connected in series with the first plunger pump; a pressure sensor disposed downstream of the second plunger pump; and a control unit that accepts the input of a liquid discharge pressure measured by the pressure sensor and that controls the driving of the first plunger and the driving of the second plunger.Type: ApplicationFiled: October 12, 2021Publication date: November 30, 2023Inventors: Nobuhiro TSUKADA, Daisuke AKIEDA, Sho IWASA, Yusuke YOTA, Yuichiro HASHIMOTO
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Publication number: 20230332586Abstract: The present invention provides a technique that enables liquid feeding with small pulsation by reducing the volume of a liquid feeding pump. Disclosed is a liquid feeding pump comprising: a first plunger pump that has a first plunger; a second plunger pump that has a second plunger and is connected to the first plunger pump in series; a pressure sensor that is disposed on the downstream side of the second plunger pump; and a control unit that accepts an input of the discharge pressure of a liquid measured by the pressure sensor to control driving of the first plunger and driving of the second plunger, wherein when the first plunger pump compresses the liquid, the control unit drives the first plunger at a first speed, and then decreases the speed to a second speed slower than the first speed before the compression is completed, and wherein the control unit discharges the liquid from the second plunger pump by driving the second plunger in parallel with the driving of the first plunger.Type: ApplicationFiled: November 5, 2020Publication date: October 19, 2023Inventors: Nobuhiro TSUKADA, Daisuke AKIEDA, Yuichiro HASHIMOTO, Sho IWASA, Yusuke YOTA
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Patent number: 11749517Abstract: An object of the present invention is to improve the safety and stability of an ion source by making a temperature distribution of a heated gas uniform while ensuring heat insulating properties. The ion source according to the present invention includes a gas introduction port inside a probe holder that holds an ion probe. A heater that increases the temperature of a heated gas and the gas introduction port are connected by a plurality of pipes which extend along an extending direction of the ion probe and are independent of each other (see FIG. 4).Type: GrantFiled: October 10, 2019Date of Patent: September 5, 2023Assignee: HITACHI HIGH-TECH CORPORATIONInventors: Hideki Hasegawa, Masuyuki Sugiyama, Yuichiro Hashimoto
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Publication number: 20230184802Abstract: A control method for an automatic analyzer that can improve robustness, throughput, and measurement accuracy. The automatic analyzer includes a sample loop connected between two sample ports of a plurality of sample ports of a switch valve. The method includes the steps of: adjusting a drive parameter of the syringe corresponding to a viscosity of the sample acquired in advance; switching the switch valve to a first state in which the sipper and the syringe contact with each other without through the sample loop; driving the syringe based on the drive parameter to draw and introduce the sample through the sipper; switching the switch valve to a second state in which the syringe and the sample loop conduct with each other; and driving the syringe based on the drive parameter to introduce the sample into the sample loop.Type: ApplicationFiled: May 19, 2021Publication date: June 15, 2023Inventors: Makoto NOGAMI, Yushi HARADA, Yuichiro HASHIMOTO
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Publication number: 20230170198Abstract: A mass spectrometer includes an ion source, an ion guide, a quadrupole mass filter, a detector, DC and RF power sources, and a voltage control device for controlling an acceleration voltage by controlling the power source. The voltage controller controls the acceleration voltage such that it is increased as the mass-to-charge ratio of ions to be measured is increased within a control region. The control region is surrounded, having one coordinate axis representing the mass-to-charge ratio of the ions passing the ion guide and another axis representing the acceleration voltage applied to the ion guide, by a line representing a lower limit of a stable region where the ions pass the ion guide stably, a line representing an ion mobility of the ions, an upper side representing an upper limit of the acceleration voltage, and a lower side representing a value at which the acceleration voltage is zero.Type: ApplicationFiled: March 23, 2021Publication date: June 1, 2023Applicant: Hitachi High-Tech CorporationInventors: Masuyuki SUGIYAMA, Hideki HASEGAWA, Yuki NAGAYA, Yuichiro HASHIMOTO, Hiroyuki YASUDA
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Publication number: 20230141083Abstract: There are provided an ion source that can accurately and efficiently grasp whether a tip end position on a capillary downstream side is proper and a control method therefor. An ion source according to an embodiment of the present invention measures an electric current generated due to the application of a voltage to a capillary by a power supply when a sample is not introduced into the capillary. When the electric current is within tolerance, the ion source outputs projection amount information expressing that the projection amount of the capillary is proper, and the ion source outputs the projection amount information expressing that the projection amount is improper when the projection amount is not within the tolerance.Type: ApplicationFiled: December 4, 2020Publication date: May 11, 2023Inventors: Hideki HASEGAWA, Masuyuki SUGIYAMA, Yuichiro HASHIMOTO
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Publication number: 20230136178Abstract: To provide a mass spectrometer for higher ion permeation efficiency. In a mass spectrometer to transfer ions generated in an ion source 101 to a detector 106 through a vacuum chamber equipped with electrodes, the vacuum chamber includes a first vacuum chamber 107 and a second vacuum chamber 108 communicated by a pore 104 and an air flow containing ions introduced from the ion source 101 into the first vacuum chamber 107 is separated to an air flow 704 and an ion flow 703 by an ion guide 103 in the first vacuum chamber 107. The first vacuum chamber 107 has a current plate 113 to reduce mixing of the separated air flow 704 and ion flow 703.Type: ApplicationFiled: February 10, 2021Publication date: May 4, 2023Inventors: Yuka SUGAWARA, Masuyuki SUGIYAMA, Yuichiro HASHIMOTO, Hiroyuki YASUDA, Riku TAMURA
