Patents by Inventor Yuji Ohki
Yuji Ohki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8642032Abstract: The present invention provides a method for screening a patient to be administered with a pharmaceutical composition which comprises an anti-cancer antibody as an active ingredient, said method comprising collecting samples from patients who expresses an antigen which is recognized by the anti-cancer antibody, measuring cadherin function in the samples, and selecting a patient whose the cadherin function is decreased or deleted; a method for screening a patient who has a high efficacy ratio for a pharmaceutical composition which comprises an anti-cancer antibody as an active ingredient; and a method for improving an efficacy ratio for a pharmaceutical composition which comprises an anti-cancer antibody as an active ingredient.Type: GrantFiled: June 26, 2008Date of Patent: February 4, 2014Assignees: Kyowa Hakko Kirin Co., Ltd., Japan as Represented by President of National Cancer CenterInventors: Takashi Sato, Naoya Kimoto, Yuji Ohki, Akiko Furuya, Hiroyuki Ishida, Atsushi Ochiai
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Patent number: 8093362Abstract: An antibody which binds to a polypeptide encoded by human PERP (p53 apoptosis effector related to PMP-22) gene which is considered to be related to incidence of cancer or the like is desired. The present invention provides a gene recombinant antibody which has no consensus sequence of an N-linked sugar chain in a variable region, specifically recognizes three-dimensional structure of an extracellular region of a polypeptide encoded by the PERP gene and binds to the extracellular region. The antibody is useful for treatment of various diseases expressing a polypeptide encoded by the PERP gene.Type: GrantFiled: December 6, 2006Date of Patent: January 10, 2012Assignees: Kyowa Hakko Kirin Co., Ltd., Japan as Represented by President of National Cancer CenterInventors: Atsushi Ochiai, Emi Hosaka, Kazuyasu Nakamura, Akiko Furuya, Yuji Ohki
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Publication number: 20100189724Abstract: The present invention provides a method for screening a patient to be administered with a pharmaceutical composition which comprises an anti-cancer antibody as an active ingredient, said method comprising collecting samples from patients who expresses an antigen which is recognized by the anti-cancer antibody, measuring cadherin function in the samples, and selecting a patient whose the cadherin function is decreased or deleted; a method for screening a patient who has a high efficacy ratio for a pharmaceutical composition which comprises an anti-cancer antibody as an active ingredient; and a method for improving an efficacy ratio for a pharmaceutical composition which comprises an anti-cancer antibody as an active ingredient.Type: ApplicationFiled: June 26, 2008Publication date: July 29, 2010Applicant: KYOWA HAKKO KIRIN CO., LTD.Inventors: Takashi Sato, Naoya Kimoto, Yuji Ohki, Akiko Furuya, Hiroyuki Ishida, Atsushi Ochian
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Patent number: 7626634Abstract: A camera stand comprising a foot that will be placed a surface, a support having opposite ends at one of which the support is supported rotatably on the foot and turnable between a lying position and an upstanding position, an arm mechanism capable of attaching a digital camera removably at one end thereto and supported rotatably at the other end to the other end of the support such that in use the arm mechanism is adjusted in angle to the support so as to allow the camera to pick up an image of a picture/document placed under the camera while in non-use the arm mechanism is received within the confine of the support, which is then folded on the foot.Type: GrantFiled: August 19, 2004Date of Patent: December 1, 2009Assignee: Casio Computer Co., Ltd.Inventors: Yuji Ohki, Atsushi Shigemura, Masakazu Iwamoto, Shuji Shibuki
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Patent number: 7498415Abstract: It is demanded that pharmaceutical agents for therapeutic treatment of diseases such as cancer, acromegaly and diabetic complications, of which IGF is involved in the progress of the conditions. The present invention provides a recombinant antibody or an antibody fragment thereof which specifically binds to human insulin-like growth factor-I (hereinafter referred to as hIGF-I) and human insulin-like growth factor-II (hereinafter referred to as hIGF-II) to inhibit the biological activities of human IGF-I and human IGF-II, a transformant producing the antibody or the antibody fragment thereof, a process for producing the antibody or the antibody fragment thereof, and a medicament comprising the antibody or the antibody fragment thereof as the active ingredient therein.Type: GrantFiled: September 24, 2004Date of Patent: March 3, 2009Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Kenya Shitara, Kazuyasu Nakamura, Yuji Ohki
