Abstract: The present disclosure provides a busbar unit capable of improving the detection accuracy of the temperature of a busbar by a temperature sensor. The busbar unit (10) comprises a busbar (13), a temperature sensor (14), an insulating covering member (7) that is made of resin and covers the busbar (13) and the temperature sensor (14). The temperature sensor (14) has a thermistor element (41) and a case (51) that accommodates the thermistor element (41). The busbar (13) has a sensor holding part (22) that holds the temperature sensor (14). The sensor holding part (22) has a first support part (31) having a first contact surface (31a), a second support part (32) having a second contact surface (32a) facing the first contact surface (31a), and a connection part that connects ends of the first support part (31) and the second support part (32). The sensor holding part (22) holds the temperature sensor (14) by sandwiching the case (51) between the first contact surface (31a) and the second contact surface (32a).

Abstract: The present invention provides a compound represented by formula (I) or a pharmaceutically acceptable salt thereof which has the effect of antagonizing the LPA1 receptor.

Abstract: One aspect of the present disclosure provides a terminal block capable of improving mounting position accuracy. A terminal block according to the one aspect of the present disclosure includes a plate made of metal and to be fixed to a first case made of metal, a housing held on the plate, and a plurality of terminals held in the housing. The plate includes a first positioning hole through which a first positioning pin is inserted.

Abstract: A point which requires visual attention is added to map data. A map data generation device acquires image data in which the outside is captured from a vehicle by an input device and a point data of the vehicle, associates both data, and generates a visual saliency map acquired by estimating fluctuation of visual saliency based on the image data by the visual saliency extraction unit. Then, whether or not a point or a section indicated by position information corresponding to the visual saliency map is a point or a section which requires visual attention is analyzed based on the visual saliency map by an analysis unit, and the point or the section which requires the visual attention is added to the map data based on an analysis result of the analysis unit by an addition device.

Abstract: A sleeve is provided inside a body configuring a channel selector valve, and first and second guide portions with which outer peripheries of first and second land portions of a valve body are in sliding contact are formed on one end side and the other end side of the sleeve. The first and second guide portions are formed to axially overlap with the first and second land portions so as to abut the first and second land portions at all times when the valve body axially moves. The valve body includes a plurality of communicating paths penetrating through the valve body in the axial direction, and, in the sleeve, a first space formed on one end side of the valve body and a second space formed on the other end side of the valve body communicate with each other via the communicating paths.

Abstract: An objective is to provide an Fc-modified antibody or the like having a long serum half-life according to a CCAP method, more specifically, an antibody or the like where IgBP is bound to only one site, based on findings of the inventors. Provided is an objective antibody or the like by purification and production of an Fc-modified antibody or the like with a column bound to an Fc region of an antibody. Specifically, an antibody where only one of two binding sites of Fc is selectively modified is provided by allowing an IgBP-bound antibody produced by a CCAP method to adsorb to a carrier of an IgBP-immobilized column, or forming a state where only one Fc of an antibody is bound to an IgBP binding column and then adding a peptide reagent for CCAP to the column to perform a reaction of a CCAP method in the column.

Abstract: It is an object of the present invention to provide a method for modifying an antibody in a specific and simple manner, and others. The present invention relates to: an IgG-binding peptide, an IgG-binding peptide modified with a crosslinking agent, a complex of an IgG-binding peptide modified with the crosslinking agent and IgG, a method for producing the complex, and others.

Abstract: The present invention provides a compound represented by formula [I] shown below or a pharmaceutically acceptable salt thereof that has an inhibitory effect on 20-HETE producing enzyme.

Abstract: A stirring and defoaming device is a stirring and defoaming device of a revolution and rotation type, wherein a vacuum unit for sucking air in each container to bring the inside of each container into a vacuum state includes sealing bodies that seal respective containers, a vacuum generation source, a suction path running toward a revolution center with each container as a starting end, passing through the revolution center to go outside the system, and reaching the vacuum generation source placed outside the system, at least part of the suction path being an independent path from the starting end in association with each container, and at least two or more vacuum measurement units, each provided in an independent path.

Abstract: A component production method includes: a step of binding a long frame by a plurality of support devices arranged along the frame; a step of measuring, with a distance sensor, a distance to the frame supported by the plurality of support devices; a step in which, based on frame shape data prerecorded in a memory, the support devices move support positions where the frame is supported so that a calculated radial position of the frame being supported by the support devices matches the data about the frame shape; a step of fixing the frame in a state in which the data about the frame shape matches the radial position of the frame; and a step of performing a hole-making operation on the fixed frame.

Abstract: The invention relates to an antibody which binds to myelin oligodendrocyte glycoprotein (MOG), an antibody fragment thereof, a hybridoma which produces the antibody or the antibody fragment, a nucleic acid containing a nucleotide sequence which encodes the antibody or the antibody fragment, a transformant cell containing a vector containing the nucleic acid, a method for producing the antibody or the antibody fragment, a composition containing the antibody or the antibody fragment and a method for detecting or measuring an antigen that is present in the brain, a method for diagnosing or treating a brain disease, a method for improving the property of an antibody of accumulating in the brain and a method for increasing the amount of an antibody in the brain which use the antibody or the antibody fragment.

