Patents by Inventor Yukihiro Kuge

Yukihiro Kuge has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for producing tetrahydroisoquinoline-3-carboxylic acid compounds
    Patent number: 5602255
    Abstract: The present invention relates to a process for producing 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid compounds or salts thereof represented by the following formula (II): ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 independently represent hydrogen, hydroxy or lower alkoxy, and R.sup.4 represent hydrogen, lower alkyl, aryl or aralkyl, the process comprising, allowing phenylalanine compounds to react with formaldehyde or paraformaldehyde in the presence of sulfuric acid or hydrobromic acid, the phenylalanine compounds being represented by the following formula (I): ##STR2## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the same meaning as defined above.
    Type: Grant
    Filed: April 4, 1995
    Date of Patent: February 11, 1997
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Yukihiro Kuge, Toru Sugaya, Shinji Tomioka
  • Process for producing L(-)-tetrahydrofolic acid
    Patent number: 4929551
    Abstract: The invention relates to a process for producing L(-)-tetrahydrofolic acid which comprises allowing dihydrofolate reductase to act upon dihydrofolic acid in the presence of (1) NADP or NADPH, and (2) glucose and glucose dehydrogenase. L(-)-tetrahydrofolic acid is useful as the intermediate for L(-)-leucovarin.
    Type: Grant
    Filed: August 15, 1989
    Date of Patent: May 29, 1990
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Tamotsu Eguchi, Takashi Oshiro, Yukihiro Kuge, Kenichi Mochida, Takayuki Uwajima