Abstract: A device includes: an ultrasonic wave irradiation unit that irradiates a living body with an ultrasonic wave; an ultrasonic wave detection unit that receives an ultrasonic wave reflected by the living body; and a calculation unit that calculates an amount of temperature change in the living body. The calculation unit is configured to: calculate a frequency of an ultrasonic wave amplified in the living body, based on information on a structure of the living body; perform frequency analysis on the ultrasonic wave received by the ultrasonic wave detection unit and acquire an amplitude spectrum of the ultrasonic wave; identify, from the amplitude spectrum, a peak frequency closest to the frequency of the ultrasonic wave; calculate an amount of frequency change, from two peak frequencies identified by ultrasonic wave irradiations in twice; and calculate an amount of temperature change in the living body from the amount of frequency change.

Abstract: A heat flux sensor including two temperature sensors is used to obtain time-series data of a core temperature of a living body, and a blood flow rate in a vicinity of the heat flux sensor is measured by a blood flow sensor. In an arithmetic circuit, a delay time until a fluctuation of the core temperature of the living body is reflected on an epidermis temperature is calculated on the basis of the blood flow rate measured by the blood flow sensor and a previously prepared relation between the blood flow rate and the delay time until the fluctuation of the core temperature of the living body is reflected on the epidermis temperature, and a time corresponding to the core temperature of the living body on the basis of the delay time is corrected.

Abstract: The present invention provides a pharmaceutical composition for cancer treatment comprising an antibody against CCR8.

Abstract: A light irradiation unit configured to irradiate a measurement part with a light beam that has a wavelength absorbed by glucose and a detection unit configured to detect a photoacoustic signal generated from the measurement part irradiated with the light beam emitted from the light irradiation unit are included. The light irradiation unit irradiates the measurement part by scanning the light beam 2-dimensionally. The measurement part is irradiated with the light beam through raster scanning. For example, the light beam has a beam diameter of about 100 ?m and is scanned at a scanning speed of about 100 ?m/10 ms.

Abstract: An in-vivo temperature measurement device includes a plurality of thermal resistors, temperature sensors for measuring an epidermis temperature of a living body, and temperature sensors for measuring an upper surface temperature that are provided at both ends of the thermal resistors, respectively, a memory that stores an estimation model of the core temperature of the living body that takes into consideration a non-thermal equilibrium state of the living body, and thermal resistance values of the thermal resistors, and an arithmetic circuit that estimates, based on the plurality of temperatures measured by the temperature sensors and the temperature sensors, the core temperature of the living body using the estimation model and the thermal resistance values, and the thermal resistance values are different from one another.

Abstract: An awakening induction system includes a core temperature measuring unit that measures a core temperature of a user; an awakening time estimation unit that estimates an awakening time of the user on the day before a scheduled date of awakening induction; a recommended wake-up time presentation unit that determines a recommended wake-up time range of the scheduled date based on the awakening time to present the wake-up time range to the user; a wake-up time setting unit that sets a scheduled wake-up time of the scheduled date according to an instruction from the user; and a control unit that instructs the environmental control device to raise an environment temperature around the user when it is a predetermined time before the scheduled wake-up time of the scheduled date, and also instructs the environmental control device to irradiate the user with light when the scheduled wake-up time of the scheduled date is reached.

Abstract: A measurement device includes: a first member in which a thermal resistor having a temperature sensor for measuring a heat flux transported from a measurement target is installed; a second member that is disposed in a housing including a bottom frame and a side frame of the first member and suppresses an influence of disturbance of outside air on the temperature sensor due to outside air flow or a change in temperature; and a third member that seals an upper surface portion of the first member. The measurement device has an internal structure that suppresses the influence of the disturbance of the outside air on the thermal resistor, and can accurately estimate the core temperature of the measurement target.

Abstract: An exercise assistance system includes an arithmetic circuit, a core temperature sensor that measures a core temperature of a subject, a heart rate sensor that measures a heart rate of the subject, and a display device. The arithmetic circuit is configured to cause the display device to present actions to be taken by the subject, based on the core temperature of the subject measured by the core temperature sensor and the heart rate of the subject measured by the heart rate sensor.

Abstract: A measuring device includes a first cover member having a measuring instrument, a second cover member configured to form an air layer between the second cover member and the first cover member, and a third cover member which transports heat flux from an object to be measured outside the first cover member to an upper part of the second cover member and a member having thermal conductivity and having a shape in which the member surrounds a side surface of the first member which are provided between the first cover member and the second cover member.

Abstract: A measurement device includes: a first cover member having a measuring instrument; a second cover member forming an air layer between the first cover member and the second cover member; and a third cover member that transports heat flux from a measurement target outside the first cover member to an upper portion of the second cover member between the first cover member and the second cover member.

