Publication number: 20200323846
Abstract: This disclosure provides compounds of Formula I, II, and III and pharmaceutically acceptable salts thereof for use as mitochondrial uncouplers, where the variables, e.g. R1-R9, X1, X2, and Y1 are defined in the specification. The disclosure also provides pharmaceutical compositions comprising a compound or pharmaceutically acceptable salt of Formula I, II, or III, alone or in combination with another active compound. Compounds and compositions of Formula I, II, and III are useful for treating or preventing certain conditions such as obesity, type II diabetes, fatty liver disease, insulin resistance, Parkinson's disease, ischemia reperfusion injury, heart failure, non-alcoholic fatty liver disease (NALFD), and non-alcoholic steatohepatitis (NASH). Compounds of Formula I, II, and III are also useful for regulating glucose homeostatis and insulin action.
Type:
Application
Filed:
May 22, 2018
Publication date:
October 15, 2020
Applicants:
University of Virgina Patent Foundation, Virginia Tech Intellectual Properties, Inc., NewSouth Innovations Pty Limited
Inventors:
Kyle HOEHN, Webster L. SANTOS, Elizabeth S. CHILDRESS, Yumin DAI, Jacob MURRAY, Jose SANTIAGO-RIVERA