Abstract: Feed additive compositions for ruminants containing (A) at least one member selected from the group consisting of hydrogenated vegetable oil and hydrogenated animal oil each having a melting point of higher than 50° C. and lower than 90° C.; (B) not less than 0.05 wt % and not more than 6 wt % of lecithin; (C) not less than 30 wt % and less than 65 wt % of a biologically active substance; (D) not less than 0.01 wt % and less than 0.8 wt % of a natural vegetable oil; and not less than 0.1 wt % and less than 6 wt % of water exhibit high protection in the rumen and are also superior in dissolution in the lower gastrointestinal tract.

Abstract: Dispersion type feed additive compositions for ruminants, containing (A) at least one selected from hydrogenated vegetable oil and hydrogenated animal oil each having a melting point of higher than 50° C. and lower than 90° C., (B) not less than 0.01 wt % and not more than 6 wt % of a surfactant, (C) not less than 16 wt % and not more than 72 wt % of a biologically active substance (excluding L-lysine and a salt thereof), and (D) not less than 1 wt % and not more than 40 wt % of L-lysine or a salt thereof, contain a biologically active substance at a high concentration, show high protection in the rumen, and are also superior in dissolution in the intestinal tract.

Abstract: Dispersion type feed additive compositions for ruminants, containing (A) at least one selected from hydrogenated vegetable oil and hydrogenated animal oil each having a melting point of higher than 50° C. and lower than 90° C., (B) not less than 0.01 wt % and not more than 6 wt % of a surfactant, (C) not less than 16 wt % and not more than 72 wt % of a biologically active substance (excluding L-lysine and a salt thereof), and (D) not less than 1 wt % and not more than 40 wt % of L-lysine or a salt thereof, contain a biologically active substance at a high concentration, show high protection in the rumen, and are also superior in dissolution in the intestinal tract.

Abstract: Provided is a crystal of a novel pyrido[3, 4-d]pyrimidine derivative having excellent CDK 4/6 inhibitory activity. A crystal of a compound represented by formula (I). In the formula, R1 represents a hydrogen atom or a C1-3 alkyl group; R2 represents a hydrogen atom or an oxo group; L represents a single bond or a C1-3 alkylene group; and X represents CH or N.

Abstract: Feed additive compositions for ruminants containing (A) at least one member selected from the group consisting of hydrogenated vegetable oil and hydrogenated animal oil each having a melting point of higher than 50° C. and lower than 90° C.; (B) not less than 0.05 wt % and not more than 6 wt % of lecithin; (C) not less than 30 wt % and less than 65 wt % of a biologically active substance; (D) not less than 0.01 wt % and less than 0.8 wt % of a natural vegetable oil; and not less than 0.1 wt % and less than 6 wt % of water exhibit high protection in the rumen and are also superior in dissolution in the lower gastrointestinal tract.

Abstract: Provided is a crystal of a novel pyrido[3, 4-d]pyrimidine derivative having excellent CDK 4/6 inhibitory activity. A crystal of a compound represented by formula (I). In the formula, R1 represents a hydrogen atom or a C1-3 alkyl group; R2 represents a hydrogen atom or an oxo group; L represents a single bond or a C1-3 alkylene group; and X represents CH or N.

Abstract: Feed additive compositions for ruminants containing (A) at least one selected from hydrogenated vegetable oil and hydrogenated animal oil each having a melting point of higher than 50° C. and lower than 90° C., (B) lecithin, (C) a biologically active substance, (D) a natural vegetable oil, and water, wherein when a scattering profile is measured after maintaining at 40° C. for 15 min, and then measured by further maintaining at 40° C. for 30 min by a small-angle and wide-angle x-ray scattering method, a peak having the maximum peak intensity in a region where the scattering angle 2? is not more than 5° has a ratio (t/s) of 0.9-1.1 wherein s is peak intensity when maintained at 40° C. for 15 min and t is peak intensity when maintained at 40° C. for 45 min, and a peak having the maximum peak intensity in a region where the scattering angle 2? is 17°-23° has a ratio (y/x) of 0.7-0.9 wherein x is peak intensity when maintained at 40° C. for 15 min and y is peak intensity when maintained at 40° C.