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Patent number: 11635413Abstract: The invention provides a liquid chromatograph mass spectrometer which prevents contamination of a pump and a column and can perform mass calibration without adding a complicated mechanism. This liquid chromatograph mass spectrometer includes a liquid chromatograph including a liquid feed pump configured to feed a mobile phase solvent, a mass spectrometer configured to analyze a mass of a sample, and a standard sample container configured to be connected in series with the liquid chromatograph and the mass spectrometer in a flow path that connects the liquid chromatograph and the mass spectrometer and configured to house a standard sample for mass calibration.Type: GrantFiled: February 4, 2020Date of Patent: April 25, 2023Assignee: HITACHI HIGH-TECH CORPORATIONInventors: Yuka Sumigama, Yuichiro Hashimoto
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Publication number: 20230123459Abstract: A liquid chromatographic apparatus which removes air bubbles during preparatory operation for apparatus startup which includes a liquid feeding pump to feed a solvent, an injector to inject a sample into the solvent, a separation column to receive the solvent and the sample through the injector and separate the sample into components, a detector to detect the components supplied from the separation column, a pressure sensor to measure a pressure in a solvent flow channel of the liquid feeding pump, and a controller to control a purge operation for removing air bubbles in the solvent flow channel by the liquid feeding pump, judges whether a pressure change amount in the solvent flow channel measured by the pressure sensor during the purge operation is a specified change amount or larger, and completes the air bubble removal operation when the pressure change amount is the specified change amount or larger.Type: ApplicationFiled: March 5, 2021Publication date: April 20, 2023Inventors: Midori TOBITA, Yuichiro HASHIMOTO, Nobuhiro TSUKADA
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Publication number: 20230091683Abstract: The present invention relates to a liquid feeding apparatus capable of feeding a liquid with high accuracy. The liquid feeding apparatus includes a liquid feeder having a downstream side, a plunger, and a cylinder that is configured for aspirating and discharging a solvent when a plunger slides. The liquid feeding apparatus further includes a pressure sensor for the solvent to be discharged, a selector valve configured to switch between a plurality of solvents to be aspirated and discharged, and a controller configured to control the liquid feeder and the selector valve. The controller controls the selector valve in synchronization with an aspiration operation of the plunger so that a mixing ratio of the solvents changes, controls the plunger to cause the plunger to operate at first and second accelerations that are different from each other, and suppresses a fluctuation of the solvent to be aspirated by the plunger.Type: ApplicationFiled: March 5, 2021Publication date: March 23, 2023Applicant: HITACHI HIGH-TECH CORPORATIONInventors: Daisuke Akieda, Nobuhiro Tsukada, Yusuke Yota, Yuichiro Hashimoto, Jun Maeda
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Publication number: 20230056978Abstract: In a mass spectrometer, due to impurities accumulated inside a frame, a withstand voltage may decrease, and electric discharge may occur in an ion source, thereby making it impossible to perform normal measurement. Since a result of abnormality measurement due to the electric discharge cannot be distinguished from measurement abnormality caused by clogging of a tube between a pretreatment unit and a needle, there is a problem in that time is required to identify abnormal portions, and a maintenance property is lowered. As a unit for solving the problem, a return current detection unit connected in series between the frame and an ion source power supply that applies a voltage to the needle and a return current detection unit connected in series between the frame and a counter electrode power supply that applies a voltage to a counter electrode are provided.Type: ApplicationFiled: December 2, 2020Publication date: February 23, 2023Applicant: Hitachi High-Tech CorporationInventors: Takuma NISHIMOTO, Zihao ONG, Isao FURUYA, Hiroshi TOUDA, Yuichiro HASHIMOTO, Masuyuki SUGIYAMA
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Publication number: 20230037141Abstract: The present disclosure is related to an analytical system comprising a liquid chromatographic (LC) system comprising a plurality of fluidic streams alternately connectable to a common detector via a stream-selection valve connected to the detector via a valve-to-detector conduit. The analytical system further comprises a wash pump fluidically connected to the stream-selection valve and configured to connect to the valve-to-detector conduit between two consecutive fluidic streams in order to wash liquid from a previous fluidic stream out of the valve-to-detector conduit before liquid from a subsequent fluidic stream enters the valve-to-detector conduit. An analytical method comprising switching between the fluidic streams and washing in between is also disclosed.Type: ApplicationFiled: October 13, 2022Publication date: February 2, 2023Applicants: ROCHE DIAGNOSTICS OPERATIONS, INC., HITACHI HIGH-TECH CORPORATIONInventors: Stefan Quint, Tibor Toth, Aart Pieter Van Doorn, Yuichiro Hashimoto
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Publication number: 20230005730Abstract: Provided are an ion source and a mass spectrometer that reduce a dead volume of the connecting part of a pipe to a capillary. An ion source has a capillary and a pipe. The capillary has a large-diameter part that forms a capillary upstream-side end face on an upstream side. The large-diameter part has a large-diameter part downstream side face on a downstream side. The pipe has a pipe downstream end face on the downstream side. A capillary retaining unit has a hole through which the capillary downstream-side end face is passable and a face on which the large-diameter part downstream side face is installable. The ion source includes a pipe retaining unit that retains the pipe. The capillary retaining unit and the pipe retaining unit are disposed such that the capillary upstream-side end face contacts the pipe downstream end face to connect the capillary to the pipe.Type: ApplicationFiled: October 15, 2020Publication date: January 5, 2023Applicant: Hitachi High-Tech CorporationInventors: Hideki HASEGAWA, Masuyuki SUGIYAMA, Yuichiro HASHIMOTO