Abstract: Various embodiments of the present invention disclose processes and systems for the off-line in-vitro purification of plasma harvested from a patient. In an embodiment of a process, in a first step cellular components are capable of being eliminated by membrane plasma separation at temperatures sufficiently high to avoid formation of a cryoaggregates, and in a second step the resulting plasma solution is cooled to a temperature that allows the formation of cryoaggragated molecules, but no formation of a cryogel.

Abstract: The present invention provides an inflow cannula tip that is shaped to prevent suction with the ventricular wall and adapted to prevent platelet adhesion. In particular, the inlet portion of the cannula tip comprises two projections extending from the cylindrical body of the cannula tip with gaps between the projections. The projections may have beveled edges. The inlet portion of the cannula tip can accept blood flow from either the gaps in the side or from the bottom of the tip. Even if the edge of the cannula tip is close to or even touching ventricle wall, a suction condition will not result, as blood is allowed to flow through the gaps between the projections.

Abstract: A control system for a continuous flow rotary blood pump is provided. A normal operating range of the blood pump is established. The normal operating range may comprise a normal pump flow range and a normal pressure head range. A target rotational speed of the pump is set in accordance with the normal operating range. A current operating condition of the blood pump is determined. The current operating condition may comprise a current pump flow, a current pressure head, and a current rotational speed of the pump. The current operating condition is compared with the normal operating range. An appropriate control algorithm is selected from a plurality of available control algorithms based on the comparison. The target rotational speed of the pump is adjusted using the selected control algorithm to maintain or recover the normal operating range.

Abstract: The present invention provides an inflow cannula tip that is shaped to prevent suction with the ventricular wall and adapted to prevent platelet adhesion. In particular, the inlet portion of the cannula tip comprises two projections extending from the cylindrical body of the cannula tip with gaps between the projections. The projections may have beveled edges. The inlet portion of the cannula tip can accept blood flow from either the gaps in the side or from the bottom of the tip. Even if the edge of the cannula tip is close to or even touching ventricle wall, a suction condition will not result, as blood is allowed to flow through the gaps between the projections.

Abstract: The present invention provides methods for detecting an abnormal condition of a blood pump system based on the power consumption of the pump actuator. By plotting differentiated power consumption of the pump actuator over time against the power consumption, a plot pattern is obtained. A change of the plot pattern area and/or a movement of the plot pattern will indicate a change in condition of the pump. A Heart Pump Area (HPA) index may be established which corresponds to the changing area of the plot pattern over time. A Heart Pump Position (HPP) index may be established which corresponds to the changing position of the plot pattern over time (e.g., corresponding to the distance the plot pattern has moved). By plotting the HPA index against the HPP index, changes in the condition of the pump can be monitored and any abnormal condition of the pump can be detected.

Abstract: It is an object of the present invention to realize a small and light blood pump that can control thrombosis and moreover, endure a prolonged use.

Abstract: A control system for a continuous flow rotary blood pump is provided. A normal operating range of the blood pump is established. The normal operating range may comprise a normal pump flow range and a normal pressure head range. A target rotational speed of the pump is set in accordance with the normal operating range. A current operating condition of the blood pump is determined. The current operating condition may comprise a current pump flow, a current pressure head, and a current rotational speed of the pump. The current operating condition is compared with the normal operating range. An appropriate control algorithm is selected from a plurality of available control algorithms based on the comparison. The target rotational speed of the pump is adjusted using the selected control algorithm to maintain or recover the normal operating range.

Abstract: The present invention provides methods for detecting an abnormal condition of a blood pump system based on the power consumption of the pump actuator. By plotting differentiated power consumption of the pump actuator over time against the power consumption, a plot pattern is obtained. A change of the plot pattern area and/or a movement of the plot pattern will indicate a change in condition of the pump. A Heart Pump Area (HPA) index may be established which corresponds to the changing area of the plot pattern over time. A Heart Pump Position (HPP) index may be established which corresponds to the changing position of the plot pattern over time (e.g., corresponding to the distance the plot pattern has moved). By plotting the HPA index against the HPP index, changes in the condition of the pump can be monitored and any abnormal condition of the pump can be detected.