Abstract: Feed additive compositions for ruminants containing (A) at least one member selected from the group consisting of hydrogenated vegetable oil and hydrogenated animal oil each having a melting point of higher than 50° C. and lower than 90° C.; (B) not less than 0.05 wt % and not more than 6 wt % of lecithin; (C) not less than 30 wt % and less than 65 wt % of a biologically active substance; (D) not less than 0.01 wt % and less than 0.8 wt % of a natural vegetable oil; and not less than 0.1 wt % and less than 6 wt % of water exhibit high protection in the rumen and are also superior in dissolution in the lower gastrointestinal tract.

Abstract: An evaluating method includes an evaluating step of evaluating a state of ketosis in postpartum dairy cows for a dairy cow using at least one value of concentration values of Ala, Arg, Asn, Asp, BCAA, Cit, Cys, Glu, Gln, Gly, His, Ile, Leu, Lys, Met, 3MeHis, Orn, Phe, Pro, Ser, Tau, Thr, Trp, Tyr, and Val and concentration values of ALB, ALT, AST, BHBA, BUN, Ca, gGTP, Glc, NEFA, T-Bil, TCHO, TG, and TP in blood of the dairy cow before parturition.

Abstract: An evaluating method includes an evaluating step of evaluating a state of ketosis in postpartum dairy cows for a dairy cow using at least one value of concentration values of Ala, Arg, Asn, Asp, BCAA, Cit, Cys, Glu, Gln, Gly, His, Ile, Leu, Lys, Met, 3MeHis, Orn, Phe, Pro, Ser, Tau, Thr, Trp, Tyr, and Val and concentration values of ALB, ALT, AST, BHBA, BUN, Ca, gGTP, Glc, NEFA, T-Bil, TCHO, TG, and TP in blood of the dairy cow before parturition.

Abstract: Dispersion type feed additive compositions for ruminants, containing (A) at least one selected from hydrogenated vegetable oil and hydrogenated animal oil each having a melting point of higher than 50° C. and lower than 90° C., (B) not less than 0.01 wt % and not more than 6 wt % of a surfactant, (C) not less than 16 wt % and not more than 72 wt % of a biologically active substance (excluding L-lysine and a salt thereof), and (D) not less than 1 wt % and not more than 40 wt % of L-lysine or a salt thereof, contain a biologically active substance at a high concentration, show high protection in the rumen, and are also superior in dissolution in the intestinal tract.

Abstract: A housing tool that houses an intersecting terminal metal fitting with an electric wire includes a first housing member and a second housing member integrated by fitting cylinder opening parts to each other in an inserting manner. The first housing member includes a first housing chamber that houses a terminal connection part of the terminal metal fitting, a terminal insertion port, and an opening of an opening part of the first housing member through which the terminal metal fitting at an electric wire connection part side is drawn out to the outside. The second housing member includes a second housing chamber that houses the electric wire connection part drawn out from the opening with the end of the electric wire, an electric wire drawing port, and an opening of an opening part of the second housing member through which the terminal metal fitting is drawn out.

Abstract: A waterproof connector includes a housing in which a plurality of terminal accommodation chambers that accommodate terminals connected to electric wires are arranged in a plurality of rows, at least one waterproof member of a plurality of waterproof members provided between the housing and one of the electric wires so as to divide the inside of the housing from the outside of the housing, and a rear holder assembled to the housing so as to prevent detachment of the at least one waterproof member from the housing. The rear holder includes two combining members with mating surfaces that are combined with each other so as to hold the electric wires, and that form an electric wire accommodation portion accommodating the electric wires when the mating surfaces are mated.

Abstract: A feed additive composition includes a protective agent, lecithin, an acidic or neutral amino acid, and water. A method of producing a feed additive composition includes preparing a molten mixture of a protective agent, lecithin, and an acidic or neutral amino acid, and immersing the molten mixture in water or an aqueous liquid to obtain a solidified mixture. Feed additives may be obtained by such method. The protective agent may include a hydrogenated vegetable oil or hydrogenated animal oil having a melting point of higher than 50° C. and lower than 90° C.

