Patents by Inventor Yukimasa Nozaki

Yukimasa Nozaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Octahydro-2-naphthalenecarboxylic acid derivative, its production and use
    Patent number: 5498627
    Abstract: This invention provides a novel compound TAN-1813 having farnesyltransferase-inhibitory, cell growth-inhibitory, and anti-tumor activities; its production; farnesyltransferase-inhibiting agent; anti-tumor agent; pharmaceutical composition comprising a compound TAN-1813; and a novel microorganism capable of producing said compound.
    Type: Grant
    Filed: April 14, 1995
    Date of Patent: March 12, 1996
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Takafumi Ishii, Tsuneaki Hida, Yukimasa Nozaki, Koichiro Ootsu
  • TAN-1120, its derivatives, production and use thereof
    Patent number: 5147860
    Abstract: The present invention relates to a compound of the formula: ##STR1## wherein X is hydroxyl group or hydrogenatom, or a salt thereof. The compound (I) has an acitivity to inhibit angiogenesis, which is useful for prophylaxis and therapy of various diseases accompanying abnormally increased angiogenesis, especially of tumors.
    Type: Grant
    Filed: December 7, 1989
    Date of Patent: September 15, 1992
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Tsuneo Kanamaru, Yukimasa Nozaki, Masayuki Muroi
  • Angiostatic agents
    Patent number: 5135920
    Abstract: Dextran sulfate, .beta.-1,3-glucan sulfate, and the salts thereof are angiostatic and useful for treatment and prevention of various diseases caused by abnormally accelerated angiogenesis. Combination of such a compound with a steroidal or non-steroidal substance increases the angiostatic activity of each compound to induce the combined effect.
    Type: Grant
    Filed: November 9, 1989
    Date of Patent: August 4, 1992
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Tsuneo Kanamaru, Yukimasa Nozaki, Katsuichi Sudo
  • Cephem compounds and their production
    Patent number: 4667027
    Abstract: A compound of the formula: ##STR1## wherein R.sup.1 stands for hydrogen or formylamino, R.sup.2 is a residue of amino acid selected from the group consisting of serine and alanine, or a peptide of at least one of these amino acids, or hydrogen, R.sup.3 stands for --NH--C(.dbd.NH)--NH.sub.2 or --CH.sub.2 NH.sub.2, or its salt, which can be produced by cultivating a microorganism belonging to the genus Xanthomonas, is useful as a therapeutic agent against infectious disease caused by bacteria.
    Type: Grant
    Filed: December 14, 1984
    Date of Patent: May 19, 1987
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Setsuo Harada, Yukimasa Nozaki, Hideo Ono
  • Antibiotics, their production and use
    Patent number: 4656288
    Abstract: Antibiotic TAN-558 produced by a microorganism of the genus Empedobacter or genus Lysobacter, its p-nitrobenzyl- or benzhydryl ester derivative, or their N-deacetylated derivatives or salts thereof possess antimicrobial activities against Gram-positive and Gram-negative bacteria, and can be used as a therapeutic agent for bacterial infections in mammals, fowls, etc.
    Type: Grant
    Filed: March 20, 1985
    Date of Patent: April 7, 1987
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Hideo Ono, Yukimasa Nozaki, Setsuo Harada
  • Cephalosporins and their production
    Patent number: 4587333
    Abstract: A compound of the formula: ##STR1## wherein R.sup.1 stands for hydrogen or formylamino, R.sup.2 stands for hydrogen, alanyl or alanyl-alanyl, or its salt, which can be produced by cultivating a microorganism belonging to the genus Lysobacter, is useful as a therapeutic agent against infectious disease caused by bacteria.
    Type: Grant
    Filed: September 14, 1984
    Date of Patent: May 6, 1986
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Hideo Ono, Yukimasa Nozaki, Setsuo Harada
  • Method for producing antibiotic T-42082 and antibiotic T-42082
    Patent number: 4069316
    Abstract: This invention provides a method for producing Antibiotic T-42082 wherein the method comprises cultivating an Antibiotic T-42082-producing strain of the genus Streptomyces (ATCC 31080) to permit said strain to elaborate and accumulate Antibiotic T-42082 in the resultant broth and harvesting the antibiotic from said broth. This invention also includes the novel antibiotic.
    Type: Grant
    Filed: November 1, 1976
    Date of Patent: January 17, 1978
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Akira Imada, Yukimasa Nozaki, Toru Hasegawa, Masahiko Yoneda