Abstract: An antibody-drug conjugate represented by formula (I): (where Ab is an antibody, X is a group represented by formula (X-1), formula (X-2) or formula (X-3): (where at the left represents the binding site with NH and at the right represents the binding side with D), D is a group represented by formula (D-1) or formula (D-2): (where represents the binding site with X), and n is in the range of about 1 to about 8).

Abstract: A puncturing device comprising: a resin tube having a distal end and a proximal end, and extending in a longitudinal direction; a metal tube disposed in a lumen of the resin tube; a metal member disposed at a distal end portion of the metal tube; and a metal tip disposed at a distal end portion of the metal member, wherein a flow path is present between an inner surface of the resin tube and an outer surface of the metal member and is in communication with a lumen of the metal tube, the resin tube further includes an opening portion through which the flow path and outside of the resin tube are in communication with each other, and the opening portion is present on a distal side relative to a distal end of the metal tube and on a proximal side relative to the proximal end of the metal tip.

Abstract: A medical shaft includes a shaft including at least one lumen extending in a longitudinal direction; a core member disposed in the lumen, the core member extending along the longitudinal direction; and a tubular member disposed on an outer side of the core member in a same lumen as a lumen in which the core member is disposed, the tubular member having a length, in the longitudinal direction, which is less than a length of the core member, wherein in the lumen, an area of a cross-section of the lumen on a plane perpendicular to the longitudinal direction in a portion in which the tubular member is disposed is greater than an area of a cross section of the lumen on a plane perpendicular to the longitudinal direction in a portion in which the tubular member is not disposed.

Abstract: The present invention provides certain substituted chromane, isochromane, and dihydroisobenzofuran compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein ring A is a moiety selected from: and ring B, n, R1, R2, R2A, R3, and R3A are as defined herein. The compounds of the invention are useful as mGluR2 inhibitors, or mGluR2 negative allosteric modulators (NAMs), and may be useful in methods of treating a patient for diseases or disorders in which the mGluR2-NAM receptor is involved, such as Alzheimer's disease, cognitive impairment, mild congnitive impairment, schizophrenia and other mood disorders, pain disorders and sleep disorders, by administering to the patient a therapeutically effective amount of a compound of the invention, or a pharmaceutically acceptable salt thereof.

Abstract: The present invention provides certain substituted chromane, isochromane, and dihydroisobenzofuran compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein ring A is a moiety selected from: and ring B, n, R1, R2, R2A, R3, and R3A are as defined herein. The compounds of the invention are useful as mGuR2 inhibitors, or mGluR2 negative allosteric modulators (NAMs), and may be useful in methods of treating a patient for diseases or disorders in which the mGuR2-NAM receptor is involved, such as Alzheimer's disease, cognitive impairment, mild cognitive impairment, schizophrenia and other mood disorders, pain disorders and sleep disorders, by administering to the patient a therapeutically effective amount of a compound of the invention, or a pharmaceutically acceptable salt thereof.

Abstract: A clip device for an endoscope of the present invention comprises an outer tubular body 70; an inner tubular body 80 provided in the outer tubular body 70; a line member 50 placed in the inner tubular body 80; and a pinching part 20, for holding an indwelling clip, connected to a distal side of the line member 50; wherein the pinching part 20 has two pinching base plates 30a and 30b, a blade part 40a is provided at a distal end of the pinching base plate 30a and formed toward an inside of the pitching base plate 30a, a blade part 40b is provided at a distal end of the pinching base plate 30b and formed toward an inside of the pinching base plate 30b, a Young's modulus of the blade part 40a is smaller than that of the pinching base plate 30a, and a Young's modulus of the blade part 40b is smaller than that of the pinching base plate 30b.

Abstract: An object of the present invention is to provide a medical tubular body that is excellent in visibility under X-ray fluoroscopic control, insertion property into a catheter and sliding property in a catheter, that suppresses contact of a marker with a tubular body or an adjacent marker in a diameter reduction state, and that is able to further reduce its diameter. The present invention provides a medical tubular body 100 comprising a tubular body whose diameter is expandable and a marker 121 provided inside the tubular body.

Abstract: A clip device for an endoscope of the present invention comprises an outer tubular body 70; an inner tubular body 80 provided in the outer tubular body 70; a line member 50 placed in the inner tubular body 80; and a pinching part 20, for holding an indwelling clip, connected to a distal side of the line member 50; wherein the pinching part 20 has two pinching base plates 30a and 30b, a blade part 40a is provided at a distal end of the pinching base plate 30a and formed toward an inside of the pitching base plate 30a, a blade part 40b is provided at a distal end of the pinching base plate 30b and formed toward an inside of the pinching base plate 30b, a Young's modulus of the blade part 40a is smaller than that of the pinching base plate 30a, and a Young's modulus of the blade part 40b is smaller than that of the pinching base plate 30b.

Abstract: A micro forceps 12 according to the present invention comprises: a housing 22 having an opening part 27 on a side 23 thereof; a rotating body 32 that is retained in the housing 22, rotatable around a long axis of the housing 22, and partially exposed from the opening part 27; a clip part 52 for clipping an object; a wire rod part provided with the clip part 52 on one side, and connected to the rotating body 32 on the other side; an opening/closing operation part 62 that is retained in the housing 22, movable along the long axis direction of the housing 22, and partially exposed from the opening part 27; and a tubular part 72 connected to the opening/closing operation part 62; wherein the clip part 52 is in a closed state where the clip part 52 is placed in the tubular part 72 when the opening/closing operation part 62 is moved to a clip part 52 side; and the clip part 52 is in an opened state where the clip part 52 comes out of the tubular part 72 when the opening/closing operation part 62 is moved to opposit

Abstract: An object of the present invention is to provide a medical tubular body that is excellent in visibility under X-ray fluoroscopic control, insertion property into a catheter and sliding property in a catheter, that suppresses contact of a marker with a tubular body or an adjacent marker in a diameter reduction state, and that is able to further reduce its diameter. The present invention provides a medical tubular body 100 comprising a tubular body whose diameter is expandable and a marker 121 provided inside the tubular body.