Abstract: A waterproof connector includes a housing in which a plurality of terminal accommodation chambers that accommodate terminals connected to electric wires are arranged in a plurality of rows, at least one of waterproof members provided between the housing and one of the electric wires so as to divide inside and outside of the housing, and a rear holder assembled to the housing so as to prevent detachment of the at least one of waterproof members from the housing. The rear holder includes two combining members that are combined with mating surfaces with each other so as to hold the electric wires, and that form an electric wire accommodation portion accommodating the electric wires when the mating surfaces are mated.

Abstract: A housing tool that houses an intersecting terminal metal fitting with an electric wire includes a first housing member and a second housing member integrated by fitting cylinder opening parts to each other in an inserting manner. The first housing member includes a first housing chamber that houses a terminal connection part of the terminal metal fitting, a terminal insertion port, and an opening of an opening part of the first housing member through which the terminal metal fitting at an electric wire connection part side is drawn out to the outside. The second housing member includes a second housing chamber that houses the electric wire connection part drawn out from the opening with the end of the electric wire, an electric wire drawing port, and an opening of an opening part of the second housing member through which the terminal metal fitting is drawn out.

Abstract: Feed additive compositions for ruminants containing (A) at least one member selected from the group consisting of hydrogenated vegetable oil and hydrogenated animal oil each having a melting point of higher than 50° C. and lower than 90° C.; (B) not less than 0.05 wt % and not more than 6 wt % of lecithin; (C) not less than 30 wt % and less than 65 wt % of a biologically active substance; (D) not less than 0.01 wt % and less than 0.8 wt % of a natural vegetable oil; and not less than 0.1 wt % and less than 6 wt % of water exhibit high protection in the rumen and are also superior in dissolution in the lower gastrointestinal tract.

Abstract: Feed additive compositions for ruminants containing (A) at least one selected from hydrogenated vegetable oil and hydrogenated animal oil each having a melting point of higher than 50° C. and lower than 90° C., (B) lecithin, (C) a biologically active substance, (D) a natural vegetable oil, and water, wherein when a scattering profile is measured after maintaining at 40° C. for 15 min, and then measured by further maintaining at 40° C. for 30 min by a small-angle and wide-angle x-ray scattering method, a peak having the maximum peak intensity in a region where the scattering angle 2? is not more than 5° has a ratio (t/s) of 0.9-1.1 wherein s is peak intensity when maintained at 40° C. for 15 min and t is peak intensity when maintained at 40° C. for 45 min, and a peak having the maximum peak intensity in a region where the scattering angle 2? is 17°-23° has a ratio (y/x) of 0.7-0.9 wherein x is peak intensity when maintained at 40° C. for 15 min and y is peak intensity when maintained at 40° C.

Abstract: An evaluating method includes an evaluating step of evaluating a state of ketosis in postpartum dairy cows for a dairy cow using at least one value of concentration values of Ala, Arg, Asn, Asp, BCAA, Cit, Cys, Glu, Gln, Gly, His, Ile, Leu, Lys, Met, 3MeHis, Orn, Phe, Pro, Ser, Tau, Thr, Trp, Tyr, and Val and concentration values of ALB, ALT, AST, BHBA, BUN, Ca, gGTP, Glc, NEFA, T?Bil, TCHO, TG, and TP in blood of the dairy cow before parturition.

Abstract: A shielded connector structure includes a shielded wire for connecting a device, a shielded connector, and a metal member provided on the device. The shielded connector includes a terminal fitting, a shield terminal, a housing, and a bolt for fixing the housing to the metal member. The metal member includes a circular insertion hole and a female screw portion. The circular insertion hole includes an inner circumferential projected portion and a cutout portion that divides a part of the inner circumferential projected portion. The housing includes a cylindrical housing main body and a fixing flange portion. The housing main body includes a main body insertion portion inserted into the circular insertion hole and a projection portion which protrudes from an outer circumferential surface of the main body insertion portion in conformity with a position of the inner circumferential projected portion.