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Publication number: 20080267953Abstract: An antibody which binds to a polypeptide encoded by human PERP (p53 apoptosis effector related to PMP-22) gene which is considered to be related to incidence of cancer or the like is desired. The present invention provides a gene recombinant antibody which has no consensus sequence of an N-linked sugar chain in a variable region, specifically recognizes three-dimensional structure of an extracellular region of a polypeptide encoded by the PERP gene and binds to the extracellular region. The antibody is useful for treatment of various diseases expressing a polypeptide encoded by the PERP gene.Type: ApplicationFiled: December 6, 2006Publication date: October 30, 2008Applicants: KYOWA HAKKO KOGYO CO., LTD., Japan as Represented by President of National Cancer CenterInventors: Atsushi Ochiai, Emi Hosaka, Kazuyasu Nakamura, Akiko Furuya, Yuji Ohki
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Patent number: 7438911Abstract: For the effective treatment of diseases such as cancer in which hIGF participates, there have been desired to be developed antibodies which strongly bind to both factors hIGF-I and hIGF-II and inhibit their functions and fragments of these antibodies. The present invention provides antibodies which have the ability to specifically bind to human IGF-I and IGF-II to thereby inhibit the functions of human IGF-I and IGF-II and have binding activity with a binding constant of 5×109 M?1 or more measured with a biosensor BIACORE. In addition, the present invention provides diagnostics, preventives and remedies for an hIGF-mediated disease and a disease showing pathological progressing due to abnormally promoted hIGF production, which use said antibodies.Type: GrantFiled: April 30, 2003Date of Patent: October 21, 2008Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Kenya Shitara, Kazuyasu Nakamura, Akiko Furuya, Rinpei Niwa, Yuji Ohki, Nobuo Hanai
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Publication number: 20060263362Abstract: An object of the present invention is to provide a cancer metastasis inhibitor or, more particularly, a useful pharmaceutical composition for treating of bone metastasis and liver metastasis. In accordance with the invention, a cancer metastasis inhibitor comprising a substance inhibiting the activity of IGF (insulin-like growth factor)-I and IGF-II is an active ingredient is provided. The inhibitor can significantly suppress the metastasis of cancer.Type: ApplicationFiled: August 20, 2004Publication date: November 23, 2006Inventors: Atsushi Ochiai, Kenya Shitara, Kazuyasu Nakamura, Yuji Ohki
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Publication number: 20060240015Abstract: It is demanded that pharmaceutical agents for therapeutic treatment of diseases such as cancer, acromegaly and diabetic complications, of which IGF is involved in the progress of the conditions. The present invention provides a recombinant antibody or an antibody fragment thereof which specifically binds to human insulin-like growth factor-I (hereinafter referred to as hIGF-I) and human insulin-like growth factor-II (hereinafter referred to as hIGF-II) to inhibit the biological activities of human IGF-I and human IGF-II, a transformant producing the antibody or the antibody fragment thereof, a process for producing the antibody or the antibody fragment thereof, and a medicament comprising the antibody or the antibody fragment thereof as the active ingredient therein.Type: ApplicationFiled: September 24, 2004Publication date: October 26, 2006Applicant: KYOWA HAKKO KOGYO CO., LTD.Inventors: Kenya Shitara, Kazuyasu Nakamura, Yuji Ohki