Abstract: The present invention provides an inflow cannula tip that is shaped to prevent suction with the ventricular wall. In particular, the inlet portion of the cannula tip comprises two projections extending from the cylindrical body of the cannula tip with gaps between said projections. The projections may have beveled edges. The inlet portion of the cannula tip can accept blood flow from either the gaps in the side or from the bottom of the tip. Even if the edge of the cannula tip is close to or even touching ventricle wall, a suction condition will not result, as blood is allowed to flow through the gaps between the projections.

Abstract: A control system for a continuous flow rotary blood pump is provided. A normal operating range of the blood pump is established. The normal operating range may comprise a normal pump flow range and a normal pressure head range. A target rotational speed of the pump is set in accordance with the normal operating range. A current operating condition of the blood pump is determined. The current operating condition may comprise a current pump flow, a current pressure head, and a current rotational speed of the pump. The current operating condition is compared with the normal operating range. An appropriate control algorithm is selected from a plurality of available control algorithms based on the comparison. The target rotational speed of the pump is adjusted using the selected control algorithm to maintain or recover the normal operating range.

Abstract: A control system for a continuous flow rotary blood pump is provided. A normal operating range of the blood pump is established. The normal operating range may comprise a normal pump flow range and a normal pressure head range. A target rotational speed of the pump is set in accordance with the normal operating range. A current operating condition of the blood pump is determined. The current operating condition may comprise a current pump flow, a current pressure head, and a current rotational speed of the pump. The current operating condition is compared with the normal operating range. An appropriate control algorithm is selected from a plurality of available control algorithms based on the comparison. The target rotational speed of the pump is adjusted using the selected control algorithm to maintain or recover the normal operating range.

Abstract: It is an object of the present invention to realize a small and light blood pump that can control thrombosis and moreover, endure a prolonged use.

Abstract: The present invention provides a blood pump capable of substantially completely preventing thrombus from attaching to the inner bottom portion of the casing without lowering the anti-hemolytic characteristic of blood. A centrifugal blood pump in accordance with the present invention comprises a pump casing, a suction inlet disposed at the central portion on the upper side of the casing, a delivery outlet disposed at the bottom peripheral portion of the casing, a main impeller (D in diameter) for forming a centrifugal flow of blood supplied from the suction inlet in the range from the central portion to the peripheral portion to feed the blood to the delivery outlet, wherein the main impeller is provided with an stirring impeller, the surface of which is provided with one or more stirring elements (L in entire length) having the shape of a fin or a groove, and the dimensions of the stirring elements are determined to satisfy inequality (1): 0.43<LD<1.30 and inequality (2) 0.03<S/A<0.

Abstract: A centrifugal blood pump used for heart-lung machines or the like comprising an impeller provided with pump vanes and a magnet means such as permanent magnets, a casing having an inlet port and an outlet port and rotatably accommodating the impeller, and a magnet drive means disposed outside the casing, wherein the impeller is supported by at least three balls above the bottom plate of the casing, held at the center of the bottom plate and rotated around the center axis of the impeller by the magnet means and the magnet drive means. When the upper and lower ends of the rotation shaft of the impeller are supported by the casing, the upper end of the rotation shaft is supported by a bearing embeddedly disposed at the top section of the conical section of the casing, and the inlet port of the casing is disposed adjacent to and eccentric from the top section.

Abstract: A centrifugal blood pump, used for heart-lung machines or the like, having at least one impeller, a casing having an inlet and an outlet, the casing formed to have a space for rotatably housing the at least one impeller and a magnetic drive disposed outside the casing. The impeller may have vanes attached thereto for forcing fluid through the casing. Further the vanes may have magnets imbedded therein. The magnetic drive and the imbedded magnets cooperate to rotate the impeller. The impeller may have pivots integrated at opposing ends for allowing the impeller to rotate about a horizontal axis. The pivots may be supported by pivot bearings disposed within the casing. The pivots and the pivot bearings may be made of a ceramic material.

