Abstract: Disclosed is a stable aqueous pharmaceutical composition or lyophilized pharmaceutical composition comprising a protein as the active ingredient. The pharmaceutical composition comprises a protein having physiological activity and two different nonionic surfactants, including polysorbate 80 and polyoxyethylene(160) polyoxypropylene(30) glycol as the nonionic surfactants, for example, and as optional components, sodium chloride as a neutral salt, sucrose as a disaccharide and citrate buffer as a buffering agent.

Abstract: A physical property map image generation apparatus performs: acquiring, for each pattern of a material, physical property information indicating a physical property quantity for each physical property of a product; and generating a self-organizing map and a physical property map image. A position in a map space and a physical property vector indicating a value related to a physical property quantity for each type of physical properties of the product are assigned to each node on the self-organizing map. On the physical property map image 40, each of the nodes arranged in the map space is represented by a color assigned to that node. For each node, each of two or three base color components of a color assigned to the node is determined based on a value that a physical property vector assigned to that node indicates for a physical property corresponding to that base color.

Abstract: A singular material detection apparatus (2000) acquires, for each of a plurality of materials (60), material specification information (10) representing material specifications of the material (60) and physical property information (20) indicating physical properties of a product (70) that can be generated by using the material (60). The singular material detection apparatus (2000) generates a self-organizing map (30) by using the physical property information (20). The singular material detection apparatus (2000) assigns each of pieces of material specification information (10) to one of nodes based on the physical property information (20) corresponding to that piece of the material specification information (10). Then, the singular material detection apparatus (2000) detects, from among the nodes to which the pieces of material specification information (10) are assigned, a singular node located at a singular position in a map space.

Abstract: A map image generation apparatus acquires material specification information representing a material specification of a material and physical property information representing a physical property of a product. The map image generation apparatus generates a self-organizing map by using the physical property information. A position in a map space, and a physical property vector indicating, for each of a plurality of types of physical properties of the product, a value related to a physical property quantity of the physical property are assigned to each of nodes on the self-organizing map. The map image generation apparatus assigns, by using the material specification information, a specification vector indicating a value related to the material specification to each of the nodes. The map image generation apparatus generates a map image in which the nodes are clustered or colored based on the specification vectors.

Abstract: Aqueous pharmaceutical compositions containing a fusion protein of an antibody and a lysosomal enzyme as an active ingredient, which are stable enough to be marketed, are disclosed. The aqueous pharmaceutical composition, for example, comprises the fusion protein of the antibody and the lysosomal enzyme at a concentration of 0.5 to 20 mg/mL, sodium chloride at a concentration of 0.3 to 1.2 mg/mL, sucrose at a concentration of 50 to 100 mg/mL, a nonionic surfactant at a concentration of 0.15 to 3 mg/mL, a buffer at a concentration of 3 to 30 mM, and is adjusted to pH 5.0 to 7.5.

Abstract: Novel systems and methods are provided that rapidly separate particles from a liquid. In an embodiment, a small volume of liquid (such as a blood sample, or any other solution with a concentration of particles) is input into a flow device implemented as a unilateral channel. When activated by an acoustic energy source (such as an ultrasound pulse), gas-liquid interfaces naturally occurring between the liquid in the flow device and a plurality of gas-filled cavities that line the channel will oscillate and create stable cavitation streaming within a localized region of the surrounding liquid. These oscillations create micro-vortices that gently remove and trap particles and debris from the liquid and adjacent surfaces. Fluid and particle manipulation can thus be accomplished on a passive, disposable chip that is placed on top of an external acoustic transducer with a coupling medium.

Abstract: Novel systems and methods are provided that rapidly separate particles from a liquid. In an embodiment, a small volume of liquid (such as a blood sample, or any other solution with a concentration of particles) is input into a flow device implemented as a unilateral channel. When activated by an acoustic energy source (such as an ultrasound pulse), gas-liquid interfaces naturally occurring between the liquid in the flow device and a plurality of gas-filled cavities that line the channel will oscillate and create stable cavitation streaming within a localized region of the surrounding liquid. These oscillations create micro-vortices that gently remove and trap particles and debris from the liquid and adjacent surfaces. Fluid and particle manipulation can thus be accomplished on a passive, disposable chip that is placed on top of an external acoustic transducer with a coupling medium.