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Publication number: 20060165695Abstract: For the effective treatment of diseases such as cancer in which hIGF participates, there have been desired to be developed antibodies which strongly bind to both factors hIGF-I and hIGF-II and inhibit their functions and fragments of these antibodies. The present invention provides antibodies which have the ability to specifically bind to human IGF-I and IGF-II to thereby inhibit the functions of human IGF-I and IGF-II and have binding activity with a binding constant of 5×109 M?1 or more measured with a biosensor BIACORE. In addition, the present invention provides diagnostics, preventives and remedies for an hIGF-mediated disease and a disease showing pathological progressing due to abnormally promoted hIGF production, which use said antibodies.Type: ApplicationFiled: April 30, 2003Publication date: July 27, 2006Inventors: Kenya Shitara, Kazuyasu Nakamura, Akiko Furuya, Rinpei Niwa, Yuji Ohki
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Publication number: 20050040298Abstract: A camera stand comprising a foot that will be placed a surface, a support having opposite ends at one of which the support is supported rotatably on the foot and turnable between a lying position and an upstanding position, an arm mechanism capable of attaching a digital camera removably at one end thereto and supported rotatably at the other end to the other end of the support such that in use the arm mechanism is adjusted in angle to the support so as to allow the camera to pick up an image of a picture/document placed under the camera while in non-use the arm mechanism is received within the confine of the support, which is then folded on the foot.Type: ApplicationFiled: August 19, 2004Publication date: February 24, 2005Applicant: Casio Computer Co., Ltd.Inventors: Yuji Ohki, Atsushi Shigemura, Masakazu Iwamoto, Shuji Shibuki
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Publication number: 20010011025Abstract: The present invention provides a radio receiver in which a first device worn on a user's wrist receives a radio voice signal, converts the received radio voice signal to an infrared signal, and transmits the infrared signal to a second device worn on a user's finger. The second device converts the received infrared signal to a voice signal, which is then output audibly as a corresponding sound. A microphone provided on a wristband receives voice and converts the same to a radio voice signal, which is then transmitted. Since the receiver has such arrangement, the receiver itself is reduced greatly in size and weight. The receiver is capable of receiving signals and making telephonic communication with others in a very natural style, which does not give an impression of strangeness to those around the receiver.Type: ApplicationFiled: January 5, 2001Publication date: August 2, 2001Inventors: Yuji Ohki, Atsushi Shigemura, Eiji Nakazawa
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Patent number: D505968Type: GrantFiled: December 23, 2003Date of Patent: June 7, 2005Assignee: Casio Keisanki Kabushiki KaishaInventors: Masakazu Iwamoto, Yuji Ohki, Atsushi Shigemura, Shuji Shibuki
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Patent number: D476240Type: GrantFiled: November 26, 2002Date of Patent: June 24, 2003Assignee: Casio Keisanki Kabushiki KaishaInventors: Naoki Kuramochi, Yuji Ohki
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Patent number: D554679Type: GrantFiled: May 24, 2006Date of Patent: November 6, 2007Assignee: Casio Keisanki Kabushiki KaishaInventors: Yosuke Nagayama, Yuji Ohki
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Patent number: D561219Type: GrantFiled: January 23, 2007Date of Patent: February 5, 2008Assignee: Casio Keisanki Kabushiki KaishaInventors: Yosuke Nagayama, Yuji Ohki
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Patent number: D497929Type: GrantFiled: July 21, 2003Date of Patent: November 2, 2004Assignee: Casio Keisanki Kabushiki KaishaInventors: Yuji Ohki, Atsushi Shigemura, Masakazu Iwamoto, Shuji Shibuki
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Patent number: D498491Type: GrantFiled: July 31, 2003Date of Patent: November 16, 2004Assignee: Casio Keisanki Kabushiki KaishaInventors: Yuji Ohki, Atsushi Shigemura, Masakazu Iwamoto, Shuji Shibuki
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Patent number: D388456Type: GrantFiled: June 24, 1996Date of Patent: December 30, 1997Assignee: Casio Computer Co., Ltd.Inventors: Kenji Takahata, Yuji Ohki
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Patent number: D404413Type: GrantFiled: February 23, 1998Date of Patent: January 19, 1999Assignee: Casio Keisanki Kabushiki KaishaInventors: Yukihiko Ida, Yuji Ohki