Abstract: A blood pump used for heart-lung machines comprising an impeller, a casing having a suction inlet and a delivery outlet and rotatably encasing the impeller, a magnetic driver disposed outside the casing, and a magnetic attraction force adjuster. The impeller has a rotationally symmetric shape, such as a conical shape, is equipped with vanes having a pumping function on the side surface thereof and is also equipped with magnets, such as permanent magnets. The magnetic driver for rotating the impeller in cooperation with the magnets comprises a magnet assembly magnetically connected to the magnets and a rotation driver for rotating the magnet assembly. The magnetic attraction force adjuster adjusts the magnetic attraction force generated between the magnets and the magnet assembly by adjusting the gap between the magnets and the magnet assembly or by adjusting the exciting current of electromagnets when electromagnets are used for the magnet assembly.

Abstract: A centrifugal blood pump for heart-lung machines or the like. An impeller is provided with pump vanes and a magnet. The impeller is rotatably accommodated in a casing having an inlet and an outlet. A magnet drive means is disposed outside the casing. The impeller is supported by at least three balls above a bottom plate of the casing, held at the center of the bottom plate and rotated around the center axis of the impeller by the magnet means and the magnet drive means. When the upper and lower ends of the rotation shaft of the impeller are supported by the casing, the upper end of the rotation shaft is supported by a bearing embeddedly disposed at the top section of the conical section of the casing, and the inlet of the casing is disposed adjacent to and eccentric from the top section.

Abstract: A blood pump used for heart-lung machines comprising an impeller, a casing having a suction inlet and a delivery outlet and rotatably encasing the impeller, a magnetic driver disposed outside the casing, and a magnetic attraction force adjuster. The impeller has a rotationally symmetric shape, such as a conical shape, is equipped with vanes having a pumping function on the side surface thereof and is also equipped with magnets, such as permanent magnets. The magnetic driver for rotating the impeller in cooperation with the magnets comprises a magnet assembly magnetically connected to the magnets and a rotation driver for rotating the magnet assembly. The magnetic attraction force adjuster adjusts the magnetic attraction force generated between the magnets and the magnet assembly by adjusting the gap between the magnets and the magnet assembly or by adjusting the exciting current of electromagnets when electromagnets are used for the magnet assembly.

Abstract: A novel cardiac assist blood pump is disclosed. The blood pump comprises a pump chamber, a pressurizing chamber provided adjacent to the pump chamber, a rotor chamber provided adjacent to the pressurizing chamber and an impelled positioned in the pump chamber, said pump being characterized in that the rotation shaft of the impeller means is provided with a first seal member having a skirt portion which is made of an elastomeric material and extends downward to cover the clearance between the rotation shaft and the first rotation shaft hole provided between the pump chamber and the pressurizing chamber and a second seal member similar to the first one which covers the clearance between the rotation shaft and the second rotation shaft hole provided between the pressurizing chamber and the rotor chamber; and tile pressurizing liquid is forced into the pressurizing chamber.

Abstract: A centrifugal blood pump, used for heart-lung machines or the like, comprises an impeller, a casing having a suction inlet and a delivery outlet and being equipped with a space for rotatably accommodating the impeller, and a magnetic drive means disposed outside the casing. The impeller is of a rotationally symmetric shape and has a rotary vane section and a cylindrical section equipped with a magnet means. The magnet drive means for generating a rotating magnetic field coaxially encloses the magnet means of the above-mentioned cylindrical section and rotates the impeller in cooperation with the magnet means. At least the end section of the impeller's rotation center on the rotary vane section side is supported preferably by a pivot bearing. The pivot and the bearing thereof are preferably made of ceramics.