Abstract: An installation state determination method of the present disclosure includes measuring a temperature and a heat flux of a surface of a living body using a sensor installed at a predetermined site of the living body, calculating a thermal resistance value of the living body based on the measured temperature and heat flux of the surface of the living body, comparing the calculated thermal resistance value of the living body with a reference thermal resistance value of the predetermined site of the living body, and determining an installation state of the sensor at the predetermined site of the living body based on a result of the comparison.

Abstract: An embodiment is a temperature measuring device including a sensor that measures the temperature of a skin surface of a living body and a heat flux on the skin surface, a time constant calculation unit that calculates a time constant of changes in the temperature over time on the basis of the measurement result of the temperature, a thermal resistance derivation unit that derives the thermal resistance of the living body on the basis of the time constant, and a temperature calculation unit that calculates the internal temperature of the living body on the basis of the temperature of the skin surface and the heat flux on the skin surface measured by the sensor and the thermal resistance derived by the thermal resistance derivation unit.

Abstract: An embodiment a temperature measuring device including a blood flow meter configured to measure a first blood flow near a skin surface of a subject, a sensor configured to measure a first temperature and a first heat flux of the skin surface of the subject, a storage device configured to store a second blood flow of the subject, the second blood flow being measured before the first blood flow, a thermal resistance deriver configured to derive a first thermal resistance of the subject based on an amount of change between the first and second blood flows, and a temperature calculator configured to calculate an internal temperature of the subject based on the first temperature, the first heat flux, and the first thermal resistance.

Abstract: A measurement device includes: a sensor having a temperature sensor and a heat flux sensor; a first thermal rectification member that is disposed on a side of the sensor opposite from a side of the sensor configured to be in contact with a surface of a skin of a living body which is a measurement surface of a measurement target, and that is composed of a material having a higher thermal conductivity than air; and a structural member that is placed to be in contact with the measurement surface and that is spaced from the sensor and encloses the sensor.

Abstract: A measurement device includes: a sensor including a temperature sensor configured to measure a temperature of a surface of a skin of a living body which is a measurement surface; a first cover having a hollow structure and covering the sensor; and a second cover having a hollow structure and covering the first cover to form an air layer between the first cover and the second cover.

Abstract: A light source that emits beam light, a beam shaping unit that shapes the beam light, and a pulse control unit that forms the beam light into pulse light are included. The light source emits beam light that has a wavelength that is to be absorbed by a measurement-target substance. The pulse control unit forms beam light that is emitted from the light source and with which a measurement-target part is irradiated, into pulse light that has a preset frequency and has a pulse width that is a reciprocal of twice the frequency. The beam shaping unit shapes the beam light so that a beam radius of the beam light that is emitted from the light source and with which the measurement-target part is to be irradiated is equal to a value obtained by dividing a speed of sound by ?×f, where f denotes the frequency.

Abstract: An optical circuit inspection probe includes a piezoelectric element and a gel-like medium layer provided at an end of the piezoelectric element to absorb light and convert the light into a sound wave. The piezoelectric element may be formed of piezoelectric ceramics such as Pb (Zr·Ti)O3 (PZT). The piezoelectric element has, for example, a cylindrical shape. The medium layer is formed of a hydrogel. The hydrogel may include, for example, polydimethylsiloxane (PDMS). Further, the medium layer may contain carbon.

Abstract: A photoacoustic probe includes a light source that emits light, an acoustic sensor that is arranged such that an axial direction is in parallel to a depth direction of an object to be measured and detects a sound produced from the object to be measured, a propagation member that propagates the light from the light source to the object to be measured, and propagates the sound produced from the object to be measured by emission of the light from the light source to the acoustic sensor, a reflection member that is provided within the propagation member, reflects the light from the light source, and emits reflected light to the object to be measured in the axial direction of the acoustic sensor, and a sweep mechanism capable of changing a position at which the light from the light source enters the reflection member.

Abstract: A component concentration measurement device includes a light irradiation unit that performs intensity modulation where two lights of wavelengths different from each other are intensity-modulated by signals of a same frequency and a same phase, and a measurement object is irradiated, a detecting unit that detects a photoacoustic wave generated within the measurement object due to irradiation by the light irradiation unit, and converts the detected photoacoustic wave into a first electric signal, and a processing unit that obtains a concentration of a target component contained in the measurement object, on the basis of an amplitude and a phase of the first electric signal. Light absorption coefficients of the two lights, corresponding to a background component contained in the measurement object, are equal in change amount with regard to change in temperature, and have signs different from each other.

Abstract: An embodiment is a temperature measurement method. The physical quantities related to a temperature of a living body are measured. A deep part body temperature of the living body is estimated using a coefficient and the measured physical quantities. An index is calculated using the measured physical quantities and the estimated deep part temperature. In a case in which the value of the index exceeds a threshold value, the coefficient is calibrated. It is thus possible to estimate the deep part body temperature more accurately regardless of a change in convection state of ambient air.