Patents by Inventor Yukitaka Takatsu

Yukitaka Takatsu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for stabilizing peptides and freeze-dried medicinal compositions containing peptides obtained by using the method
    Patent number: 6274553
    Abstract: A method is provided for elevating the stability of peptides containing the sequence -Asp-Gly- or -Asn-Gly- by preventing these sequences from changing into succinimide compounds or &bgr;-transition compounds. The method comprises adding an organic acid to a solution of peptides containing these sequences to bring the pH value of the solution to a pH of between 5 and 6.5 followed by freeze-drying. In one embodiment, sucrose or mannitol is added together with the organic acid. Freeze-dried medicinal compositions obtained by using the method have excellent stability. In one embodiment of the invention, compositions produced by the method are provided and comprise hirudin or hirudin variants.
    Type: Grant
    Filed: December 21, 1999
    Date of Patent: August 14, 2001
    Assignee: Japan Energy Corporation
    Inventors: Hideyuki Furuya, Hiroyuki Morita, Yukitaka Takatsu, Kose Michibuchi, Makoto Tanigawa