Abstract: A drive apparatus is provided for driving a multi-phase rotating electric machine. The rotating electric machine includes a plurality of winding groups for respective phases. The drive apparatus includes a first inverter connected with start terminals of the winding groups of the rotating electric machine, a second inverter connected with intermediate terminals of the winding groups, and an energization controller configured to selectively perform energization of the winding groups by the first inverter and energization of the winding groups by the second inverter. Each of the first and second inverters includes a plurality of switch pairs respectively corresponding to the winding groups and each consisting of an upper-arm switch and a lower-arm switch that are connected in series with each other. Moreover, each of the upper-arm and lower-arm switches of the first inverter is configured to have bidirectionally-conducting and bidirectionally-blocking functions.

Abstract: The purpose of the present invention is to provide a solid-phase carrier on which an IgG-binding peptide is immobilized, the peptide being usable for IgG purification, having resistance to repeated washing with an alkaline solution after IgG purification, and having a high binding affinity for IgG. Specifically, the present invention relates to a solid-phase carrier on which an IgG-binding peptide is immobilized, wherein the two cysteine residues on the outside of the peptide are linked as shown in the following formula: (in the formula, the upper cysteine residue is on the N-terminal side of the peptide, and the lower cysteine residue is on the C-terminal side of the peptide).

Abstract: The present invention provides an IgG-binding peptide which can be used for the purification of IgG and has excellent stability, e.g., alkali stability. The present invention also provides a method for purifying IgG using the IgG-binding peptide. Specifically, the present invention relates to a solid-phase support including an IgG-binding peptide, an IgG separation column including the solid-phase support, a kit including the solid-phase support or the column, and a method for purifying IgG using the solid-phase support or the column.

Abstract: An object of the present invention is to provide a method by which a peptide having a specific binding capability that can be used for purification of a target molecule can be produced at a low cost, and specifically relates to a peptide fusion protein including one or more peptides having specific binding capability and a scaffold protein, the peptide being inserted into the amino acid sequence of the scaffold protein directly or via a peptide linker, and/or being linked to the N-terminal and/or C-terminal of the scaffold protein.

Abstract: The invention relates to an antibody which binds to myelin oligodendrocyte glycoprotein (MOG), an antibody fragment thereof, a hybridoma which produces the antibody or the antibody fragment, a nucleic acid containing a nucleotide sequence which encodes the antibody or the antibody fragment, a transformant cell containing a vector containing the nucleic acid, a method for producing the antibody or the antibody fragment, a composition containing the antibody or the antibody fragment and a method for detecting or measuring an antigen that is present in the brain, a method for diagnosing or treating a brain disease, a method for improving the property of an antibody of accumulating in the brain and a method for increasing the amount of an antibody in the brain which use the antibody or the antibody fragment.

Abstract: The present invention relates to a carrier core material for electrophotographic developer, having a ferrite composition and having a supernatant transmittance of 85.0% or more, a method for producing the carrier core material, a carrier for electrophotographic developer, containing the carrier core material, and a developer containing the carrier.

Abstract: The invention relates to an antibody which binds to chondroitin sulfate proteoglycan 5 (CSPG5) or an antibody fragment thereof, a hybridoma which produces the antibody or the antibody fragment thereof, a nucleic acid comprising a nucleotide sequence encoding the antibody or the antibody fragment thereof, a transformant cell comprising a vector comprising the nucleic acid, a method for producing the antibody or the antibody fragment thereof, a composition comprising the antibody or the antibody fragment thereof, and a method for detecting or measuring an antigen present in the brain, a method for diagnosing or treating a brain disease, a method for enhancing the property of accumulating in a brain of an antibody, and a method for increasing the amount of an antibody in the brain, each of which using the antibody or the antibody fragment thereof, and the like.

Abstract: Provision of an affinity carrier using a mutant VHH antibody. An affinity carrier comprising: a solid phase carrier; and an immunoglobulin-binding protein bound to the solid phase carrier; wherein the immunoglobulin-binding protein comprises a mutant VHH antibody or a fragment of the mutant VHH antibody that recognizes an epitope in at least one region selected from the group consisting of amino acids 127 to 184 of SEQ ID NO: 22 and amino acids 13 to 210 of SEQ ID NO: 23.

Abstract: The invention provides a hair cosmetic comprising a novel block copolymer capable of sustainably imparting properties such as slipperiness to hair. The hair cosmetic of the present invention comprises a block copolymer having a hydrophobic segment and a hydrophilic segment, wherein the hydrophobic segment has a monomer unit composed of at least one monomer selected from the following Formula 1 and Formula 2, wherein the hydrophilic segment has a monomer unit composed of a monomer of the following formula 3: where R1 is hydrogen or a methyl group, R2 is hydrogen or fluorine, m is an integer of 1 to 6, and n is an integer of 5 to 15, where R1 is hydrogen or a methyl group, R3 and R4 are each independently an alkyl group having 1 to 6 carbon atoms, m is an integer of 1 to 6, and p is an integer of 5 to 70, where R1 is hydrogen or a methyl group, m is an integer of 1 to 6, and R5 are each independently a functional group that hydrolyzes and cross-links.